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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.
Pharmaceutical Glossary
Technical specifications
Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.
Additional information
The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.
Order status tracking
Good afternoon, I am hoping in the morning to get the UNIC 600A Tablet Press in Gjirokastra ! Please comment. 27/04/2024 21:38
Good day, Natalie! Our manager has communicated with the delivery service, the equipment will be delivered to Gjirokastra at your address. Please let us know when you receive it. 27/04/2024 21:40
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 27/04/2024 21:48
Lily, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Baltimore ? Contact Natalia, she will send the contract and invoice. 27/04/2024 21:49
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Oslo? Urgent. 27/04/2024 21:58
Zoey, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 27/04/2024 21:58
Good day, tell me need delivery in Jacksonville to the settlement in the distance of 20 km. Can you organize this? 27/04/2024 22:08
Hannah, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 27/04/2024 22:10
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Las Vegas 27/04/2024 22:18
Hello Sophia, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 27/04/2024 22:21
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Leicester. 27/04/2024 22:28
Hello Ella, Delivery status checked, as agreed is arriving at Leicester . The driver will call you beforehand. 27/04/2024 22:30
For shipping to Lisbon do you have to pay anything extra ? 27/04/2024 22:38
Good day Maya, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Lisbon is included. 27/04/2024 22:42
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 27/04/2024 22:48
Liam, Checking delivery status. The shipment is already in Prague warehouse. Please arrange for pickup. 27/04/2024 22:49
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 27/04/2024 22:58
Henry, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 27/04/2024 22:59
RZW-29 rotary tablet press in Bratislava. Regards, Elijah. 27/04/2024 23:08
Elijah, Delivery will be made tomorrow until 14:30 to Bratislava . Please have the movers ready. The weight of the equipment is heavy. 27/04/2024 23:09
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING