There are some requirements for the granulating liquid, one of them is that the granulating liquid should not dissolve the active substance. Water, an aqueous solution of ethanol, acetone and methylene chloride can be used as a granulating liquid. A wide range of substances are used as binding agents for wet granulation in modern pharmaceutical...
Dry granulation is a method in which a powdery material (a mixture of medicinal and auxiliary substances) is compacted to produce a granulate. Dry granulation is used in cases where wet granulation affects the stability and/or physico-chemical characteristics of the medicinal substance, as well as when the medicinal and auxiliary substances are poorly compressed after...
The ozone tunnel sterilization dryer ZXP-MG is used for drying and sterilization after washing plastic containers for eye drops, oral liquids in the pharmaceutical and food industries. The heating system and the ozonator of this machine can be controlled automatically and in a preset mode. The speed of the conveyor is regulated within a specified…
Tableting (pressing) is the process of forming tablets from granular or powdery material under pressure. In modern pharmaceutical production, tableting is carried out on special presses called tablet machines.
Spiral multilayer dedusting device for tablets and capsules is designed and manufactured on the basis of international technologies and performs two functions: loading tablets and dedusting tablets. The advantage of this model lies in the long paths through which the tablets pass during the dedusting process, with continuous turning and polishing. The dedusting agent effectively but…
After the grinding and sieving operations, mixing follows, the purpose of which is to obtain a homogeneous mixture of powders. Mixing is usually carried out in parallel with grinding. This leads to the alignment of particle sizes and obtaining a more homogeneous mass. If a component is included in the mixture in a small amount,...
The whole pressing process is proposed to be divided into three stages: compaction (pre-pressing); formation of a compact body; volumetric compression of the resulting compact body. At the first stage of pressing, under the influence of an external force, the material particles converge and seal due to their displacement relative to each other and filling...
Fluidized bed dryer dryer uses a stream of hot air to keep the pellets in a “suspended” state in the pseudo-liquefied layer and dry them quickly, the spent water evaporates with the air flow. This equipment is used in the production of medical herbal preparations, combined powders, granules, lumpy materials, chemical products, etc. Quick drying….
To push the compressed tablet out of the matrix, it is required to expend force to overcome friction and adhesion between the side surface of the tablet and the wall of the matrix. Taking into account the magnitude of the ejection force, additives of antifriction (sliding or lubricating) substances are predicted. As an example, the...
Fluidized bed dryer dryer uses a stream of hot air to keep the pellets in a “suspended” state in the pseudo-liquefied layer and dry them quickly, the spent water evaporates with the air flow. This equipment is used in the production of medical herbal preparations, combined powders, granules, lumpy materials, chemical products, etc. Quick drying….