СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. Homogeneity of suppository is checked visually on a longitudinal slice for the presence or absence of inclusions, pieces” of the basis, particles of different colors, other inclusions, while the presence of air rod is allowed. Deviations in the mass of suppositories are allowed within 5%. Suppositories should have the correct uniform shape. In suppositories, the drug substances must be accurately dosed. The suppositories must have a hardness that makes them easy to use.

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Information updated: 09 / 07 / 2026
Available for
Production: 1 year на оборудование для производства суппозиториев в фармацевтической отрасли

Model: Standardization of suppositories in the pharmaceutical industry

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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.

Additional information

The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.

Order status tracking

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Layla
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 22/07/2026 03:18

Roman Tsibulsky
Hello Layla, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 22/07/2026 03:22

Lucas
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 22/07/2026 03:28

Roman Tsibulsky
Lucas, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Louisville 15 calendar days. 22/07/2026 03:29

Ruby
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Virginia Beach ( Europe) ? How much time for delivery ? 22/07/2026 03:38

Roman Tsibulsky
Ruby, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/07/2026 03:41

Henry
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Mariehamn, but immediately upon arrival send it to Tbilisi. 22/07/2026 03:48

Roman Tsibulsky
Hello Henry, we will try to resolve this issue for you. 22/07/2026 03:49

Sebastian
Good day, delivery time of semi-automatic drum filling machine DF-10 to Antwerp, will the courier call us? 22/07/2026 03:58

Roman Tsibulsky
Sebastian, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 22/07/2026 04:02

Hazel
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Houston. Thank you. 22/07/2026 04:08

Roman Tsibulsky
Hazel, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Houston is scheduled for in the interval from 10:00-12:00. Please notify us upon receipt. 22/07/2026 04:12

Zoey
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 22/07/2026 04:18

Roman Tsibulsky
Hello Zoey, Transportation has advised that in the interval from 10:00-12:00 driver will definitely deliver the box to your address. We apologize. 22/07/2026 04:21

James
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/07/2026 04:28

Roman Tsibulsky
James, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in New York ? Contact Natalia, she will send the contract and invoice. 22/07/2026 04:31

Henry
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/07/2026 04:38

Roman Tsibulsky
Henry, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Fresno ? Contact Natalia, she will send the contract and invoice. 22/07/2026 04:42

Samuel
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 17:30 to open the box and test. 22/07/2026 04:48

Roman Tsibulsky
Samuel, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/07/2026 04:48