PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Direct pelletizing involves the creation of pellets directly from a powder with a binder or solvent. This is a fairly fast process that requires a small amount of excipients. In the initial stage, the powder is mixed and moistened. Then, if necessary, a solvent or binder is added, which are sprayed onto the powder particles. The powder layer is driven in a circular motion. As a result of the collisions and accelerations that occur in this case, agglomerates arise, which are rolled to obtain dense pellets of the correct spherical shape. The speed of rotation has a direct effect on the density and size of pellets. Then the wet pellets are dried in a fluidized bed. The advantage of the direct pelletizing method is to obtain round pellets with good fluidity, dosing, dispersibility, compact structure, high bulk weight, dense surface and high abrasion resistance.