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Coating in drum-type systems ensures gentle processing, especially of temperature-sensitive and fragile dosage forms. For sugar draping as well as for film coating, Glatt uses a method in which a coating solution is applied to the particle from above using a two-component nozzle.
The movement and mixing of the particles in Glatt’s GMPC II is achieved by rotating the drum. The supplied process air evaporates the liquid and dries the layer. Softening and stickiness of the particle surface is prevented by selecting the appropriate process parameters. The required efficient heat exchange is achieved by the continuous perforation of the cylindrical part of the drum, thus minimizing the process time. Significant advantages of Glatjp’s sugar dredging process are gentle mixing and coating of the tablets due to the geometry of the drum and the company’s specially developed Fischer mixing paddles, which ensure absolutely uniform mixing with minimal mechanical impact on the product. With this method of dredging it is possible to coat large, non-fluidizable particles (e.g. tablets, capsules and large pellets). In general, this plant design achieves a high coating quality with throughputs ranging from 500 g to 2000 kg. DGM (Switzerland) has developed a sugar coating plant with an efficient system for spraying the coating medium and drying. The tablets in the rotating perforated drum of the plant make complex orbital movements, during which the coating medium is automatically sprayed over them according to a defined process. At the same time, hot air is fed into the drum, penetrating through the tablet layer, so that the coating medium applied to the*surface of the tablets dries quickly and evenly. In this way, a strong and smooth thin-layer coating is formed.
Pharmaceutical Glossary
Technical specifications
In addition, the ellipsoidal shaped coating machine create optimal rotational movements of the drained tablets, accelerating and improving the coating conditions.
The draining machine rotates in a clockwise direction around an axis located at an inclination (vertical and horizontal mixing) to achieve good mixing. The diameter of the coating, most often made of copper, ranges from 0.7 to 1.5 meters.
The angle of inclination of the coating to the horizontal is 30°-45°, the optimum loading is 25-30 % of the coating volume. Optimum speed of rotation of the coating machine is 20-40 rpm, the number of revolutions are selected depending on the course of the technological process. Stages of the technological process of dragging tablets are as follows: enveloping, or priming; layering, or rolling, – the most important stage, as it is here is mainly the formation of the entire shell; smoothing, or polishing; glossing – the last stage of dragging, at which the tablets are given luster, marketable appearance.
Prof. PD. Pashnev in 1975 developed a new method of coating tablets – suspension method of dragees, the dispersion medium in which is 70% sugar syrup. Polyvinylpyrrolidone (PVP) as a plasticizer, magnesium carbonate as a filler, titanium dioxide as a dye and aerosil to stabilize the suspension.
PVP is a high molecular weight compound, the molecules of which, attaching to each other, form a spatial grid in solution. Sugar molecules dissolved in water are enclosed in the grid cells.
Additional information
In the process of drying the processed tablets, the water in the individual cells is removed. The sugar remaining in the cells, crystallizing, does not have the ability to combine into agglomerates. Fine crystals with low brittleness and high plasticity are formed [2, 3]. BASF suggests the use of Collidon 25 and Collidon 30 in sugar dredging (see section 4.9). The physical characteristics of these substances, such as prevention of microcracking, adhesion of the sugar layer to the tablet core, uniform distribution of dye over the tablet coating, slower and more homogeneous crystallization of the sugar, favor the coating process and improve the quality of the coatings. Sugar coatings are particularly susceptible to cracking when applied to large batches of tablet cores that dry quickly. Since most medecine substances are hydrophobic, Collidon 25 and Collidon 30 are used as additives to prevent cracking-induced peeling of the tablet coating from the tablet core during manufacturing. Table 4.9 shows an example of a slurry composition for automatic sugar coating. The data are shown for 40 kg of 420 mg tablet nuclei in a conventional coating tank when 25 kg of the above-described slurry is atomized under the following conditions: duration of the atomization step – 5 s; interval – 10 min; hot air drying time – 10 min; total coating time -16 hr. A more modern way of sugar dredging process is offered by Glatt company, which uses for this purpose new generation drum machines.
Order status tracking
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 07/05/2024 17:46
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Ella, this chat is only for tracking shipments. 07/05/2024 17:48
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Reykjavik, do you deliver to the terminal or to the actual address? 07/05/2024 17:56
Hello Savannah, we deliver all over USA including to Reykjavik . The price in the catalog includes any delivery our customer asks for. 07/05/2024 17:58
Tell me the NJ-120 automatic capsule machine went ? 07/05/2024 18:06
Lily, good afternoon. Yes, already before lunch you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 07/05/2024 18:07
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to New Orleans. 07/05/2024 18:16
Good day Evelyn, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to New Orleans is included in the price. 07/05/2024 18:17
Good day, delivery time of semi-automatic drum filling machine DF-10 to Perast, will the courier call us? 07/05/2024 18:26
Brooklyn, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 07/05/2024 18:27
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 07/05/2024 18:36
Hello Jackson, Our manager Natalia tomorrow until 18: 30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Leicester in 15 days. 07/05/2024 18:38
RZW-29 rotary tablet press in Geneva. Regards, Owen. 07/05/2024 18:46
Owen, Delivery will be made tomorrow until 16:30 to Geneva . Please have the movers ready. The weight of the equipment is heavy. 07/05/2024 18:49
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 07/05/2024 18:56
Lucas, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 07/05/2024 18:57
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Bruges ? 07/05/2024 19:06
Hello Michael, Expect tomorrow until 12:30. Once received, please let us know. 07/05/2024 19:07
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 07/05/2024 19:16
Chloe, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 07/05/2024 19:18
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS