Video review of the model
Our service and customer service
One of the most important factors is the intended use of the product, which determines the conditions under which the encapsulated substance is used and its properties are manifested. This determines the choice of film-forming material and the resulting choice of microencapsulation medium. Slow release of the substance by diffusion requires the use of a film-forming material that swells rather than dissolves in the medium in which the microcapsules are used. On the other hand, rapid release can be achieved by selecting a film-forming material that is soluble, meltable or brittle. A further factor is the stability and solubility of the encapsulated substance under microencapsulation conditions. The instability of many substances even at a slight increase in temperature (enzymes, some vitamins, volatile liquids) limits the possibility of using methods involving heating. Methods based on the separation of liquid phases (methods of formation of a new phase from solutions) can be an alternative in this case. In this case, the properties of the substance will determine the choice of dispersion medium and dispersed phase. Of great importance is the cost of the process, so preference is given to methods involving a smaller number of stages and carried out in a continuous mode. The required size of the microcapsules, the content of the encapsulated substance and the efficiency of microencapsulation are also important factors. The above classification of microencapsulation methods, which is based on the nature of the processes occurring during microencapsulation, is rather conventional. In practice, a combination of different methods is often used. Below we will consider the most frequently used in the chemical-pharmaceutical industry methods of microencapsulation.
Pharmaceutical Glossary
Technical specifications
The main component of microcapsules – the substance to be encapsulated – can be in any aggregate state – liquid, solid, gaseous. The existing methods provide the possibility of microencapsulation of both lyophilic and lyophobic substances. The contents of microcapsules may include an inert filler, which is the medium in which the substance was dispersed in the process of microencapsulation, or is necessary for the subsequent functioning of the active substance. The content of the encapsulated substance in the microcapsules is typically 50-95% of the weight of the capsules. This value may vary depending on the technology and conditions of production, the required ratio of shell material and encapsulated substance, as well as on other process parameters: temperature, degree of dispersion, viscosity of the medium, presence of surfactants, etc. The term “microcapsules” or “nanocapsules” can refer to many different structures. One can use molecules within which the active ingredient is trapped, as well as complexes of complex molecules from which nanocapsules or nanospheres are formed. Nanoencapsulation is said to occur when the size of the molecules is less than a few micrometers. When the size of the molecules is less than one millimeter, we speak of microencapsulation. Different classes of substances can be used as shell material or encapsulating matrix: Waxes and lipids: beeswax, candelilla and carnuba waxes, wax emulsions, glycerol distearate, natural and modified fats. Proteins: gelatin, wheat proteins, soy proteins, zein, gluten, etc. Both proteins themselves and their modifications are used. Carbohydrates: starches, maltodextrins, chitosan, sucrose, glucose, ethyl cellulose, acetate cellulose, alginates, etc.
Additional information
Degradable polymers: polypropylene, polyvinyl acetate, polystyrene, polybutadiene, etc. The choice of material of shells or encapsulating matrix depends on the purpose, properties and method of release of the encapsulating agent, as well as on the chosen method of microencapsulation. The contents of microcapsules can be released by mechanical destruction of the shells under pressure, by friction, ultrasonic action, melting, by rupture from the inside by vapors or gaseous substances released under changing external conditions, by interaction of the shell substance with the medium when dissolved in it, as well as by diffusion of the contents when the capsule walls swell in the surrounding liquid. Existing methods of microencapsulation can be divided into three main groups: Physical methods of microencapsulation are based on methods of forming shells by mechanical techniques. This group of methods includes fluidized bed coating, extrusion using centrifuges or through tube-in-tube forming devices, vapor condensation (vacuum spraying). Chemical methods are based on chemical transformations leading to film-forming material, namely – formation of a new phase by cross-linking of polymers, poly condensation and polymerization. Both high molecular weight substances (oligomers or polymers) and low molecular weight substances can be subjected to chemical transformations. Physicochemical methods include coacervation, precipitation of film-forming polymer from aqueous medium by adding a component that reduces its solubility, formation of a new phase by temperature change, evaporation of a volatile solvent, solidification of melts in liquid media, extraction substitution, spray drying, and physical adsorption. When selecting a microencapsulation method, several major factors must be considered.
Order status tracking
Remember me? There's a delivery in the Nice 22/07/2024 10:10
Ella, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 14:30 in Nice . 22/07/2024 10:13
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 22/07/2024 10:20
Lucas, Checking delivery status. The shipment is already in Porto warehouse. Please arrange for pickup. 22/07/2024 10:22
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 22/07/2024 10:30
Ruby, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 22/07/2024 10:34
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/07/2024 10:40
Amelia, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Pittsburgh ? Contact Natalia, she will send the contract and invoice. 22/07/2024 10:41
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 22/07/2024 10:50
Oliver, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 22/07/2024 10:54
Tell me the NJ-120 automatic capsule machine went ? 22/07/2024 11:00
Hazel, good afternoon. Yes, already after lunch you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 22/07/2024 11:01
PU-250 flow-pack packaging machine, please advise delivery status. 22/07/2024 11:10
Hello Hazel, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow until 16:30 22/07/2024 11:11
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Atlanta 22/07/2024 11:20
Hello Alexander, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 22/07/2024 11:22
Natalia hello, what about the counter table tablets and capsules counter TC-10, account #121. 22/07/2024 11:30
Hello Andrew, Our manager Natalia tomorrow until 12:30 will call you on WhatsApp. I see the tracking status, on the carrier's website, the shipment will arrive to Constance in 15 days. 22/07/2024 11:33
I've been calling your office since this morning, and no one's picking up the phone. 22/07/2024 11:40
Good afternoon, Henry! The office will be open from 9:00 GMT. We'll be in touch. 22/07/2024 11:43
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS