PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Industrial production of plasters

7921

6796658

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Adhesive plasters "Uniplast fixing", "Bactericidal Veropharm" and "Uniplast bactericidal" Modern industrial production of plasters is characterized by a wide range of products. Therefore, it is not possible to consider in detail in one section the production of all types of plasters. In order to understand the specifics of the technological production of plasters, as well as to get acquainted with the main types of equipment used, as an example, consider the production of adhesive plasters "Uniplast fixing", "Bactericidal Veropharm" and "Uniplast bactericidal", organized at the Voronezh Chemical and Pharmaceutical Plant, which is part of JSC "VEROPHARM". The adhesive plaster "Uniplast fixing" is produced in accordance with international quality standards. It is hypoallergenic, has high breathability, is easily and painlessly removed, easily tears without using scissors...

Pelletizing by layering

7963

6797078

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Microspheres can also be made by layering a medicinal substance on inert microspheres. The layering process is a sequential application of layers of a medicinal substance from a solution, suspension or dry powder to the nuclei. The nuclei can be crystals or granules of the same material or inert particles. When layered from a solution or suspension, the particles of the medicinal substance are dissolved or suspended in a liquid. When the powder is layered, complete dissolution does not occur due to the small amount of liquid, regardless of the solubility of the active component in the liquid. When powder coating of the drug, the binder solution is first sprayed onto the inert nuclei, and then the powder is applied. By adding a layer-forming component,...

Equipment for combined processes

7978

6797220

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The SG type apparatus manufactured by NPO "Pharmedobrazovanie" is used for granulation of powders in a fluidized bed, subsequent drying and dusting. This process is periodic. The body of the device is made of three all-welded sections, sequentially mounted with each other. The principle of operation is as follows: 30 kg of tablet mixture to be granulated is loaded into the food tank in accordance with the recipe. The trolley with the initial components is rolled into the machine and lifted. The air temperature required for fanulation is set, the mixing, fanulation and drying time is set, as well as the cyclicity and frequency of shaking of bag filters. The fan is turned on with the help of a gate that regulates the flow of...

Spray drying method (physicochemical microencapsulation method)

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6797377

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The method of spray drying of the dispersion or emulsion of the encapsulated substance containing polymer and solvent (both organic and aqueous) consists in their dispersion into the flow of a coolant gas. As a result of heat and mass transfer, the solvent is removed from the system and dense particles are formed, the encapsulated substance in which is distributed throughout the volume, and not concentrated in the capsule core. The most widespread groups of substances used for encapsulation by spray drying are carbohydrates, including modified and hydrolyzed starches, cellulose derivatives, gums and cyclodextrins; proteins, including whey proteins, casein and gelatin; biopolymers. The type of shell material used affects not only the encapsulation efficiency, but also the morphology of the product particles.

Extrusion method (physical microencapsulation method)

7996

6797408

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During microencapsulation by extrusion, a thin viscous film of film-forming material is formed on the surface with small diameter holes, through which the encapsulated substance is pressed. The shell formed in this way is further stabilized by cooling or polymerization of its constituent monomers. For microencapsulation by extrusion, forming devices are also used, which are two coaxially arranged tubes of different diameters (a "pipe in a pipe" device). The encapsulated material is fed into the inner hole of the tube under pressure, and the shell material is fed into the inter—tube space.

Method based on the use of polymers and crosslinking agents

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6797440

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Crosslinking of polymer chains is carried out by introducing special substances into the system, which, as a result of ion exchange, form bonds between two neighboring chains. In this case, the process takes place at the interface of the phases. It is possible to use oil-in-water systems containing a hydrophilic polymer and, for example, lower aldehydes as crosslinking agents. In this case, the interaction of the polymer with the aldehyde occurs in the aqueous phase, resulting in the formation of a new phase deposited on oil droplets, since the higher aldehydes dissolve in the non-polar phase.

Microspheres and pellets technology basics

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6797058

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Microspheres (pellets) are a new type of solid dosage form. Recently, in the pharmaceutical industry, drug manufacturers have been producing microspheres, or pellets (from the English pellet — ball, pellet, pellet), as the final or intermediate type of dosage form for the production of finished dosage forms. Microspheres are increasingly being used in the production of finished medicines, as they have a number of significant and undeniable advantages. Pellets can be tableted with the addition of suitable excipients, they can be the contents of capsules, as well as be part of suspensions. Microspheres (pellets) are agglomerates of fine powders or granules, which, in turn, may consist of medicinal and auxiliary substances. Microspheres are small, spherical or hemispherical solid particles with a diameter of 0.5 to...

Equipment for wet granulation process

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6797209

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The granulate is obtained in the process of granulation of wet mass on special granulator machines. The principle of operation of granulators is that the material is wiped with blades, springy wolves or other devices through a perforated cylinder or mesh. To ensure the wiping process, the machine must operate at an optimal mode without overload so that the wet mass passes freely through the holes of the cylinder or mesh. If the mass is sufficiently moistened and moderately plastic, then it does not seal the holes and the process goes without difficulty. If the mass is viscous and seals the holes, the machine works with overload and it is necessary to periodically turn off the motor and rinse the drum blades. The granulator contains...

Fluidized bed coating application

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6795923

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The application of film coatings is carried out in apparatuses for combined granulation, drying and coating processes. A distinctive feature is the lower location of the nozzle. There are two possible ways of organizing the process: applying a film coating directly to crystals or granules containing a medicinal substance; conducting a preliminary stage — layering the medicinal substance on inert particles (pellets are most often used), after which a film coating is applied. During the coating process, a layer of particles is placed in a fluidized bed apparatus.

Filling gelatin capsules with powders and granules

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6795690

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The reproduction and accuracy of dosing depends on the characteristics of the filler, the filling method and the type of filling machine. Active substances for filling into solid gelatin capsules must meet the following requirements: the contents must be released from the capsule, providing high bioavailability; when using automatic filling machines, active substances must have certain physico-chemical and technological properties, such as: certain particle size and shape; the same particle size; mixing homogeneity; flowability (fluidity); moisture content; ability to form compactly under pressure. To fill solid gelatin capsules, machines of various companies are used, differing in performance, dosing accuracy and the structure of the dispenser.