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In the second step, the agglomeration process takes place due to the formation of solid bridges as a result of sintering of particles, partial melting or crystallization of soluble substances. Next, solid bridges are formed between the particles through chemical reaction, solidification of binders or crystallization of insoluble substances. The dry granulation process is carried out on special equipment. The combined plant combines the processes of compacting, crushing and separating the resulting granules. The principle of operation of the press-granulator is as follows: rotating in different directions, the rollers grasp the powdery mixture and press it through the holes in the wall of the hollow rollers. Inside the hollow rollers, a knife cuts the resulting pellets.
Pharmaceutical Glossary
Technical specifications
The resulting briquettes are crushed using mills, fractionated using sieves and pressed on tablet machines into tablets of a given weight and diameter. It should be noted that dry granulation is used less frequently in tablet manufacturing than wet granulation or direct pressing. The main stages of the dry granulation process are: powder mixing; compacting; grinding; sieving; powdering; blending. Some stages may be omitted. Granulation by briquetting can also be used when the LV has good compressibility and does not require additional particle binding by binders. The number of prescriptions recommending the use of dry binder additives followed by direct pressing has increased significantly.
Additional information
The most well-known method of dry granulation is the compacting method, which compacts dry powder, giving it the shape of granules under some pressure. Nowadays, using the method of dry granulation, dry binders (e.g. microcrystalline cellulose, polyethylene oxide) are introduced into the composition of the tablet mass, providing under pressure the adhesion of both hydrophilic and hydrophobic particles. The bonding of particles to each other occurs under the influence of forces of different nature. At the first stage molecular, electrostatic, magnetic forces act. Then the formation of bonds between particles takes place, after which capillary forces begin to act.
Order status tracking
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Granada ? 06/05/2024 11:04
Hello Stella, Expect after lunch. Once received, please let us know. 06/05/2024 11:06
To what address to send you samples of bottles and caps to send them to the factory ? Regards Samuel. 06/05/2024 11:14
Good day, Samuel We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 06/05/2024 11:16
Tell me the NJ-120 automatic capsule machine went ? 06/05/2024 11:24
Layla, good afternoon. Yes, already between 16:00-18:00 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 06/05/2024 11:25
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 06/05/2024 11:34
Good afternoon, Lucas! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 06/05/2024 11:36
Please inform me about the status of the order Rotary tablet press RZ-10A in Sacramento ? 06/05/2024 11:44
Good afternoon, Daniel. We have contacted the carrier, delivery is scheduled closer to evening. Please let us know when you receive it. Thank you. 06/05/2024 11:45
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Oakland. Thank you. 06/05/2024 11:54
Alexander, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Oakland is scheduled for in the interval from 14:00-16:00. Please notify us upon receipt. 06/05/2024 11:58
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 06/05/2024 12:04
Hello Layla, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 06/05/2024 12:04
Good afternoon, please confirm that as agreed we will receive our shipment in London? Contact the transportation company. 06/05/2024 12:14
Hello Hannah ! Representatives of the transportation company on the delivery status of your shipment said that it will be in London in a few days. Please expect it. 06/05/2024 12:17
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Philadelphia 06/05/2024 12:24
Hello Carter, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 06/05/2024 12:27
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled in the interval from 10:00-12:00 to open the box and test. 06/05/2024 12:34
Aria, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 06/05/2024 12:36
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC CARTONING MACHINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR MIXING POWDERS