MAKING SUPPOSITORIES IN PRODUCTION

Molding of suppositories in production

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Currently, automatic machines are widely used in the industry for pouring suppositories, which produce suppositories in contour cell packages. This package is intended for packaging the suppository mass into contour cells with subsequent sealing, coding and cutting into strips of the required length. At medium-capacity enterprises, machines for the production of suppositories use pre-molded tape, since the molding unit is quite expensive, difficult to set up and has high operating costs. Therefore, the use of such a node in machines with low performance is low-profitable. The use of pre-molded tape allows you to reduce the area occupied by the machine and simplify the production process, since there is no need to supply compressed air, water and ventilation, as well as to remove odors formed during…

Standardization of suppositories in the pharmaceutical industry

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All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. The uniformity of the suppository is checked visually on the longitudinal section by the presence or absence of inclusions, pieces of the "base, particles of various colors, other inclusions; at the same time, the presence of an air rod is permissible. Deviations in the mass of suppositories are allowed within 5%. Suppositories must have the correct uniform shape. In suppositories, medicinal substances must be precisely dosed. Suppositories should have a hardness that ensures ease of use.

Suppository bases and their requirements

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From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed when the medicinal substance is dissolved in the base. Heterogeneous systems are formed in the case of the introduction of medecine into the base by the type of emulsion or suspension. In the structure of suppositories, there are basic (medicinal substances) and auxiliary (carriers or base) components. There are a number of requirements for suppository bases: the bases must maintain sufficient hardness at room temperature; the melting (dissolution) temperature of the...

Preparation of suppository base

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The stage of preparation of the suppository base begins with the weighing of its components. In the first stainless steel reactor with a steam jacket, paraffin is melted, in the second reactor, hydrofluid is melted by supplying steam to the steam jacket. The heated hydrofluid is pumped into a reactor with pre-melted paraffin. The mixture is heated to a temperature of 60-70 °With and add cocoa butter. In order to avoid changing the modification of cocoa butter, the heating should not exceed 70 ° C and be prolonged. After the base is completely melted, it is stirred for 40 minutes using a stirrer. In the finished base, the melting point and the time of complete deformation are determined.

Industrial production of suppositories

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There are several methods of making suppositories, among them: rolling out, pressing and pouring the molten mass into molds. The rolling out method is often used in pharmacy practice. This method is labor-intensive, low-hygienic, and the resulting suppositories differ slightly in appearance. Waxed capsules are used as packaging for suppositories. The pressing method makes it possible to produce suppositories like tablets in eccentric (crank) tablet machines using matrices and punches of the appropriate shape. The production of such suppositories is based on the transformation of fat suppository masses into powder form, which allows it to pour out freely from the loading funnel. To achieve the accuracy of dosing and the necessary flowability, the suppository mass is cooled in the refrigerator to a temperature of 3-5...

Introduction of medicine substances into the suppository base

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There are three ways of introducing medicinal substances into the suppository base, which are determined by the physico-chemical properties of the components: All water-soluble components are introduced in the form of aqueous solutions; fat-soluble substances are introduced in the form of fat solutions; substances insoluble in water and fats are introduced in the form of suspensions of powders ground in the bases. The resulting solutions or suspensions are called concentrates.