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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.
Pharmaceutical Glossary
Technical specifications
All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.
Additional information
The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.
Order status tracking
Roman Tsibulsky +79853643808
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Layla
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 31/08/2026 07:27
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 31/08/2026 07:27
Roman Tsibulsky
Layla, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Stockton 15 calendar days. 31/08/2026 07:28
Layla, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Stockton 15 calendar days. 31/08/2026 07:28
Grace
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 31/08/2026 07:37
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 31/08/2026 07:37
Roman Tsibulsky
Grace, Checking delivery status. The shipment is already in Monte Carlo warehouse. Please arrange for pickup. 31/08/2026 07:38
Grace, Checking delivery status. The shipment is already in Monte Carlo warehouse. Please arrange for pickup. 31/08/2026 07:38
Benjamin
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Munich, do you deliver to the terminal or to the actual address? 31/08/2026 07:47
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Munich, do you deliver to the terminal or to the actual address? 31/08/2026 07:47
Roman Tsibulsky
Hello Benjamin, we ship all over Europe and the US including to Munich . The price in the catalog includes any delivery our customer asks for. 31/08/2026 07:50
Hello Benjamin, we ship all over Europe and the US including to Munich . The price in the catalog includes any delivery our customer asks for. 31/08/2026 07:50
Elizabeth
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 31/08/2026 07:57
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 31/08/2026 07:57
Roman Tsibulsky
Hello Elizabeth, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 31/08/2026 07:59
Hello Elizabeth, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 31/08/2026 07:59
Matthew
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 31/08/2026 08:07
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 31/08/2026 08:07
Roman Tsibulsky
Hello Matthew, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 31/08/2026 08:10
Hello Matthew, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 31/08/2026 08:10
Layla
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 31/08/2026 08:17
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 31/08/2026 08:17
Roman Tsibulsky
Hello Layla, Our manager Natalia after lunch will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Split in 15 days. 31/08/2026 08:19
Hello Layla, Our manager Natalia after lunch will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Split in 15 days. 31/08/2026 08:19
Dylan
Waiting for delivery to Perast of a TR-02 hard gelatin capsule polishing machine. What about it? 31/08/2026 08:27
Waiting for delivery to Perast of a TR-02 hard gelatin capsule polishing machine. What about it? 31/08/2026 08:27
Roman Tsibulsky
Hello Dylan, on your order we inform you that before lunch the driver will contact you to clarify the time and place of unloading. 31/08/2026 08:28
Hello Dylan, on your order we inform you that before lunch the driver will contact you to clarify the time and place of unloading. 31/08/2026 08:28
Savannah
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 31/08/2026 08:37
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 31/08/2026 08:37
Roman Tsibulsky
Good afternoon Savannah, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. In the afternoon we will get a reply from the manufacturer on the final time frame. 31/08/2026 08:39
Good afternoon Savannah, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. In the afternoon we will get a reply from the manufacturer on the final time frame. 31/08/2026 08:39
Benjamin
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 31/08/2026 08:47
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 31/08/2026 08:47
Roman Tsibulsky
Hello Benjamin, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 31/08/2026 08:49
Hello Benjamin, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 31/08/2026 08:49
Grace
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Albufeira, but immediately upon arrival send it to Bratislava. 31/08/2026 08:57
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Albufeira, but immediately upon arrival send it to Bratislava. 31/08/2026 08:57
Roman Tsibulsky
Hello Grace, we will try to resolve this issue for you. 31/08/2026 09:01
Hello Grace, we will try to resolve this issue for you. 31/08/2026 09:01
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- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
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- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
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- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
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- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
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- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS