Dosing (packing) of powders is carried out using special dispensers, mainly screw and vacuum, working according to the volume principle. Volumetric dispensers are simple to use, simple to operate, and provide up to 300 doses per minute. With a decrease in the dose of the drug and an increase in the rate of dosing, the error increases. Use special dispensers designed for volumetric dosing of bulk medicinal substances in doses from ...
The shape and size of the particles. Pharmaceutical substances are polydisperse powders, have a complex shape and, as a rule, significant roughness. Powdered drug substances (substances) are systems having particles of various shapes and sizes. In many medicinal substances, the particles are anisodiametric (asymmetric, uniaxial). They can be elongated (sticks, needles) or lamellar (plates, flakes, leaflets). A smaller proportion of powdered substances has ...
The technological properties of powdered medicinal substances depend on their physicochemical properties. Fractional (granulometric) composition is the size distribution of powder particles. The fractional composition has a certain effect on the degree of flowability, therefore, on the rhythmic operation of tablet machines, on the stability of the mass of the obtained tablets, the accuracy of the dosage of drugs, on the qualitative characteristics of the tablets (appearance, disintegration, strength, etc.). Studies of the fractional composition of pharmaceutical ...
Drying is the process of removing moisture from materials using energy to evaporate moisture and from the vapors of the resulting vapors. Among the various technological processes of pharmaceutical production, drying is one of the most significant operations both at the initial and final stages of obtaining pharmaceutical products. The drying process is necessary primarily to remove moisture from the material and bring it ...
Powders are packaged in the following materials. Paper capsules. For their manufacture are used: glued paper is a pulp with a glued layer of animal glue. Such paper is mainly used for packaging hygroscopic and non-volatile powders; Waxed and paraffin paper is a glued paper impregnated with wax or paraffin. Since it does not pass moisture and gases, it is used ...
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