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In both cases there is a fine powder in fluidized bed and a granulating liquid atomized to the required degree of dispersion. The granulating liquid is atomized using nozzles, which are a very important part of any combined granulation and fluidized bed drying equipment. Different types of nozzles are used in production. There are: single-liquid nozzles, in which only liquid is atomized and high pressure is required; two-liquid nozzles, in which liquid and air are mixed and atomized, mixing in the external environment (externally mixed nozzles) or inside the nozzle (internally mixed nozzles). Depending on the nozzle type, different atomization modes are used. Different nozzle types are used at different mix pressures and depending on the consistency of the final product.
Pharmaceutical Glossary
Technical specifications
The process in the PS apparatus consists of four stages: Mixing is the first technological operation affecting the granulate quality. The uniformity of mixing depends on the aerodynamic mode of the apparatus, the ratio of components in the mixture, the shape and density of particles. At the stage of adding granulating liquid there is clumping of particles of granulated mass due to the bonding forces of both the liquid itself and the solution formed by wetting the surface layer of the processed material with this liquid. At the drying stage, the lumps turn into solid agglomerates, partially destroyed by friction between themselves and with the walls of the apparatus. The process of granulation in fluidized bed occurs simultaneously with drying of the resulting granules with hot air. The finished granulate is dried to the optimum moisture content. Powdering of the dried granulate takes place in the same apparatus. The obtained dried granules may have a rough surface, which makes it difficult to pour them out of the feed hopper into the matrix of the tablet machine in the process of tabletting.
Additional information
In addition, the granules may stick to the die and punches of the tablet press, which can cause both weight disturbances and some defects in the tablets. To avoid these undesirable phenomena, the operation of “powdering” the granulate is resorted to. This operation is carried out by free application of finely ground substances to the surface of the granules in a periodic mode. By powdering, sliding and loosening agents are introduced into the tablet mass. Formation and growth of granules in the fluidized bed occurs due to two physical processes: wetting clumping and sticking with subsequent agglomeration. The quality of granules and their fractional composition depend on many factors determining the course of the granulation process, the main ones being the velocity of the liquefying gas, the composition and feed rate of the granulating liquid, and the temperature in the bed. There are two hypotheses about the mechanism of granule formation in fluidized bed: granulation centers in fine powder are droplets of granulating liquid; granulation centers are particles of a certain size introduced into the disperse composition of the powder.
Order status tracking
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 21/10/2024 07:48
Good afternoon, Zoe, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 21/10/2024 07:49
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled before lunch to open the box and test. 21/10/2024 07:58
Alexander, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 21/10/2024 08:02
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled closer to evening to open the box and test. 21/10/2024 08:08
David, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 21/10/2024 08:09
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 21/10/2024 08:18
Hello Hazel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Tempe . 21/10/2024 08:18
Tell me the NJ-120 automatic capsule machine went ? 21/10/2024 08:28
Alexander, good afternoon. Yes, already tomorrow by lunchtime you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 21/10/2024 08:30
HX-6 Plastic Tube Filling and Sealing Machine in Vienna? Price delivery terms and conditions 21/10/2024 08:38
David, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 21/10/2024 08:39
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 21/10/2024 08:48
Good day, Emma! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 21/10/2024 08:51
Remember me? There's a delivery in the Salzburg 21/10/2024 08:58
Brooklyn, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be between 12:00-14:00 in Salzburg . 21/10/2024 09:01
Good afternoon, I am hoping in the interval from 14:00-16:00 to get the UNIC 600A Tablet Press in Cambridge ! Please comment. 21/10/2024 09:08
Good day, Bella! Our manager has communicated with the delivery service, the equipment will be delivered to Cambridge at your address. Please let us know when you receive it. 21/10/2024 09:10
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 21/10/2024 09:18
Hello Violet, Transportation has advised that tomorrow until 14:30 driver will definitely deliver the box to your address. We apologize. 21/10/2024 09:21
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES