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Microspheres pharmaceutical pellets

Pellet production technologies and equipment used


  • Production of quality pellets
  • Microcapsule Extension
  • Pellets production
  • Microcapsule Extension
Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Direct pelletizing involves the creation of pellets directly from a powder with a binder or solvent. This is a fairly quick process in which a small amount of excipients is required. In the initial stage, the powder is mixed and moistened. Then, if necessary, a solvent or a binder is added, which is sprayed onto the powder particles. A layer of powder is driven in a circular motion. Due to collisions and accelerations arising from this, agglomerates arise, which are rolled around to obtain dense pellets of the correct spherical shape. The rotational speed has a direct effect on the density and size of the pellets. Then, the wet pellets are dried in the fluidized bed. An advantage of the direct pelletizing process is the production of round pellets, ...

Layering Pelletizing


  • Pellets
  • Microspheres and pellets technology basics
  • Pellets
Microspheres can also be made by layering a drug substance on inert microspheres. The layering process is the sequential application of layers of a drug substance from a solution, suspension or dry powder to the core. Nuclei can be crystals or granules of the same material or inert particles. When layered from a solution or suspension, particles of the drug substance are dissolved or suspended in a liquid. When the powder is layered, complete dissolution does not occur due to the small amount of liquid, regardless of the solubility of the active component in the liquid. When powder applying the drug, the binder solution is first sprayed onto inert nuclei, and then the powder is applied. By adding a layer-forming component, layer-by-layer pellet formation is carried out to the desired value. Suitable layer-forming components are powder and binders, suspensions or solutions. Due to the movement of pellets in the rotor, the application of dense layers.

Pharmaceutical Pelletizing


  • pelletizing
To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of formation and growth of granules. Some theories have been derived from experimental data, others have been derived from visual observations. Conventional granulation as the most fully studied and classified process of microsphere formation, carried out using different equipment, was divided into three successive stages: the nucleation stage, the transition stage and the sphere growth stage. However, based on experiments to study the formation and growth mechanism of microspheres, the following microsphere growth mechanisms were proposed: core formation, bonding, layering, and friction material transfer.

Microspheres and pellets technology basics


  • Pellet making
  • Pellets pharmaceutical production
  • Gelatin capsules in blister pack
  • Microspheres pharmaceutical pellets
Microspheres (pellets) - a new type of solid dosage form. Recently, in the pharmaceutical industry, drug manufacturers have been producing microspheres, or pellets (from the English pellet - pellet, pellet, pellet), as the final or intermediate type of dosage form for the manufacture of finished dosage forms. The microspheres are increasingly used in the production of finished drugs, as they have a number of significant and undeniable advantages. Pellets can be tabletted with the addition of suitable excipients, they can be the contents of the capsules, as well as part of the suspensions. Microspheres (pellets) are agglomerates of finely divided powders or granules, which, in turn, can consist of medicinal and auxiliary substances. Microspheres are small, spherical or hemispherical solid particles with a diameter of 0.5 to 1.5 mm, having good flowability, intended for oral administration. Microspheres can be made ...