Direct compression is the process of pressing granular powders. From the technological scheme for producing tablets, it can be seen that direct pressing eliminates 3-4 technological operations from the production process. The direct pressing method has several advantages, these include: reducing the time of the production cycle by eliminating a number of operations and stages; use less equipment; reduction of floor space; reduction of energy and ...
At present, automatic machines are widely used in industry for pouring suppositories, which produce suppositories in blister packs. This package is intended for packaging suppository mass in contour cells with subsequent sealing, encoding and cutting into strips of the required length. In medium-sized enterprises, suppository machines use a preformed tape, since the molding unit is sufficient ...
From the physicochemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium represented by the basis of the Dispersed phase, in the role of which are medicinal substances. Depending on the properties of drugs, dispersed suppository systems can be either homogeneous or heterogeneous. Homogeneous systems are formed in those cases when the drug substance is dissolved in the base. Heterogeneous systems are formed in ...
All suppositories produced must meet the requirements of the State Pharmacopoeia XI: Suppositories must have a uniform mass. The homogeneity of the suppository is checked visually on a longitudinal section by the presence or absence of inclusions, pieces of the base, particles of various colors, other inclusions; in this case, the presence of an air rod is permissible. Deviations in the mass of suppositories are allowed within 5%. Suppositories must have the correct same ...
There are several methods for manufacturing suppositories, among them: rolling out, pressing and pouring molten mass into molds. The rolling method is often used in pharmacy practice. This method is time-consuming, low-hygienic, and the resulting suppositories are slightly different in appearance. As packaging for suppositories, waxed capsules are used. The pressing method allows the production of suppositories like tablets in eccentric (crank) tablet machines using ...
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