СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / PHARMACEUTICAL PELLET MICROSPHERES / Pelletizing in pharmaceutical production

Pelletizing in pharmaceutical production

To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of pellet formation and growth. Some theories have been derived from experimental data, while others have been inferred from visual observations. Conventional granulation as the most fully studied and categorized process of microsphere formation, conducted using different equipment, has been divided into three successive stages: core formation stage, transition stage, and sphere growth stage. However, based on experiments on the mechanism of microsphere formation and growth, the following microsphere growth mechanisms have been proposed: nucleus formation, bonding, layering and friction transfer.

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Information updated: 09 / 08 / 2026
Available for
Production: 1 year на оборудование для пеллетирования на фармацевтическом производстве

Model: Pelletizing in pharmaceutical production

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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.

Additional information

The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.

Order status tracking

Roman Tsibulsky +79853643808 now online

Mia
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Amsterdam ? 23/08/2026 05:12

Roman Tsibulsky
Hello Mia, your shipment is in the customs warehouse, tomorrow until 18: 30 your manager Natalia will contact you. 23/08/2026 05:13

Hannah
Please inform me about the status of the order Rotary tablet press RZ-10A in Pittsburgh ? 23/08/2026 05:22

Roman Tsibulsky
Good afternoon, Hannah. We have contacted the carrier, delivery is scheduled in the interval from 10:00-12:00. Please let us know when you receive it. Thank you. 23/08/2026 05:24

Natalie
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Valletta. 23/08/2026 05:32

Roman Tsibulsky
Hello Natalie, Delivery status checked, tomorrow until 16:30 is arriving at Valletta . The driver will call you beforehand. 23/08/2026 05:32

Natalie
Good day, delivery time of semi-automatic drum filling machine DF-10 to Ljubljana, will the courier call us? 23/08/2026 05:42

Roman Tsibulsky
Natalie, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 23/08/2026 05:45

Elijah
To what address to send you samples of bottles and caps to send them to the factory ? Regards Elijah. 23/08/2026 05:52

Roman Tsibulsky
Good day, Elijah We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 23/08/2026 05:53

Isabella
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 23/08/2026 06:02

Roman Tsibulsky
Hello Isabella, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 23/08/2026 06:05

Layla
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Colorado Springs. Thank you. 23/08/2026 06:12

Roman Tsibulsky
Layla, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Colorado Springs is scheduled for In the afternoon. Please notify us upon receipt. 23/08/2026 06:14

Michael
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 23/08/2026 06:22

Roman Tsibulsky
Michael, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Columbus ? Contact Natalia, she will send the contract and invoice. 23/08/2026 06:24

Layla
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to El Paso. We want to track the delivery status. 23/08/2026 06:32

Roman Tsibulsky
Layla, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 23/08/2026 06:33

Wyatt
Good afternoon, I am hoping in the interval from 10:00-12:00 to get the UNIC 600A Tablet Press in Stavanger ! Please comment. 23/08/2026 06:42

Roman Tsibulsky
Good day, Wyatt! Our manager has communicated with the delivery service, the equipment will be delivered to Stavanger at your address. Please let us know when you receive it. 23/08/2026 06:42