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The finished concentrate is pumped (through a hose with a kapron sieve) to a reactor with a suppository base. Preparation of suppository mass is carried out with constant stirring and heating to a temperature of 45-50 ° C. At the end of the process, the product is analyzed for homogeneity of the mixing of the components, the time of complete deformation, as well as the pour point and melting point of the mass are checked. Upon receipt of positive results, the suppository mass is fed to pouring into molds.
Specifications
At the stage of preparation of medicinal substances, water-soluble components are dissolved in water heated to 45 ° C, and fat-soluble components are dissolved in parts of the molten fat base. The resulting concentrates are filtered and then mixed with the rest of the base. Substances insoluble in water and base are introduced in suspension as follows: pre-ground medicinal substances are mixed in the reactor with an equal or one-and-a-half amount of base, heated to a temperature of 40-50 ° C.
Tips for our customers
The resulting concentrate is cooled and ground in colloidal mills. For the treatment of thermolabile substances, three-roll maser tubes are used. In addition, to obtain high-quality suspensions can be used rotary pulsation apparatus, rotary gear pumps and other equipment. To obtain the required degree of dispersion of the drug substance, introduced into the base as a suspension, the grinding time of the concentrate lasts from 2 to 4 hours
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- Logo Tablet Pill
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