OINTMENT PRODUCTION

Ointments, requirements for ointments and their classification

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6877789

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Of soft medicines for external use, ointments are most often used, which consist of an ointment base and a medicinal substance evenly distributed in it. Ointments are soft medicines for topical use, the dispersion medium of which, at a set storage temperature, has a non—Newtonian type of flow and high values of rheological parameters. They are highly viscous liquids capable of forming a smooth continuous film on the surface of the skin or mucous membrane. Ointments are the official dosage form intended for application to the skin, wound or mucous membranes. Despite the fact that ointments belong to the oldest medicinal forms mentioned in the Ebers papyrus, the works of Hippocrates, Galen and Avicenna, they have not lost their significance today, in modern medicine.

Classification of ointment bases

7911

6877786

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Ointments contain medicinal and auxiliary substances that should be evenly distributed in the dosage form. Excipients form a simple or complex base. Thus, the ointment base is the carrier of the medicinal substance. Depending on the composition, it can have an effect on the release, bioavailability and therapeutic effect of the medicinal substance. The bases provide the necessary mass of ointment, proper concentration of medicinal substances, soft consistency and have a significant impact on the stability of ointments. The degree of release of medicinal substances from ointments, the speed and completeness of their resorption largely depend on the nature and properties of the base. For example, an ointment of 2% boric acid on a consistent emulsion basis exhibits the same therapeutic activity as a similar...

Diphilic bases

7941

6878088

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Diphilic bases have a soft consistency and are easily distributed over the surface of the skin and mucous membranes. Diphilic bases are divided into two groups - absorption and emulsion. Absorption bases are hydrophobic. These are anhydrous compositions of hydrophobic bases with an emulsifier (surfactant), which have the ability to incorporate the aqueous phase to form an emulsion system of the water—oil type. Their composition most often includes mixtures of petroleum jelly, petroleum jelly oil, ceresine and other hydrocarbons with emulsifiers. Surfactants, which are part of the absorption bases, usually contribute to enhancing the therapeutic activity of ointments. Absorption Diphilic bases can be divided into two groups: Diphilic bases consisting of hydrocarbons and emulsifiers (surfactants) of the water—oil type (vaseline and lanolin or wool wax...

Incorporation of medicine substances into the ointment base

7872

6877405

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The next stage in the production of ointments is the introduction of medicinal substances into the ointment base. At the same time, it is necessary to pay attention to the following factors: the degree of dispersion of medicinal substances; their uniform distribution over the entire mass of the base; the method of administration of medicinal substances into the base; time, speed and order of mixing of components; temperature regime, etc. Medicinal substances are injected into ointments taking into account their quantity and physico-chemical properties. They come in three types: soluble in the base; easily soluble in water; insoluble neither in the base nor in water.

Vacuum production unit for liquid and paste products

7941

6878089

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The German-Swiss company FrymaKoruma, part of the Romaco group of companies, is well known in the world market of pharmaceutical equipment. In Russia, the equipment of this company is also widely represented at many enterprises. In particular, at one of the leading Russian pharmaceutical enterprises JSC Akrikhin, the production of ointments and creams is carried out at the Disho installation of FrymaKoruma. Vacuum is a production plant for liquid and pasty products FrymaKoruma MaxxD, which has the same principle of operation as the Disho installation, but is a more modern development of the company. FrymaKoruma MaxxD is a modular system for the production of emulsions and suspensions with a wide range of viscosity. The main advantages of the plant are high production efficiency, reduced operating...

Hydrophobic bases

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6878087

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Hydrophobic, or lipophilic, bases are chemically heterogeneous substances and their mixtures with pronounced hydrophobicity. This group includes: fat bases; hydrocarbon bases; silicone bases. Fat bases include animal, vegetable and hydrogenated fats, as well as waxes. Animal fats by chemical nature are triglycerides of higher fatty acids. By their properties, they are close to the fatty secretions of the skin. In addition, fats contain unsaponifiable components, among which cholesterol predominates. Of animal fats, pork fat is the most common — Adeps suillus seu Axungiaporcina (depurata). It is a mixture of triglycerides of stearic, palmitic, oleic and linoleic acids. Pork fat also contains a small amount of cholesterol. It is a white mass almost odorless with a melting point of 34-36 "C. Ointments on pork fat are...

Homogenization of ointments and creams

7940

6878083

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The next stage in the production of ointments is homogenization. This is a specific stage, since when mixing, the desired degree of dispersion of medicinal substances is not always achieved. For homogenization, various equipment is used, such as roller or disc masers, millstones and colloidal mills, as well as homogenizers-dispersants. Roller mazeterki have two or three rolls with a smooth surface, rotating towards each other at different speeds, ensuring the transition of ointment from shaft to shaft and increasing the friction between them. Rolls are made of porcelain, basalt or metal. To maintain the optimal temperature of the ointment entering the rolls, they are made hollow so that, if necessary, water can be supplied inside. Mazeterka is a system of three rolls in contact with...

Hydrophilic bases for ointments and creams

7940

6878082

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Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; gels of clay minerals; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous solutions of medicinal substances; ease of release of medicinal substances, which ensures their high bioavailability; good absorbency into the skin, the bases are easily removed from the application site and washed off with water from the skin. The disadvantages of hydrophilic bases include microbial contamination and rapid drying (this property does not apply to polyethylene oxides), as well as incompatibility with a number of medicinal substances and susceptibility to syneresis, a...

Automatic cartoning equipment ZXM-10B

8916

6887844

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Automatic cartoning equipment is designed for packing bottles, prepackaged ointments and other similar products into cartons. PLC control system. Compliant with GMP standard. Easy and fast size changeover. Reliable product and insert sheet insertion. Reliable automatic controlled cartoning. Versatile labeling such as embossing. Rejection of boxes with a missing insert sheet. User manual and technical data sheet in English. Completeness and operability are guaranteed. We maintain a stock of parts and consumables in stock. The price is based on delivery to the buyer’s city.