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Industrial production of suppositories

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Industrial production of suppositories

There are several methods of making suppositories, among them: rolling out, pressing and pouring the molten mass into molds. The method of rolling out is often used in pharmacy practice. This method is labor-intensive, malohygienic, and the resulting suppositories are slightly different in appearance. Waxed capsules are used as packaging for suppositories. The pressing method allows to produce suppositories like tablets in eccentric (crank) tablet machines, using matrices and punches of appropriate shape. The production of such suppositories is based on the transformation of fatty suppository masses into the form of powder, which allows it to freely pour out of the loading hopper. To achieve accurate dosing and the necessary bulkiness suppository mass is cooled in a refrigerated chamber to a temperature of 3-5 ° C, crushed and sieved through a sieve.

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  • Information updated : 09 / 07 / 2024
  • In stock
  • Manufacturer : 1 year for Industrial production of suppositories

Model: Manufacture of suppositories

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Pouring the molten mass into molds is the main method of industrial production of suppositories. Technological scheme of suppository production includes four stages: preparation of suppository base; introduction of drug substances into the base; suppository molding; packing and packaging of suppositories. It should be noted that the production of suppositories necessarily includes a preparatory stage, which is carried out preparation of reactors, containers, collectors, pumps and other equipment by thoroughly treating them with hot steam, water with detergents, rinsing and drying. Sanitization of premises and preparation of working personnel is also carried out.

Pharmaceutical Glossary

Articles  — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.
Blog Business Business plan Buy a business Commerce Company Equipment catalog Innovation Investments Manufacture of suppositories Medications Medicinal substances Melting Analyzer Molding of suppositories Novelty Pharmaceutical equipment Preparation of suppository base Production Requirements for suppository bases Startup Suppository base Suppository line

Technical specifications

A third main part was added – the loading hopper, which alternates with the upper punch in a progressive-return motion and fills the matrix slot. This type of tablet machines with a resting matrix and a movable feed hopper by the type of mechanism driving the punches, was called eccentric, or crank. Scheme of crank tablet machine, which is a single-position press with a drive from the main crankshaft. Pressing is carried out by cooling the punch, die and shroud. The advantages of the pressing method are in the possibility of preventing the destruction of thermolabile drug substances, in the absence of sedimentation of the active substance and preventing its incompatibility with the molten base. The pressing method is used in the production of suppositories with cardiac glycosides, some thermolabile hormonal drugs and biogenic stimulants, as the process of preparation provides high accuracy of dosage and thermostability of drugs.

Additional information

The filter baffle is located on the false bottom. The resulting sludge is washed, dried and discharged by means of an agitator through a hatch located on the side of the housing or in the center of the false bottom. In some designs, the sludge is removed after lowering the false bottom by moving the filter cloth belt, which passes through the regeneration chamber at the end of the sludge discharge. Druk filters are known, the body of which can be rotated by 90-180° in the trunnions fixed on its cylindrical part. Druk filters are used to separate medium and well-filtered suspensions in medium and low-tonnage productions.

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