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If, for example, the tablets are ejected with a damaged or uneven surface, this indicates that the mass is strongly adherent or lacks sliding agents, or that the pressing surfaces are not smooth enough. If the tablet has edges, the diameter of the punches used is small. If the tablet surface is bumped, the bottom punch is not raised high enough and its position must be adjusted.
If the tablets disintegrate when ejected, the pressing pressure should be increased or more binders should be added. If the tablets break up, the pressure is too high or the granulate is too dry. The tabletting process may produce tablets with the following defects, such as: Insufficient mechanical strength – observed with insignificant press pressure, insufficient concentration of binder, adhesive and lubricant, and low plasticity of substances. Poor quality coating of tablets. It can be avoided by adding microcrystalline cellulose to the coating, which improves the plasticity of the coating. Adhesion. When the particles of the tablet mass have a higher adhesion to the punch than to each other, adhesion of the particles to the tool occurs. Adhesion at high stock moisture levels to the top punch can cause failure of the apparatus. High stock moisture and insufficient amounts of opening agents also lead to sticking. Excessive rubbing. Excessive kneading of the mass can cause the matrix parts to stick together. Reduction in tablet weight and formation of a non-glossy surface occurs. Reduced shelf life – may occur as a result of the use of inaccurate amounts of loosening, binding, moistening auxiliaries, insufficient pressure, which ultimately leads to incomplete action of the active substance. Inaccurate dosage. If the tablet mass has insufficient flowability, the matrix is filled unevenly. This can be avoided by optimizing the particle size or by adding an excipient such as aerosil. Therefore, to avoid defects in the tabletting process, the optimum parameters should be selected on a case-by-case basis.
Pharmaceutical Glossary
Technical specifications
During the loading operation, the top slider roller with punch is at the highest point of the upper caper (stage I). It then slides down the sloping kapir. The punch touches the matrix hole, plunges into it and compresses the material. The pressure builds up and reaches its maximum at the moment when the slider roller is under the pressure of the roll (pressing operation – stage II). After that, the roller with the punch starts to climb up the capir and reaches the maximum. The lower slider makes the following movements: in the loading stage, its roller is supported by the roller that regulates the volume of the matrix hole. The lower slider moves along the straight capir. During the pressing operation, its roller is lifted by the pressing roller, so that the lower punch exerts pressure on the tablet material from its side. The capir then moves slightly upward, causing the lower punch to push the tablet out (ejection operation – stage III).
After that, due to the lowering of the capir, the lower punch also goes downwards and everything is repeated again. Below is a description of the features of domestic rotary tablet machines. In general, RTMs can have from 12 to 55 dies (positions) in the rotor. Besides, they can be single-flow (with one feeding hopper) and double-flow (with two feeding hoppers). In the latter case, the entire production process is completed in half a rotation of the rotor and, as a result, the productivity of the PTM is dramatically increased. Such a high-performance machine is, in particular, RTM-41, which is a dual-flow machine with 41 pairs of press tools. This machine allows to produce tablets of 5-15 mm and 20 mm diameter. The RTM-300M machine is used to produce cylindrical-shaped tablets of small diameters with flat and spherical ends. Since in RTM the pressure is bilateral and increases (is removed) gradually, tablets are of high quality. These machines work evenly and do not dust. An agitator can be installed in the feed hopper. The rotating rotor allows the installation of devices for powdering the matrix hole before loading, as well as after it (to pollinate the surface of the filled matrix). Some designs have brush wiping or cleaning devices to keep the punches clean. Rotary press-automatic machines are produced, equipped with a vibrating feeder, which can, by adjusting the amplitude and frequency of vibrations of the vibrating, filling part of the feeder, break the forces of adhesion between powder particles, thus significantly increasing its mobility and compensating for the lack of bulkiness.
Additional information
The productivity of automatic machines equipped with a vibrating feeder is increased. In this case, granulation is also required, but with slightly reduced requirements for granulate homogeneity. In domestic tablet presses, the tablet mass and possible mechanical inclusions are controlled during the tabletting process. For mass control there are automatic devices – in case of deviation of tablet mass from the preset one a signal lamp is switched on. Automatic control for metal inclusions is performed with the help of a device that detects and removes tablets with metal inclusions from the’flow. To remove from the surface of tablets coming out of the press, dust fractions are used dedusters. Tablets pass through a rotating perforated drum and are cleaned of dust, which is sucked out of the dedusters by special devices. Tableting of drugs usually occurs at pressures of 25-250 mPa; higher pressures are rarely used. Table 4.8 gives an example of the main technical parameters of rotary tabletting machines. Although RTMs are technically far superior to eccentric machines, they have some disadvantages, namely: complex construction; require more spare punches and dies. The quality of tablets is influenced by the amount of pressure, pressing speed, condition and wear resistance of the press tool, which is subjected to quite a lot of wear and tear, as it experiences heavy loads. The durability of dies is 2-3 times less than that of punches, which is explained by chemical interaction of the matrix material with the tablet mass, rigid loading of the matrix, friction of particles of the pressed material and the tablet against the walls of the matrix;
more difficult preparation for pressing; more labor-intensive cleaning; large variation in mass deviation from the nominal value due to the use of dozens of sets of press tools. Eccentric machines use only one set of press tools and therefore the variation in the mass of individual tablets is less than when pressing on RTM. Based on the above disadvantages it can be concluded that rotary tablet machines are cost-effective only for mass production. Before pressing, any tablet machine must be set up, calibrated and adjusted optimally. Before starting the process, a test tabletting process is carried out by starting the machine manually, which results in the required tablet weight, proper strength and disintegration as well as the elimination of external imperfections.
Order status tracking
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Tartu, but immediately upon arrival send it to Cinque Terre. 08/05/2024 07:36
Hello James, we will try to resolve this issue for you. 08/05/2024 07:38
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Albufeira, but immediately upon arrival send it to Paris. 08/05/2024 07:46
Hello Savannah, we will try to resolve this issue for you. 08/05/2024 07:46
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Sofia, do you deliver to the terminal or to the actual address? 08/05/2024 07:56
Hello James, we ship all over Europe and the US including to Sofia . The price in the catalog includes any delivery our customer asks for. 08/05/2024 07:59
Tell me the NJ-120 automatic capsule machine went ? 08/05/2024 08:06
Henry, good afternoon. Yes, already closer to evening you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 08/05/2024 08:08
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 08/05/2024 08:16
Hello Alexander, Transportation has advised that as agreed driver will definitely deliver the box to your address. We apologize. 08/05/2024 08:20
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 08/05/2024 08:26
Hello James, Our manager Natalya as agreed will dial the driver, also we ask you yourself to the transportation company. 08/05/2024 08:29
HX-6 Plastic Tube Filling and Sealing Machine in Athens? Price delivery terms and conditions 08/05/2024 08:36
Gabriel, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 08/05/2024 08:39
We're from New Jersey, we paid for the equipment on your invoice yesterday. Has the payment been received? How long will it take to deliver to us? 08/05/2024 08:46
Harper, hello. Payment is credited to our settlement account. Term of manufacture of your equipment by the factory 20 working days, delivery from the factory to our warehouse in the USA 1 month, delivery from the warehouse in Indianapolis 15 calendar days. 08/05/2024 08:47
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Dubrovnik, do you deliver to the terminal or to the actual address? 08/05/2024 08:56
Hello Scarlett, we ship all over Europe and the US including to Dubrovnik . The price in the catalog includes any delivery our customer asks for. 08/05/2024 08:57
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 08/05/2024 09:06
Hello Lily, Our manager Natalia in the interval from 10:00-12:00 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Butrint in 15 days. 08/05/2024 09:09
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- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
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- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
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