PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Correcting agents, dyes

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Corrective substances are added to the composition of tablets in order to improve their taste, color and smell. Corrective substances are of great importance in pediatric medical practice. It has been established that an effective therapeutic agent with an unpleasant taste in children has many times less effect or does not have a therapeutic effect at all. It is necessary to take into account the possibility of changing the absorption of LV from corrected dosage forms. It is known, for example, that sugar syrup and some fruit syrups reduce the resorption of amidopyrine, antibiotics from the dosage forms corrected by them.with

Classification of patches by composition

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According to the composition of the adhesive masses, plasters are divided into ordinary and rubber. Ordinary plasters (Emplastra Ordinarid) are divided into lead, lead-resin, lead-wax and resin-wax depending on the substances prevailing in the plaster base. These patches contain lead soap as a mandatory component, which has the following positive properties: it has no hardness, is easily fused with resins, waxes and various medicinal substances, and is also stable during storage. A negative property of lead soaps is their non-indifference. A simple lead plaster (Emplastrum Plumbi simplex). The group of lead patches includes a simple lead patch, which is chemically a mixture of lead salts of higher fatty acids (stearic, palmitic and oleic), and also contains traces of unsaponified fats and no more than 3%…

Granulation and spray drying

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6490264

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This type of granulation is advisable to use in cases of undesirable prolonged contact of the granulated product with air, if possible directly from the solution (for example, in the production of antibiotics, enzymes, products from raw materials of animal and vegetable origin). This is due to the short drying time (from 3 to 30 seconds), the low temperature of the material (40-60 ° C) and the high temperature of the carrier, which is provided by high relative speeds and high values of the driving force of the drying process. There are two ways to carry out this process: spraying suspensions of fillers with the addition of a bonding agent and baking powder. The amount of solid phase in the suspension can be 50-60%.

Diphilic bases

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6489666

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Diphilic bases have a soft consistency and are easily distributed over the surface of the skin and mucous membranes. Diphilic bases are divided into two groups - absorption and emulsion. Absorption bases are hydrophobic. These are anhydrous compositions of hydrophobic bases with an emulsifier (surfactant), which have the ability to incorporate the aqueous phase to form an emulsion system of the water—oil type. Their composition most often includes mixtures of petroleum jelly, petroleum jelly oil, ceresine and other hydrocarbons with emulsifiers. Surfactants, which are part of the absorption bases, usually contribute to enhancing the therapeutic activity of ointments. Absorption Diphilic bases can be divided into two groups: Diphilic bases consisting of hydrocarbons and emulsifiers (surfactants) of the water—oil type (vaseline and lanolin or wool wax...

Encapsulation by fluidized bed coating method

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Application of coatings in a fluidized bed of fine particles under supercritical conditions is a new developing technology designed for encapsulation of thermolabile products. Supercritical liquids are unique solvents because their density is similar to the densities of liquids, while the viscosity and diffusion coefficient are close to these indicators for gases. Spraying of supercritical solutions makes it possible to obtain droplets and particles of submicron size, as well as to spray on other particles. Since the cohesive and adhesive forces for supercritical solutions are small compared to these indicators for organic solvents, the capillary compression force is insignificant.

Making rubber patches

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Rubber patches (Collemplastra) are made on the basis of synthetic and natural non-vulcanized rubber. With the addition of resins, balms, fat-like and other substances, such as antioxidants. the advantages of rubber as a plaster base include the absence of an irritating effect on the skin, indifference to many medicinal substances, elasticity, air and moisture resistance. There are also disadvantages — it is weak plasticity and stickiness. Usually, rosin is added to it to eliminate them and make the rubber patch more sticky.

Dredge coating for tablets

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The term “coated coating” comes from the French word “dragee” and means “applying a sugar coating”. A drained tablet consists of a core tablet containing a medicinal substance (substance) and a coating containing several excipients. The core tablet must be mechanically strong. Tablets to be drained should not have a flat shape to avoid sticking together. Let’s consider one of the old methods of coating — sugar coating. Sugar coating is an effective way of applying large layers of coatings, primarily to mask the taste. This type of coating is used for temperature-sensitive and brittle solid dosage forms. The first stage of this technology is the spraying of a solution for spraying onto a particle (tablet, pellet). The air supplied to the device evaporates the…

Granulation and fluidized bed drying

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6490170

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Granulation in a fluidized bed (PS) allows you to combine mixing, granulation, drying and dusting operations in one machine. Therefore, the granulation method in PS is increasingly used in the modern pharmaceutical industry. The process consists in mixing powdered ingredients in a suspended layer, followed by their moistening with a granulating liquid with continued stirring. A fluidized bed is formed when upward-directed air lifts a layer of solid particles, which begins to "boil" like a liquid. The layer is in a fluidized state. The forces acting on the particles in the state of fluidization are in equilibrium. The particles in the fluidized bed are mixed so efficiently that the temperature over the entire height of the fluidized bed remains constant. The general design of the...

Mustard patches are a type of rubber patch

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They are rectangular sheets of paper measuring 8x12.5 cm, covered on one side with rubber glue and a layer of powder of low—fat mustard seeds 0.3-0.5 mm thick. The powder is obtained from the seeds of black (Semina Sinapis nigra) and Sarepta mustard (Semina Sinapis junceae), which contain the glycoside sinigrin, cleaved under the influence of the enzyme myrosine on glucose, potassium hydrosulfate and essential mustard oil (allylisothiocyanate). This is the most essential mustard oil and causes severe irritation and redness of the skin. Mustard seeds contain up to 35% of fatty oil, the presence of which has a bad effect on the quality of mustard plasters, as it causes rancidity of the powder and worsens their therapeutic effect.

Introduction to medical capsule production technology

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Capsule (from Lat. capsula — a case or shell) is a metered dosage form consisting of a drug enclosed in a shell. In 1846, Frenchman Jules Leuby received a patent for a "method of manufacturing medicinal coatings". He was the first to start making two-piece capsules, which he received by lowering metal pins fixed on a disk into a gelatin solution. The two parts were adjusted to each other and formed a "cylindrical box in the shape of a silkworm cocoon." In these capsules, pharmacists could already put powders or mixtures thereof, made according to a doctor's prescription. In its modern form, this method is used in the production of solid bivalve gelatin capsules. Capsules in their modern form can be considered a relatively young...