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From the physicochemical point of view, the phenomenon of coacervation is caused by intra- and intermolecular interaction involving polyelectrolyte ions or polyelectrolytes, leading to a change in the conformation of polyelectrolyte macromolecules in solution, the degree of their hydration and, as a consequence, to a decrease in their solubility. Coacervation in the interaction of a polymer solution and a low molecular substance is called simple. It is based on the physicochemical mechanism of sticking, “raking into a pile” of dissolved molecules and separation of water from them with the help of water-removing agents. Simple coacervation is caused by adding inorganic salts or other lyophilic substances, as well as by changing the temperature or diluting the system. Complex coacervation is observed when two or more polymers, whose macromolecules carry opposite charges, interact and neutralize each other.
Pharmaceutical Glossary
Technical specifications
In addition, different materials have different drying rates and under the same encapsulation process conditions, products will have different residual moisture contents. All this affects product storage and tendency to agglomeration. The polymers used as encapsulation material were poly-ortho ester (ROE – poly(ortho ester)), a,1-so-polymer of lactic and glycolic acids (PLGA – poly(dl-lactide-co-glycolide)) and their blends with different percentages. It can be seen that when using ROE, particle agglomeration is minimal, while particles containing PLGA stick together after 6 h. When using polymer blends, the degree of particle agglomeration varies depending on the proportion of polymers: particles containing PLGA 80 % are less prone to agglomeration.
Additional information
However, it is noted that after 5 days, pores are formed on the surface of the particles, which subsequently increase in size and negatively affect the preservation of the encapsulated substance. Due to the relatively high economy and productivity of the process, food additives, flavorings, probio-tic, aromatic oils, antibiotics, enzymes and other substances are encapsulated by this method. Physicochemical methods utilize the phenomenon of coacervation. Coacervation (from the Latin word acervus, meaning accumulation or union) is the formation of droplets enriched with dissolved substance in a solution of high-molecular compounds. The merging of the formed droplets leads to the separation of the system into two equilibrium liquid layers: a layer with a low content of polyelectrolyte and a layer with an increased concentration of polyelectrolyte, called the coacervate layer.
Order status tracking
Mixer with paddle for powders CX-100 what is the exact packing size ? 02/05/2024 21:34
Maya, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 02/05/2024 21:38
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled as stipulated in the contract to open the box and test. 02/05/2024 21:44
Mia, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 02/05/2024 21:46
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 02/05/2024 21:54
Mila, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 02/05/2024 21:56
I've been calling your office since this morning, and no one's picking up the phone. 02/05/2024 22:04
Good afternoon, William! The office will be open from 9:00 GMT. We'll be in touch. 02/05/2024 22:04
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 02/05/2024 22:14
Good afternoon Michael, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. In the afternoon we will get a reply from the manufacturer on the final time frame. 02/05/2024 22:18
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 02/05/2024 22:24
Ella, Checking delivery status. The shipment is already in York warehouse. Please arrange for pickup. 02/05/2024 22:26
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Constance, but immediately upon arrival send it to Cinque Terre. 02/05/2024 22:34
Hello Elijah, we will try to resolve this issue for you. 02/05/2024 22:38
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Ljubljana, do you deliver to the terminal or to the actual address? 02/05/2024 22:44
Hello Amelia, we deliver all over USA including to Ljubljana . The price in the catalog includes any delivery our customer asks for. 02/05/2024 22:47
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 02/05/2024 22:54
Layla, Checking delivery status. The shipment is already in Venice warehouse. Please arrange for pickup. 02/05/2024 22:58
Good day, delivery time of semi-automatic drum filling machine DF-10 to Ljubljana, will the courier call us? 02/05/2024 23:04
Michael, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 02/05/2024 23:06
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS