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СATALOGUE / EQUIPMENT WITH REVIEWS / PHARMA / OINTMENT PRODUCTION / Archive by Category "HEPARIN OINTMENT"

HEPARIN OINTMENT

Standardization of ointments in production

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  • Standardization of ointments in production
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Intra-shop control of ointments is carried out at almost every stage of production and especially before packing the drug. The final conclusion on all indicators of the quality of finished products is given by the quality control department of the plant. In the conditions of industrial production, the test is carried out in accordance with the requirements of the general article of the State Pharmacopoeia (GF) for ointments, as well as the requirements included in the articles of the GF for individual names of ointments. The ointment is standardized in appearance, uniformity, content of medicinal substances, pH value, degree of dispersion of solid particles, colloidal stability and thermal stability. The company controls the appearance, smell and characteristic organoleptic properties (if any) of ointments and other…

Classification of ointment bases

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Ointments contain medicinal and auxiliary substances that should be evenly distributed in the dosage form. Excipients form a simple or complex base. Thus, the ointment base is the carrier of the medicinal substance. Depending on the composition, it can have an effect on the release, bioavailability and therapeutic effect of the medicinal substance. The bases provide the necessary mass of ointment, proper concentration of medicinal substances, soft consistency and have a significant impact on the stability of ointments. The degree of release of medicinal substances from ointments, the speed and completeness of their resorption largely depend on the nature and properties of the base. For example, an ointment of 2% boric acid on a consistent emulsion basis exhibits the same therapeutic activity as a similar...

Homogenization of ointments and creams

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The next stage in the production of ointments is homogenization. This is a specific stage, since when mixing, the desired degree of dispersion of medicinal substances is not always achieved. For homogenization, various equipment is used, such as roller or disc masers, millstones and colloidal mills, as well as homogenizers-dispersants. Roller mazeterki have two or three rolls with a smooth surface, rotating towards each other at different speeds, ensuring the transition of ointment from shaft to shaft and increasing the friction between them. Rolls are made of porcelain, basalt or metal. To maintain the optimal temperature of the ointment entering the rolls, they are made hollow so that, if necessary, water can be supplied inside. Mazeterka is a system of three rolls in contact with...
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