СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Standardization of suppositories in the pharmaceutical industry

Standardization of suppositories in the pharmaceutical industry

All manufactured suppositories must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a homogeneous mass. Homogeneity of suppository is checked visually on a longitudinal slice for the presence or absence of inclusions, pieces” of the basis, particles of different colors, other inclusions, while the presence of air rod is allowed. Deviations in the mass of suppositories are allowed within 5%. Suppositories should have the correct uniform shape. In suppositories, the drug substances must be accurately dosed. The suppositories must have a hardness that makes them easy to use.

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Information updated: 28 / 04 / 2026
Available for
Production: 1 year на оборудование для производства суппозиториев в фармацевтической отрасли

Model: Standardization of suppositories in the pharmaceutical industry

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The release of drugs from hydrophobic bases is slower.
When making suppositories, it should be remembered that the drug substances introduced into the composition of these dosage forms in the form of aqueous solutions, absorbed much easier and faster have a local effect than the drug substances introduced in dry form. In terms of microbiological purity of preparations for rectal administration are classified by the State Pharmacopoeia to category IIIA, ie in 1 g or 1 ml of the drug should contain no more than 1000 aerobic bacteria and 100 fungi in the absence of Escherichia coli.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

All suppositories (especially rectal and urethral) must have sufficient hardness to overcome the resistance of tissues and sphincters, otherwise the suppositories are deformed and their use becomes impossible. The melting point determined for lipophilic suppositories should not exceed 37 °C. Moreover, it is necessary that their melting occurred in a short temperature range (1-2 ° C). If the definition of melting temperature causes difficulties, then set the time of full deformation, which should be no less than 3 and no more than 15 min. For suppositories made on hydrophilic bases, determine the time of dissolution in water, which should not exceed 1 h.

Additional information

The liquid mass formed after melting or dissolution of suppositories should spontaneously spread over the mucous membrane, forming a uniform layer. This condition is necessary to ensure close contact of the drug substance with tissues and its proper absorption. Suppositories should easily release the drug substances included in them. This quality depends both on the properties of the base used for the preparation of suppositories, and on the method of introduction of drugs into the base. Hydrophilic bases (except polyethylene oxides) easily release active substances, as they are able to dissolve in the secretions of mucous membranes.

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Alexander
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Liverpool, then I want to buy an automatic capsule machine model GN-28 02/05/2026 16:22

Roman Tsibulsky
Good afternoon, Alexander! On the first question - the shipment will arrive in Liverpool In the afternoon. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 02/05/2026 16:24

Olivia
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 02/05/2026 16:32

Roman Tsibulsky
Hello Olivia, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 02/05/2026 16:34

Logan
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 02/05/2026 16:42

Roman Tsibulsky
Logan, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer as stipulated in the contract. We will report back immediately. 02/05/2026 16:43

Sebastian
I've been calling your office since this morning, and no one's picking up the phone. 02/05/2026 16:52

Roman Tsibulsky
Good afternoon, Sebastian! The office will be open from 9:00 GMT. We'll be in touch. 02/05/2026 16:55

Riley
Good day, I want tomorrow until 15:30 to get FF-02 tablet and capsule filling machine in Porto? 02/05/2026 17:02

Roman Tsibulsky
Good afternoon, Riley! We have contacted the transportation company, your shipment is arriving in Porto without delay. Please wait for a call from a representative of Business Lines. 02/05/2026 17:05

Ava
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 02/05/2026 17:12

Roman Tsibulsky
Good afternoon, Ava, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 02/05/2026 17:12

Elijah
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 02/05/2026 17:22

Roman Tsibulsky
Good afternoon Elijah, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 15:30 we will get a reply from the manufacturer on the final time frame. 02/05/2026 17:24

Lily
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Monte Carlo, do you deliver to the terminal or to the actual address? 02/05/2026 17:32

Roman Tsibulsky
Hello Lily, we ship all over Europe and the US including to Monte Carlo . The price in the catalog includes any delivery our customer asks for. 02/05/2026 17:33

Samuel
Rotary tablet press RZK-25 I want to order with delivery to Berlin 02/05/2026 17:42

Roman Tsibulsky
Good day, Samuel We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 02/05/2026 17:44

Henry
Good afternoon, please confirm that tomorrow until 17:30 we will receive our shipment in Brussels? Contact the transportation company. 02/05/2026 17:52

Roman Tsibulsky
Hello Henry ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Brussels in a few days. Please expect it. 02/05/2026 17:54