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Binders for wet granulation

6232

980069
  • Granulation of tablet materials
  • Granulation process in the production of tablets
  • Granulation in the manufacture of tablets
  • Tablet compression
  • Granulation of tablet materials
  • Granulation process in the production of tablets
  • Granulation in the manufacture of tablets
  • Tablet compression

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Detailed Description of Wet Granulation

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Binders for wet granulation

There are some requirements for granulating liquid, one of which is that the granulating liquid should not dissolve the active substance. As the granulating liquid, water, an aqueous solution of ethanol, acetone and methylene chloride can be used. As a binding agent for wet granulation in modern pharmaceutical production, a wide range of substances is used, for example: starch (5-15% g / g), starch derivatives, cellulose derivatives that improve the ductility of granules, as well as gelatin (1-3% g / g) and PVP (3-10% g / g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidone (PVP), various brands of which (Collidon 25, 30 and 90F) are widely available on the market.

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  • Updated: 08/10/2019
  • Pharmaceutical equipment in stock and on order
  • Warranty: 1 year for wet granulation equipment

Model: Wet granulation

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Popular Searches

15%

Testimonials from real people about wet granulation equipment

15%

Reviews from the owners about the operation of equipment for wet granulation

35%

Detailed Description of Wet Granulation

35%

Where to find a wet granulation specialist in Kazakhstan?

What is included in the price

  1. Phased expert assessment your problem and a detailed discussion of solutions in 24 hours.
  2. Company selection manufacturer and conversation with the selected supplier.
  3. Selection, optimal for the client, payment scheme and delivery time.
  4. Receiving and checking equipment before sending with a video report.
  5. Consultation from our specialist with 17 years of experience  throughout the life of the equipment.

If you did not find the necessary equipment in our catalog, then call +74953643808 and we will certainly offer you what you were looking for, or we will pick up similar equipment that is suitable not only for technical characteristics, but also for price.
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Plasdon polymers have excellent adhesion, good film-forming properties, surface-active properties and high solubility in water and many pharmaceutical solvents. Due to this combination of properties, these polymers are widely used in a number of drugs. Plasdon polymers have long been used as binders in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet bonding agent for direct compression and dry granulation, as well as a wet granulation bonding agent.

Specifications

The granules obtained with PVP are hard, easy-flowing granules to form harder tablets with low brittleness. The PVP polymer improves the solubility of the active substance by complexing. In addition, PVP acts as a crystallization inhibitor. The patterns below are identified by the BASF Fine Chemicals Division. They are examined by the example of Collidon. Wet granulation using Kollidon 25, Kollidon 30 and Kollidon 90F usually results in a harder granular material with better flow properties than with other binders with less abrasion and higher bonding strength. The content of the polymer used in the granulating liquid may vary within the range of: Kollidon 25 - 2-5%; Collidone 30 - 2-5%; Kollidon 90F- 1-3%.

Tips for our customers

Thus, BASF research has shown that when using Collidone 90F, tablet hardness is greatest at the same compression pressure. All binders were used in an amount of 3%. On the basis of the data presented, it can be concluded that calcium phosphate tablets have increased hardness and reduced fragility when used as a binder in the wet granulation process of Collidone 30. In addition to Collidon, there are a large number of substances used in the pharmaceutical industry as binders. Consider two of them. Plasdon FPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

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