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Catalog / Pharmaceutical Technology / Tablet technology / The force of ejection of tablets from the matrix

The force of ejection of tablets from the matrix

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  • Production of chlorine tablets
  • Effervescent tablet manufacturing
  • Stage production of tablets
  • India production pills
  • Production of chlorine tablets
  • Effervescent tablet manufacturing
  • Stage production of tablets
  • India production pills

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Catalog / Pharmaceutical Technology / Tablet technology / The force of ejection of tablets from the matrix

The force of ejection of tablets from the matrix

To eject a pressed tablet from the matrix, it is necessary to expend force to overcome friction and adhesion between the side surface of the tablet and the matrix wall. Taking into account the magnitude of the ejection force, additives of antifriction (sliding or lubricating) substances are predicted. As an example, the results of determining the technological characteristics of rounded substances are given. Powders with round-shaped particles with a main particle size of more than 100 microns (ranitidine g / hl, carbamazepine, phenazepam) have high (8–9 g / s) flowability, high bulk density before and after compaction, but low compressibility and a small compaction coefficient.
Phenazepam has a slightly lower flowability value (8 g / s), probably because it contains more fine fractions and does not contain particles larger than 250 microns, which are present in ranitidine and carbamazepine.

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  • Updated: 08/10/2019
  • Pharmaceutical equipment in stock and on order
  • Warranty: 1 year on equipment for ejecting the pressed tablet from the matrix

Model: The force of ejection of tablets from the matrix

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The image of the topography of the surface of the object is visually observed on the screen of the monitor and recorded on wide-format film. The principle of operation of an electron scanning microscope is as follows: a narrow beam of electrons with a kinetic energy of the order of 1–25 kV enters the sample under study. Electrons of the reflected beam (secondary electrons) released by atoms located on the surface form an image recorded on the screen or microphotographs. In order to avoid damage to the sample or its combustion, the sample is preliminarily coated with a conductive layer (usually a thin layer of gold), which prevents surface charging. The method of electron scanning microscopy allows high-resolution determination of the structure of the studied samples, the shape and size of particles, pore size, pore size distribution, surface porosity and visualize pore geometry.

Specifications

This once again proves the fact that the finer the particles, the lower the flowability.
The technological characteristics described above of powdered drug substances are of paramount importance in the development of the composition and technology of tablet forms, which should provide the necessary bioavailability and, accordingly, the effectiveness and safety of the drug.
The technological characteristics of the powders are established quickly enough, the methods for their determination are simple and not difficult, therefore, these methods are currently widely used in the pharmaceutical industry to carry out mass control of all medicinal substances entering the production.

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Typically, in pharmaceutical enterprises, dispersion analysis of drug substances is carried out using such available methods as sieve analysis, microscopy, using a laser particle analyzer, etc. This allows even at the stage of selection of firms supplying pharmaceutical substances to exclude non-standard substances from entering the developed technological process and to ensure the high quality of domestic tablet preparations. To determine properties such as surface, shape and particle size, the method of electron scanning microscopy can be used. Stationary electron scanning microscope designed to study the topography (microgeometry) of a solid surface by the method of secondary electron emission.

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