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At the same time, they can be used to identify the dosage form. Additionally, some physical properties of the coating, such as moisture resistance, can be improved with dyes. Dyes can be classified into water-soluble dyes and insoluble pigments.
Water-soluble dyes cannot be used in film coatings based on organic solvents, they can only be used in coatings based on aqueous compositions. Pigments are preferred because: they are less likely to affect bioavailability than some water-soluble colorants; they help reduce the water permeability of the coating; and they can be used as fillers to increase the total solid content of the coating dispersion without undesirable increases in viscosity. Solvents. Solvents for film coatings may include: alcohols, ketones, esters, chlorinated hydrocarbons and water. Solvents have an important function in the coating formation process as they help in coating the core surface. A good interaction between the solvent and the polymer is necessary to ensure optimum film properties when the coating dries. This initial interaction between solvent and polymer will maximize the elongation of the polymer chain, which in turn will provide good cohesive strength and thus the best mechanical properties. At the same time, an important function of the solvent system is to provide a controlled distribution of the polymer on the core surface to create a homogeneous coating.
Pharmaceutical Glossary
Technical specifications
Studies have shown that when the HPMC content in the blend is less than 24%, the release profile depends on the rate of water penetration into the coating, which in turn becomes a determining factor in selecting the ratio of polymer concentrations in the blend.
Most of the polymers used are available in a wide range of molecular weights, which is a major factor in the choice of coating technology. Molecular weight can have a significant effect on coating properties such as viscosity, mechanical strength, and film elasticity.
Plasticizers. A plasticizer is a liquid or solid with a high boiling point. Examples of plasticizers include glycerin, propylene glycol, polyethylene glycol, triacetin, esters of citric acid (e.g., triethyl citrate), esters of phthalic acid (e.g., triethyl phthalate). The introduction of a plasticizer can improve the elasticity of the coating Cracking the risk of mechanical damage and potentially in the coating improve the adhesion of the film coating to the core.
When the plasticizer interacts with the polymer, the minimum film formation temperature may be reduced. To form a quality film, the plasticizer must have high compatibility with the polymer and be permanently retained in the coating, especially if the main objective of the coating is the stability of the dosage form during storage.
Additional information
The scientific literature provides numerous examples of the effect of plasticizer concentration on the physicochemical properties of the film coating and on the release of the drug substance from the coated products. For example, high plasticizer content can reduce the release of metoprolol from Eudragit RS coated microspheres and improve the release stability of theophylline from coated microspheres during storage.
Moreover, the release rate of the drug substance has been shown to be influenced by the type of plasticizer. For example, the release of propanolol from microspheres coated with a mixture of ethylcellulose and Eudragit L100-55 is faster when using the hydrophilic plasticizer triethyl citrate than when using the hydrophobic dibutyl sebacinate. Other studies have shown that the plasticizer can leach out of the coating during dissolution, thus affecting both mechanical properties and the release of LVs.
Adhesion of coating substances during film application causes the formation of undesirable aggregates, and the resulting coatings may be damaged when attempts are made to separate adhering parts. This effect can be neutralized by adding anti-adhesion agents to the coating composition or by applying these agents immediately after the spray chamber. Useful anti-adhesion agents include talc, magnesium stearate, kaolin, etc.
Dyes. Dyes are commonly used to improve the appearance of the dosage form.
Order status tracking
Rotary tablet press RZK-25 I want to order with delivery to Berlin 02/05/2024 19:04
Good day, Evelyn We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 02/05/2024 19:06
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 02/05/2024 19:14
Hello Lily, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 02/05/2024 19:15
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 02/05/2024 19:24
Good afternoon, James! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 02/05/2024 19:25
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 02/05/2024 19:34
Hello Sofia, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 02/05/2024 19:36
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 02/05/2024 19:44
Hello Aubrey, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 02/05/2024 19:47
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Tartu ? 02/05/2024 19:54
Good afternoon, Aiden! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 02/05/2024 19:55
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Pittsburgh 02/05/2024 20:04
Hello Amelia, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 02/05/2024 20:07
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 02/05/2024 20:14
Hello Riley, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Oslo to 50 working ( not calendar) days. Action taken. 02/05/2024 20:17
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 02/05/2024 20:24
Hello William, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 02/05/2024 20:28
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Albuquerque ( Europe) ? How much time for delivery ? 02/05/2024 20:34
David, hello! We have many customers from your city. Delivery to this region is made by EMC. 02/05/2024 20:38
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
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- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
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- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES