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Catalog / Pharmaceutical Technology / Production of suppositories in production / Introduction to the suppository base of drugs

Introduction to the suppository base of drugs

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  • Production of suppositories in industrial production
  • Technological scheme for the production of suppositories
  • Suppository drug
  • Suppository composition
  • Production of suppositories in industrial production
  • Technological scheme for the production of suppositories
  • Suppository drug
  • Suppository composition

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Catalog / Pharmaceutical Technology / Production of suppositories in production / Introduction to the suppository base of drugs

Introduction to the suppository base of drugs

There are three ways of introducing drugs into a suppository base, which are determined by the physicochemical properties of the components: All water-soluble components are administered in the form of aqueous solutions; fat-soluble substances are administered in the form of fatty solutions; substances insoluble in water and fats are administered in the form of suspensions of powders triturated in bases. The resulting solutions or suspensions are called concentrates.

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  • Updated: 08/10/2019
  • Pharmaceutical equipment in stock and on order
  • Warranty: 1 year for equipment for introduction into the suppository base of medicinal substances

Model: Suppository base

  • Marked as: Melting analyzer Business Business plan The blog Investments Innovation Equipment catalog Commerce Company Buy a business Medication Medicinal substances New Preparation of suppository base Production Suppository Production Startup Articles Suppository line Suppository base Suppository Foundation Requirements Pharmaceutical equipment Suppository molding

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The finished concentrate is pumped (through a hose with a kapron sieve) to a reactor with a suppository base. Preparation of suppository mass is carried out with constant stirring and heating to a temperature of 45-50 ° C. At the end of the process, the product is analyzed for homogeneity of the mixing of the components, the time of complete deformation, as well as the pour point and melting point of the mass are checked. Upon receipt of positive results, the suppository mass is fed to pouring into molds.

Specifications

At the stage of preparation of medicinal substances, water-soluble components are dissolved in water heated to 45 ° C, and fat-soluble components are dissolved in parts of the molten fat base. The resulting concentrates are filtered and then mixed with the rest of the base. Substances insoluble in water and base are introduced in suspension as follows: pre-ground medicinal substances are mixed in the reactor with an equal or one-and-a-half amount of base, heated to a temperature of 40-50 ° C.

Tips for our customers

The resulting concentrate is cooled and ground in colloidal mills. For the treatment of thermolabile substances, three-roll maser tubes are used. In addition, to obtain high-quality suspensions can be used rotary pulsation apparatus, rotary gear pumps and other equipment. To obtain the required degree of dispersion of the drug substance, introduced into the base as a suspension, the grinding time of the concentrate lasts from 2 to 4 hours

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