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Pure solvents (water, ethanol) are used as binders, as they partially dissolve the tabletting material; natural gum (acacia, tragacanth), gelatin, sugar (in the form of syrups with a concentration of 50-67%), starch glue, cellulose derivatives, alginic acid, irlginates. Most often as a “binding agent in pharmaceutical enterprises is used 5% starch glue. Studies have shown that as the concentration of the binder solution increases, the disintegration of tablets and the rate of release of the drug substance deteriorates. This applies to substances such as starch glue, sodium carboxymethylcellulose salt (Na CMC), polyethylene oxide (PEO) and gelatin. As for polyvinylpyrrolidone (PVP) and sodium alginate, increasing their amount improves the release of the drug substance. Consequently, for each tabletting material it is advisable to select the optimal quantitative and qualitative composition of binders to obtain the best mechanical properties of granulate and tablets, at the same time to ensure the required disintegration and release rate of the drug substance.
Pharmaceutical Glossary
Technical specifications
Fillers with good bulkiness and pressability are used for direct pressing. Binders. Particles-most of the drug substances have a small adhesive force between themselves, so their tableting requires the application of high pressure, which is partly responsible for the untimely wear of the press tools of tablet machines (dies and punches) and the production of poor-quality tablets. In order to achieve the necessary bonding force at relatively low pressures, binders are added to the tabletting substances. Their function is that by filling the interparticle space, they increase the contact surface of the particles and the cohesion capacity. Binders are of particular importance in the pressing of complex powders. In the process of tablet machine operation, they can delaminate, resulting in tablets with different content of incoming ingredients. The use of a certain type of binders and their quantity depend on the physicochemical properties of the substances to be pressed. The function of binders can be performed by various substances.
Additional information
Water is used in all cases where simple moistening provides normal granulation of powdery mass. Ethyl alcohol is used for granulation of hygroscopic powders, most often when the composition of the mass for tableting includes dry extracts from plant materials – these substances with water and aqueous solutions form a sticky, sticky, poorly granulated mass. The concentration of alcohol used is usually the higher the more hygroscopic the powder. Navy solutions are used for powders that form crumbly, non-pelletizable masses with water and alcohol. The binding capacity is determined not only by the concentration of the solutions, but also by the size of the molecules. Binders are introduced into the mass to be pelletized in two ways: dry and wet (i.e., powder and solution). In wet granulation there is a rule: if it is necessary to add a small amount of humectant, the binders are introduced into the mixture in dry form, if the amount of humectant is large, the binder is introduced in the form of a solution. The solubility of the binder also influences the choice of its introduction method.
Order status tracking
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Wichita 03/05/2024 22:52
Hello Mia, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 03/05/2024 22:54
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 03/05/2024 23:02
Good afternoon, David, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 03/05/2024 23:05
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 03/05/2024 23:12
Hello Jayden, Transportation has advised that between 12:00-14:00 driver will definitely deliver the box to your address. We apologize. 03/05/2024 23:14
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 03/05/2024 23:22
Emily, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Los Angeles 15 calendar days. 03/05/2024 23:24
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 15:30 to open the box and test. 03/05/2024 23:32
Grace, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 03/05/2024 23:35
Tell me the NJ-120 automatic capsule machine went ? 03/05/2024 23:42
Ethan, good afternoon. Yes, already in the morning you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 03/05/2024 23:44
Waiting for delivery to Vichy of a TR-02 hard gelatin capsule polishing machine. What about it? 03/05/2024 23:52
Hello Emilia, on your order we inform you that closer to evening the driver will contact you to clarify the time and place of unloading. 03/05/2024 23:54
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 04/05/2024 00:02
Hello Zoe, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 04/05/2024 00:03
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 04/05/2024 00:12
Hello Grace, Our manager Natalya as stipulated in the contract will dial the driver, also we ask you yourself to the transportation company. 04/05/2024 00:15
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to USA, do you deliver to the terminal or to the actual address? 04/05/2024 00:22
Hello Stella, we deliver all over USA including to USA . The price in the catalog includes any delivery our customer asks for. 04/05/2024 00:24
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS