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Consequently, it is possible to minimize potential side effects without reducing the bioavailability of the drug substance. At the same time, high localized concentrations, as in the case of single-element dosage forms, and therefore irritations in localized areas of the gastrointestinal tract can be avoided.
The main reason for the widespread use of multi-element products is the rapidly increasing popularity of controlled-release oral dosage forms.
Solid dosage forms with controlled release of the drug substance are most often used both to deliver the drug substance to a specific area of the gastrointestinal tract and to maintain the action of the active ingredient for a prolonged period of time.
In the case of microspheres, the above objectives can be achieved by using coating materials (mainly various polymers) that provide the described properties or by creating microspheres with a matrix structure.
Pharmaceutical Glossary
Technical specifications
Regardless of the production method, the microspheres must meet (the following requirements: close to spherical shape and smooth surface. These conditions are essential for further coating in an optimal manner; particle sizes should not vary greatly.
The optimum particle size of microspheres for use in pharmaceutical needs is between 600 and 1000 µm; microspheres should contain the highest possible amount of active ingredient.
In the last twenty years, microspheres have strengthened their position in the pharmaceutical industry due to many reasons. Pellets have high density and abrasion resistance, are well suited for automatic dosing, and their particle size distribution lies within a wide size range.
From a technological point of view, microspheres make the process of creation and production of solid dosage forms more flexible. They are able to flow freely and compact without any difficulties, which determines the homogeneity and reproducibility of the average mass of tablets and capsules.
Additional information
Due to the fact that microspheres have a spherical shape and minimal specific surface area, they are ideal for coating. At the same time, a single dosage form can contain microspheres with different drug substances.
This ability allows two or more active ingredients, chemically compatible or incompatible, absorbed in the same or different parts of the gastrointestinal tract to be combined in the same dosage form.
The same dosage form may contain microspheres having different release rates of the drug substance, which allows the release of the active ingredient to be programmed and controlled and the therapeutic action to be delivered with a greater degree of efficacy.
Pelletized drugs can improve the safety and efficacy of the active ingredient. These multi-element dosage forms, usually presented in the form of suspensions, capsules or disintegrating tablets, have several advantages over single element dosage forms.
Pelletized forms are able to distribute freely in the gastrointestinal tract as single particles, which maximizes absorption and reduces peak changes in plasma drug concentration.
Order status tracking
Mixer with paddle for powders CX-100 what is the exact packing size ? 07/05/2024 17:13
Michael, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 07/05/2024 17:14
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 07/05/2024 17:23
Hello Oliver, Our manager Natalia tomorrow until 18: 30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Tossa de Mar in 15 days. 07/05/2024 17:25
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Edinburgh? Urgent. 07/05/2024 17:33
Aria, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 07/05/2024 17:37
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled in the interval from 10:00-12:00 to open the box and test. 07/05/2024 17:43
Savannah, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 07/05/2024 17:44
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 07/05/2024 17:53
Hello Chloe, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 07/05/2024 17:55
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 07/05/2024 18:03
Joseph, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 07/05/2024 18:06
Remember me? There's a delivery in the Dublin 07/05/2024 18:13
Wyatt, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be after lunch in Dublin . 07/05/2024 18:14
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 07/05/2024 18:23
Hello Sebastian, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 07/05/2024 18:27
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Helsinki, do you deliver to the terminal or to the actual address? 07/05/2024 18:33
Hello Aurora, we ship all over Europe and the US including to Helsinki . The price in the catalog includes any delivery our customer asks for. 07/05/2024 18:34
Good afternoon, please confirm that between 16:00-18:00 we will receive our shipment in Geneva? Contact the transportation company. 07/05/2024 18:43
Hello Zoe ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Geneva in a few days. Please expect it. 07/05/2024 18:46
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- FLOW-PACK PACKAGING MACHINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES