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Catalog / Pharmaceutical Technology / Creams and ointments production equipment / Classification of ointments by the type of dispersed systems

Classification of ointments by the type of dispersed systems

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  • Ointment Production
  • Equipment for the production of ointments and pastes
  • The introduction of drugs into the ointment base
  • Ointment Production Line
  • Ointment Production
  • Equipment for the production of ointments and pastes
  • The introduction of drugs into the ointment base
  • Ointment Production Line

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Catalog / Pharmaceutical Technology / Creams and ointments production equipment / Classification of ointments by the type of dispersed systems

Classification of ointments by the type of dispersed systems

From the point of view of technology (production cycle), as well as the physicochemical nature of the basis and nature of the distribution of medicinal substances in the base, the classification of ointments according to the type of dispersed systems is of the greatest importance. According to this classification, homogeneous and heterogeneous ointments are distinguished. Homogeneous ointments are characterized by the absence of an interface between the medicinal substances and the base. In such ointments, medicinal substances are distributed in the base according to the type of solution, i.e. reduced to molecular or micellar dispersion. Depending on the method of preparation, these can be: ointments-alloys, which are a combination of several fusible, mutually soluble components; ointments solutions that contain medicinal substances dissolved in the base; extraction ointments obtained by extraction (extraction) of various plant or animal materials with a molten ointment base or vegetable oil.

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  • Updated: 08/10/2019
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Model: Classification of ointments

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Since solutions are not miscible with fatty bases, the resulting ointments are emulsions in which the dispersed medium is usually an ointment base. The composition of most ointments-emulsions includes emulsifiers, by virtue of which the ointments are quite fine and stable. However, there are ointments that are stable only due to the high viscosity of the dispersion medium. In such ointments, the dispersed phase consists of large droplets. Combined (suspension-emulsion) ointments are the most complex multicomponent systems, including both medicinal substances soluble in the ointment base, insoluble powdery ingredients and aqueous solutions of medicinal substances, i.e. systems in which several substances with different physicochemical properties are simultaneously present.

Specifications

Heterogeneous ointments are characterized by the presence of an interphase interface between medicinal substances and the base. Heterogeneous ointments are biphasic or multiphase systems. Depending on the nature of the distribution of medicinal substances, heterogeneous ointments are divided into suspension (trituration), emulsion and combined (suspension-emulsion) ointments. Suspension (trituration) ointments are systems containing solid powdered medicinal substances, insoluble in the ointment base and distributed in it as suspensions. The composition of ointments-suspensions include medicinal substances insoluble in water and fats.

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In the form of suspensions, medicinal substances are also introduced that dissolve in water, but their solutions are caustic and can cause skin irritation and necrotic phenomena (resorcinol, pyrogallol, zinc sulfate, mercury dichloride, Rochelle salt "). In a suspended state, substances are also introduced into the ointment that require a significant amount of water (borax, boric acid) for their dissolution. Ointment suspensions may contain one or more medicinal substances, each of which has its own interphase boundary. Thus, suspension ointments are two-, three- and multiphase systems. Emulsion ointments are characterized by the presence of a liquid dispersed phase, insoluble in the ointment base and distributed in it as an emulsion.

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