СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of pellet formation and growth. Some theories have been derived from experimental data, while others have been inferred from visual observations. Conventional granulation as the most fully studied and categorized process of microsphere formation, conducted using different equipment, has been divided into three successive stages: core formation stage, transition stage, and sphere growth stage. However, based on experiments on the mechanism of microsphere formation and growth, the following microsphere growth mechanisms have been proposed: nucleus formation, bonding, layering and friction transfer.

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Information updated: 28 / 07 / 2026
Available for
Production: 1 year на оборудование для пеллетирования на фармацевтическом производстве

Model: Pelletizing in pharmaceutical production

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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.

Additional information

The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.

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David
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 03/08/2026 01:45

Roman Tsibulsky
Hello David, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 03/08/2026 01:48

Samuel
For shipping to Crete do you have to pay anything extra ? 03/08/2026 01:55

Roman Tsibulsky
Good day Samuel, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Crete is included. 03/08/2026 01:55

Emma
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Bratislava? Urgent. 03/08/2026 02:05

Roman Tsibulsky
Emma, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 03/08/2026 02:07

Amelia
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 03/08/2026 02:15

Roman Tsibulsky
Hello Amelia, Our manager Natalia In the afternoon will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Alexandrovka in 15 days. 03/08/2026 02:15

Scarlett
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 03/08/2026 02:25

Roman Tsibulsky
Hello Scarlett, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Tempe . 03/08/2026 02:28

Henry
Good day, tell me need delivery in Stockton to the settlement in the distance of 20 km. Can you organize this? 03/08/2026 02:35

Roman Tsibulsky
Henry, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 03/08/2026 02:37

Ethan
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Tallinn, then I want to buy an automatic capsule machine model GN-28 03/08/2026 02:45

Roman Tsibulsky
Good afternoon, Ethan! On the first question - the shipment will arrive in Tallinn the day after tomorrow. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 03/08/2026 02:49

Sophia
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 03/08/2026 02:55

Roman Tsibulsky
Sophia, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Milwaukee 15 calendar days. 03/08/2026 02:58

James
Waiting for delivery to Lucca of a TR-02 hard gelatin capsule polishing machine. What about it? 03/08/2026 03:05

Roman Tsibulsky
Hello James, on your order we inform you that after lunch the driver will contact you to clarify the time and place of unloading. 03/08/2026 03:09

Penelope
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Wichita. We want to track the delivery status. 03/08/2026 03:15

Roman Tsibulsky
Penelope, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 03/08/2026 03:15