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Fragments or dust generated by friction, damage or destruction of particles are deposited on the larger microspheres. Dust formation and subsequent bonding and layering continue until the number of favorable collisions begins to decrease rapidly, resulting in a decrease in the growth rate of the microspheres. At this point, the third stage of pelletizing, the microsphere growth stage, begins. The main mechanism of this stage, which affects the slow growth of agglomerates, is frictional material transfer, involving the transfer of material from one pellet to another in either direction. There is no change in the total number or mass of particles during this stage.
Pharmaceutical Glossary
Technical specifications
Nucleus formation is a common mechanism in all pellet formation processes – pelletization/granulation and occurs when the powder is wetted. The primary particles are connected to each other to form three-phase nuclei (air – water – particle) by means of liquid bridges. The strength of the bonding increases as the size of the -particle decreases. The size of the primary particles, their moisture content, the viscosity of the bonding particles, the wettability of the material and the processing conditions (mixing and drying rate) influence the size of the nuclei and the degree of nuclei formation. The mass and number of nuclei in the system are important characteristics of the nuclei formation stage and change in time.
Additional information
The nucleus formation stage is followed by a transition phase in which bonding and layering are involved as mechanisms of microsphere growth. Coupling is defined as the formation of larger particles by random collisions of the formed nuclei with a small excess moisture on the nucleus surface. Although the number of nuclei gradually decreases, the total mass of the system remains constant during this stage. Overlaying is a slow mechanism of microsphere growth involving the sequential attachment of fragments and dust to already formed nuclei. During layering, the number of particles remains the same while the total mass of the system increases.
Order status tracking
Please inform me about the status of the order Rotary tablet press RZ-10A in El Paso ? 31/03/2025 08:30
Good afternoon, Jack. We have contacted the carrier, delivery is scheduled as agreed. Please let us know when you receive it. Thank you. 31/03/2025 08:30
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 31/03/2025 08:40
Good afternoon, Mia, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 31/03/2025 08:42
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Split, do you deliver to the terminal or to the actual address? 31/03/2025 08:50
Hello Evelyn, we deliver all over USA including to Split . The price in the catalog includes any delivery our customer asks for. 31/03/2025 08:50
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 31/03/2025 09:00
Good afternoon, Maya! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 31/03/2025 09:01
Mixer with paddle for powders CX-100 what is the exact packing size ? 31/03/2025 09:10
Olivia, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 31/03/2025 09:10
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 31/03/2025 09:20
Good afternoon, Jackson! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 31/03/2025 09:23
HX-6 Plastic Tube Filling and Sealing Machine in Oslo? Price delivery terms and conditions 31/03/2025 09:30
Jackson, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 31/03/2025 09:30
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 31/03/2025 09:40
Good afternoon, Alexander! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 31/03/2025 09:42
Good afternoon, I am hoping as stipulated in the contract to get the UNIC 600A Tablet Press in Lucca ! Please comment. 31/03/2025 09:50
Good day, Bella! Our manager has communicated with the delivery service, the equipment will be delivered to Lucca at your address. Please let us know when you receive it. 31/03/2025 09:54
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 31/03/2025 10:00
Hello Aiden, We are on time, between 16:00-18:00 a driver will contact you about unloading. 31/03/2025 10:00
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER