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Pure solvents (water, ethanol) are used as binders, as they partially dissolve the tabletting material; natural gum (acacia, tragacanth), gelatin, sugar (in the form of syrups with a concentration of 50-67%), starch glue, cellulose derivatives, alginic acid, irlginates. Most often as a “binding agent in pharmaceutical enterprises is used 5% starch glue. Studies have shown that as the concentration of the binder solution increases, the disintegration of tablets and the rate of release of the drug substance deteriorates. This applies to substances such as starch glue, sodium carboxymethylcellulose salt (Na CMC), polyethylene oxide (PEO) and gelatin. As for polyvinylpyrrolidone (PVP) and sodium alginate, increasing their amount improves the release of the drug substance. Consequently, for each tabletting material it is advisable to select the optimal quantitative and qualitative composition of binders to obtain the best mechanical properties of granulate and tablets, at the same time to ensure the required disintegration and release rate of the drug substance.
Pharmaceutical Glossary
Technical specifications
Fillers with good bulkiness and pressability are used for direct pressing. Binders. Particles-most of the drug substances have a small adhesive force between themselves, so their tableting requires the application of high pressure, which is partly responsible for the untimely wear of the press tools of tablet machines (dies and punches) and the production of poor-quality tablets. In order to achieve the necessary bonding force at relatively low pressures, binders are added to the tabletting substances. Their function is that by filling the interparticle space, they increase the contact surface of the particles and the cohesion capacity. Binders are of particular importance in the pressing of complex powders. In the process of tablet machine operation, they can delaminate, resulting in tablets with different content of incoming ingredients. The use of a certain type of binders and their quantity depend on the physicochemical properties of the substances to be pressed. The function of binders can be performed by various substances.
Additional information
Water is used in all cases where simple moistening provides normal granulation of powdery mass. Ethyl alcohol is used for granulation of hygroscopic powders, most often when the composition of the mass for tableting includes dry extracts from plant materials – these substances with water and aqueous solutions form a sticky, sticky, poorly granulated mass. The concentration of alcohol used is usually the higher the more hygroscopic the powder. Navy solutions are used for powders that form crumbly, non-pelletizable masses with water and alcohol. The binding capacity is determined not only by the concentration of the solutions, but also by the size of the molecules. Binders are introduced into the mass to be pelletized in two ways: dry and wet (i.e., powder and solution). In wet granulation there is a rule: if it is necessary to add a small amount of humectant, the binders are introduced into the mixture in dry form, if the amount of humectant is large, the binder is introduced in the form of a solution. The solubility of the binder also influences the choice of its introduction method.
Order status tracking
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 22/07/2024 06:45
Good day, Daniel! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 22/07/2024 06:45
PU-250 flow-pack packaging machine, please advise delivery status. 22/07/2024 06:55
Hello Aiden, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow until 15:30 22/07/2024 06:58
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 22/07/2024 07:05
Hello Benjamin, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 22/07/2024 07:07
HX-6 Plastic Tube Filling and Sealing Machine in Helsinki? Price delivery terms and conditions 22/07/2024 07:15
Emily, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/07/2024 07:17
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Milan ? 22/07/2024 07:25
Hello Bella, Expect tomorrow until 15:30. Once received, please let us know. 22/07/2024 07:27
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 22/07/2024 07:35
{The original shipping documents will be delivered to Krakow between 16:00-18:00. Please send the signed copies to us. 22/07/2024 07:38
For shipping to Barcelona do you have to pay anything extra ? 22/07/2024 07:45
Good day Aria, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Barcelona is included. 22/07/2024 07:46
Remember me? There's a delivery in the Stockholm 22/07/2024 07:55
Elijah, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be in the interval from 14:00-16:00 in Stockholm . 22/07/2024 07:57
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Omaha. Please confirm the delivery time. 22/07/2024 08:05
Good afternoon William, your shipment has left. Arrival time In the afternoon. The driver will call you back later. Please organize prompt unloading. 22/07/2024 08:06
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/07/2024 08:15
Good afternoon, Chloe! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/07/2024 08:17
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES