Of the soft drugs for external use, ointments are most often used, which consist of an ointment base and a drug substance evenly distributed in it. Ointments are soft drugs for topical use, the dispersion medium of which at the set storage temperature has a non-Newtonian type of flow and high values of rheological parameters. They are highly viscous liquids capable of forming ...
Ointments contain medicinal and auxiliary substances that must be evenly distributed in the dosage form. Excipients form a simple or complex basis. Thus, the ointment base is a carrier of a drug. Depending on the composition, it may affect the release, bioavailability and therapeutic effect of the drug substance. The basics provide the necessary mass of ointment, the proper concentration of medicinal substances, soft ...
Terms and conditions of storage of ointments are due to technical documentation. Factory-made ointments are stored in a cool, dark place from six months to two years or more. The storage conditions of ointments should be strictly observed. Environmental factors, especially temperature changes and light, often adversely affect the quality of ointments.
The manufacturing process of ointments is periodic or continuous. The periodic process can be one-, two-, three-stage, etc. depending on the number of devices in which separate stages of the process for producing ointments are successively carried out. The technology for the production of ointments at pharmaceutical enterprises is carried out in accordance with the regulations. It includes the following stages: sanitization of premises and equipment; preparation of raw materials (medicinal ...
On-site control of ointments is carried out at almost every stage of production and especially before the preparation of the drug. The final conclusion on all quality indicators of the finished product is given by the quality control department of the plant. In industrial production, the test is carried out in accordance with the requirements of the general article of the State Pharmacopoeia (GF) for ointments, as well as the requirements included in the GF articles for individual names of ointments ....
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