PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Preparation and filling of gelatin capsules

7711

6479816

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The calculated amount of purified water is poured into the container, which is heated to a temperature of + 65 ° C in a gelatin mass preparation apparatus, and a stirrer is turned on. Then glycerin is poured with nipagin and gelatin is filled in. The gelatin mass is mixed for 1.5 hours until the gelatin is completely dissolved, then, with the agitator turned off, it settles for 0.5—1.5 hours. After that, the gelatin mass is filtered through a sieve and its viscosity is measured using a viscometer. If the viscosity indicators do not correspond to the norm, the ratio of water and gelatin is recalculated. The filler solution is prepared according to the technological instructions. The prepared gelatin mass and filler in the required...

Film coatings of tablets

7749

6480190

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A film coating is a thin shell formed on the surface of a microsphere (pellets). Tablets or granules after drying of the film-forming substance solution applied to their surface. The thickness of the film coating layer is approximately from 5 to 50 microns. The droplets of the coating liquid are sprayed onto the initial particles. The supplied process air evaporates the liquid and dries the film layer on the surface of the particles. The small droplet size and low viscosity ensure uniform distribution of the film on the particle surface. An important point when applying the coating is a very uniform application of the coating material. The coatings must be dense, without mechanical damage and cracks. Film coating is an effective way of applying protective...

Rotary tableting machines

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6481541

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Rotary tablet machines (RTM), unlike eccentric ones, have a large number of matrices and punches. The matrices are mounted in a rotating matrix table. The pressure in the RTM increases gradually, which ensures a soft and uniform pressing of the tablets. rTMS have high productivity (up to 0.5 million tablets per hour). The technological cycle of tableting on RTM consists of a number of sequential operations: Filling the matrices with tableted material (volumetric dosing method). Actually pressing. Ejection. Dropping pills. The operations are performed sequentially in automatic mode. The upper and lower punches slide along the guides (caps) and pass between the pressing rollers, exerting simultaneous pressure on them. The pressure increases and decreases gradually, which leads to uniform and soft pressing of the tablet…

Basic requirements of gmp soft dosage forms

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6480973

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In the production of ointments, creams and other soft dosage forms, there is a particularly high risk of microbial and other contamination. Therefore, special measures are needed to prevent any contamination. Soft dosage forms have specific rheological properties and in most cases are heterogeneous dispersed systems. Therefore, in order to avoid heterogeneity of the product due to uneven distribution of components, formation of gas emulsions and destabilization of dispersed systems, special attention should be paid to the proper conduct of the technological process, the equipment used and the temperature conditions of product storage. Requirements for production facilities and equipment. The environment of the premises, taking into account all measures to protect production, should pose a minimal risk in terms of contamination of materials and products.

Powder screening in production

7882

6481523

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When grinding solid materials on the equipment discussed earlier, a homogeneous product is practically not obtained, Therefore, such an operation as sieving is necessary to separate larger particles. Sieving is an integral part of grinding to obtain a mixture with a certain granulometric composition. Sieving eliminates soft conglomerates of powders by rubbing them through perforated plates or sieves with a certain size of holes. Sieving, or screening, is the process of separating a mixture of grains of various sizes using sieves into two (or more) groups. The size of the grains passing through the sieve cells is characterized by a number. There are 16 different sieves, which correspond to 7 degrees of grinding.

Preparation of suppository base

7863

6481336

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The stage of preparation of the suppository base begins with the weighing of its components. In the first stainless steel reactor with a steam jacket, paraffin is melted, in the second reactor, hydrofluid is melted by supplying steam to the steam jacket. The heated hydrofluid is pumped into a reactor with pre-melted paraffin. The mixture is heated to a temperature of 60-70 °With and add cocoa butter. In order to avoid changing the modification of cocoa butter, the heating should not exceed 70 ° C and be prolonged. After the base is completely melted, it is stirred for 40 minutes using a stirrer. In the finished base, the melting point and the time of complete deformation are determined.

Industrial production of suppositories

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6481353

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There are several methods of making suppositories, among them: rolling out, pressing and pouring the molten mass into molds. The rolling out method is often used in pharmacy practice. This method is labor-intensive, low-hygienic, and the resulting suppositories differ slightly in appearance. Waxed capsules are used as packaging for suppositories. The pressing method makes it possible to produce suppositories like tablets in eccentric (crank) tablet machines using matrices and punches of the appropriate shape. The production of such suppositories is based on the transformation of fat suppository masses into powder form, which allows it to pour out freely from the loading funnel. To achieve the accuracy of dosing and the necessary flowability, the suppository mass is cooled in the refrigerator to a temperature of 3-5...

Direct pressing of powders in production

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6481361

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Direct pressing is the process of pressing non—granulated powders. From the technological scheme for obtaining tablets, it can be seen that direct pressing allows you to exclude 3-4 technological operations from the production process. The direct pressing method has a number of advantages, including: reduction of the production cycle time due to the abolition of a number of operations and stages; use of less equipment; reduction of production areas; reduction of energy and labor costs; production of tablets from moisture-, thermolabile materials and incompatible substances. The disadvantages of the direct pressing method include: the possibility of delamination of the tablet mass; changing the dosage when pressing with a small amount of active substances; the need to use high pressure. Some of these disadvantages are minimized...

Polymerization and polycondensation

7907

6481768

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When microencapsulating solid particles by polymerization and polycondensation methods, a polymerization initiator is pre-grafted onto the surface of the encapsulated substance.

Pelletizing in pharmaceutical production

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6481388

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To study the formation of pellets (microspheres), it is necessary to understand the mechanisms of formation and growth of granules. Some theories were derived from experimental data, others were derived from visual observations. Conventional granulation as the most fully studied and classified process of formation of microspheres, carried out using different equipment, was divided into three successive stages: the stage of core formation, the transitional stage and the stage of sphere growth. However, based on experiments to study the mechanism of formation and growth of microspheres, the following mechanisms of microspheres growth have been proposed: core formation, joining, layering and transfer of material by friction.