PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Microspheres and pellets technology basics

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6140768

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Microspheres (pellets) are a new type of solid dosage form. Recently, in the pharmaceutical industry, drug manufacturers have been producing microspheres, or pellets (from the English pellet — ball, pellet, pellet), as the final or intermediate type of dosage form for the production of finished dosage forms. Microspheres are increasingly being used in the production of finished medicines, as they have a number of significant and undeniable advantages. Pellets can be tableted with the addition of suitable excipients, they can be the contents of capsules, as well as be part of suspensions. Microspheres (pellets) are agglomerates of fine powders or granules, which, in turn, may consist of medicinal and auxiliary substances. Microspheres are small, spherical or hemispherical solid particles with a diameter of 0.5 to...

Equipment for wet granulation process

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6140919

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The granulate is obtained in the process of granulation of wet mass on special granulator machines. The principle of operation of granulators is that the material is wiped with blades, springy wolves or other devices through a perforated cylinder or mesh. To ensure the wiping process, the machine must operate at an optimal mode without overload so that the wet mass passes freely through the holes of the cylinder or mesh. If the mass is sufficiently moistened and moderately plastic, then it does not seal the holes and the process goes without difficulty. If the mass is viscous and seals the holes, the machine works with overload and it is necessary to periodically turn off the motor and rinse the drum blades. The granulator contains...

Fluidized bed coating application

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6139633

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The application of film coatings is carried out in apparatuses for combined granulation, drying and coating processes. A distinctive feature is the lower location of the nozzle. There are two possible ways of organizing the process: applying a film coating directly to crystals or granules containing a medicinal substance; conducting a preliminary stage — layering the medicinal substance on inert particles (pellets are most often used), after which a film coating is applied. During the coating process, a layer of particles is placed in a fluidized bed apparatus.

Filling gelatin capsules with powders and granules

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6139400

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The reproduction and accuracy of dosing depends on the characteristics of the filler, the filling method and the type of filling machine. Active substances for filling into solid gelatin capsules must meet the following requirements: the contents must be released from the capsule, providing high bioavailability; when using automatic filling machines, active substances must have certain physico-chemical and technological properties, such as: certain particle size and shape; the same particle size; mixing homogeneity; flowability (fluidity); moisture content; ability to form compactly under pressure. To fill solid gelatin capsules, machines of various companies are used, differing in performance, dosing accuracy and the structure of the dispenser.

Methods of industrial production of gelatin capsules

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6139299

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There are three main methods of industrial production of gelatin capsules: immersion method, rotary matrix and drip. It should be noted that for the production of solid capsules, the dipping method has found wide application in industry, being essentially the only one. However, to obtain soft gelatin capsules (with drip sealing), the method is currently used only in laboratory conditions, as it is low-productivity and time-consuming. The stamping method, or rotary matrix, is used for the production of soft gelatin capsules and is the most rational for their production in industrial production. The principle of the method is to first obtain a gelatin tape, from which capsules are stamped on the rolls immediately after they are filled and sealed.

Classification of ointments by type of dispersed systems

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6140024

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From the point of view of technology (production cycle), as well as the physico-chemical nature of the basis and the nature of the distribution of medicinal substances in the basis, the classification of ointments by the type of dispersed systems is of the greatest importance. According to this classification, homogeneous and heterogeneous ointments are distinguished. Homogeneous ointments are characterized by the absence of an interfacial interface between medicinal substances and the base. In such ointments, medicinal substances are distributed in the base according to the type of solution, i.e. brought to molecular or micellar dispersion. Depending on the method of preparation, these can be: ointments-alloys, which are a combination of several fusible mutually soluble components; ointments-solutions that contain medicinal substances dissolved in the base; extraction...

Classification of ointment bases

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6140015

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Ointments contain medicinal and auxiliary substances that should be evenly distributed in the dosage form. Excipients form a simple or complex base. Thus, the ointment base is the carrier of the medicinal substance. Depending on the composition, it can have an effect on the release, bioavailability and therapeutic effect of the medicinal substance. The bases provide the necessary mass of ointment, proper concentration of medicinal substances, soft consistency and have a significant impact on the stability of ointments. The degree of release of medicinal substances from ointments, the speed and completeness of their resorption largely depend on the nature and properties of the base. For example, an ointment of 2% boric acid on a consistent emulsion basis exhibits the same therapeutic activity as a similar...

Ointments, requirements for ointments and their classification

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6140018

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Of soft medicines for external use, ointments are most often used, which consist of an ointment base and a medicinal substance evenly distributed in it. Ointments are soft medicines for topical use, the dispersion medium of which, at a set storage temperature, has a non—Newtonian type of flow and high values of rheological parameters. They are highly viscous liquids capable of forming a smooth continuous film on the surface of the skin or mucous membrane. Ointments are the official dosage form intended for application to the skin, wound or mucous membranes. Despite the fact that ointments belong to the oldest medicinal forms mentioned in the Ebers papyrus, the works of Hippocrates, Galen and Avicenna, they have not lost their significance today, in modern medicine.

Classification of ointments by purpose

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6140020

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Depending on the purpose of the ointment is divided into the following groups: medical ointments — ointments used for treatment, prevention, diagnosis in dermatology, ophthalmology, cardiology, dentistry, obstetrics, gynecology and other areas of clinical medicine. Cosmetic ointments — decorative, therapeutic, hygienic, for professional cosmetics - are used to soften and nourish the skin. The vitamins contained in them bring these ointments closer to therapeutic ones. Protective ointments — ointments used as personal protective equipment, ointments-films. They are used to protect hands and exposed parts of the body from the effects of chemical irritants in production and in everyday life. Electrode ointments are ointments and pastes for registering biological currents (physiotherapy, encephalography, electrocardiography, etc.). Their role is to fix the electrodes on the body, as well...

Classification of patches by composition

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6140364

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According to the composition of the adhesive masses, plasters are divided into ordinary and rubber. Ordinary plasters (Emplastra Ordinarid) are divided into lead, lead-resin, lead-wax and resin-wax depending on the substances prevailing in the plaster base. These patches contain lead soap as a mandatory component, which has the following positive properties: it has no hardness, is easily fused with resins, waxes and various medicinal substances, and is also stable during storage. A negative property of lead soaps is their non-indifference. A simple lead plaster (Emplastrum Plumbi simplex). The group of lead patches includes a simple lead patch, which is chemically a mixture of lead salts of higher fatty acids (stearic, palmitic and oleic), and also contains traces of unsaponified fats and no more than 3%…