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Classification of ointment bases

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Classification of ointment bases

Ointments contain medicinal and excipients, which must be evenly distributed in the dosage form. The excipients form a simple or complex base. The ointment base is thus the carrier of the medicinal substance. Depending on the composition, it can influence the release, bioavailability and therapeutic effect of the drug substance. Bases provide the required ointment mass, proper concentration of drug substances, soft consistency and have a significant influence on the stability of ointments. The degree of drug release from ointments, the speed and completeness of their resorption largely depend on the nature and properties of the base.
For example, an ointment of 2% boric acid on a greasy emulsion base shows the same therapeutic activity as a similar ointment of 10% concentration, prepared on petroleum jelly.

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  • Information updated : 09 / 07 / 2024
  • In stock
  • Manufacturer : 1 year for Classification of ointment bases

Model: Ointment bases

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Thus, a large number of different components, less often individual substances, which are usually complex physicochemical systems, are currently used as bases for ointments. Research in this field is expanding every year. The wide range and variety of properties of ointment bases lead to the necessity of their classification. According to the ability to interact with water (dissolution, swelling, absorption, emulsification), ointment bases are divided into three groups: hydrophobic (lipophilic); hydrophilic; diphilic.

Pharmaceutical Glossary

Articles  — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.
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Technical specifications

); hydrophobic solvents (mineral and vegetable oils, isopropyl palmitate, isopropyl myristate, polyalkylsiloxanes, benzyl benzoate, etc.); water and hydrophilic solvents (ethyl and isopropyl alcohols, polyethylene glycols 200-600, propylene glycol, propylene carbonate, glycerin, dimexide, etc.);
emulsifiers of oil-in-water type (sodium lauryl sulfate, emulsifier No. 1, tweens, polyoxyethylene glycol ethers of higher fatty alcohols, salts of higher fatty acids, etc.); emulsifiers of water-in-oil type (higher fatty alcohols, cholesterol, wool wax alcohols, sphenes, glyceryl monooleate, glyceryl monostearate, etc.); gel formers (carboxyethylene glycols, cholesterol, wool wax alcohols, glyceryl monostearate, etc.). ); gelling agents (carbomers, alginic acid and its salts, cellulose derivatives, polyethylene, polyethylene glycols 1500-8000, bentonite, kaolin, gelatin, etc.); antimicrobial preservatives. ); antimicrobial preservatives (miramistin, benzoic and sorbic acids and their salts, ethyl alcohol, propylene glycol, etc.); antioxidants (a-tocopherol, ascorbic acid and its derivative, citric acid, propyl gallate, etc.);
solubilizers f-cyclodextrin, hydrophilic surfactants, etc.); fragrances (menthol, essential oils, phenylethyl alcohol, etc.); pH stabilizers (citric acid, sodium phosphoric acid salts, etc.).

Additional information

Some auxiliary substances can simultaneously perform several of the above functions, as well as included in the composition of ointments as softening and moisturizing additives, penetrators, softeners and others.
Gelling agents, emulsifiers and substances that increase the melting point and viscosity of bases are also stabilizers of disperse systems. Certain auxiliaries are mixtures of different auxiliaries: aqueous lanolin, emulsifier No. 1, non-ionogenic emulsion wax, an alloy of petroleum jelly with alcohols of wool wax, etc.

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