СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / GRANULATION PROCESS IN TABLET PRODUCTION / Binders for wet granulation

Binders for wet granulation

There are some requirements for the granulating liquid, one of them is that the granulating liquid must not dissolve the active ingredient. Water, aqueous ethanol solution, acetone and methylene chloride can be used as granulating liquid. A wide range of substances are used as binders for wet granulation in modern pharmaceutical production, for example: starch (5-15 % g/g), starch derivatives, cellulose derivatives, which improve the plasticity of granules, as well as gelatin (1-3 % g/g) and PVP (3-10 % g/g). The most common and effective wet granulation binder in the modern pharmaceutical industry is a synthetic polymer such as Collidon (PVP), the various grades of which (Collidon 25, 30 and 90F) are widely available on the market.

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Information updated: 07 / 07 / 2026
Available for
Production: 1 year на оборудование для влажной грануляции

Model: Wet granulation

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Equipment leasing with advance payment from 10%

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Our service and customer service

Plasdon polymers have excellent bonding ability, good film forming properties, surfactant properties and high solubility in water and many solvents used in pharmaceutical applications. Due to this combination of properties, these polymers are widely used in a number of pharmaceuticals. Plasdone polymers have long been used as binding agents in wet granulation. Plasdone®S-630 Copovidone is a synthetic 60:40 linear polymer of N-vinyl-2 pyrrolidone and vinyl acetate. With its unique properties, Plasdone S-630 is well suited as a tablet binder for direct pressing and dry granulation applications, as well as a wet granulation binder.

Pharmaceutical Glossary

Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

The granules obtained with PVP are hard, easy to bulk, forming harder tablets with low brittleness. PVP polymer improves the solubility of the active ingredient by forming complexes. In addition, PVP acts as a crystallization inhibitor. The regularities presented below were identified by BASF’s fine chemistry department. They are discussed using Collidon as an example. Wet granulation using Collidon 25, Collidon 30 and Collidon 90F generally results in a harder granular material with better bulk properties than other binders – less abrasion and higher bond strength. The polymer content of the granulating fluid used can vary from Collidon 25 – 2-5%; Collidon 30 – 2-5%; Collidon 90F – 1-3%.

Additional information

Thus, BASF’s research showed that Collidon 90F produced the highest tablet hardness at the same pressing pressure. All binders were used in the amount of 3%. Based on the data presented, it can be concluded that the increased hardness and reduced brittleness of calcium phosphate tablets when Collidon 30 is used as a binder in the wet granulation process. In addition to Collidon, there are a large number of substances used as binders in the pharmaceutical industry. Let us consider two of them. PlasdonPPovidone is a series of synthetic water-soluble homopolymers of N-vinyl-2 pyrrolidone.

Order status tracking

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Avery
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 10/07/2026 21:35

Roman Tsibulsky
Hello Avery, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 10/07/2026 21:39

Emma
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 10/07/2026 21:45

Roman Tsibulsky
Emma, Checking delivery status. The shipment is already in Mont St. Michel warehouse. Please arrange for pickup. 10/07/2026 21:47

Elizabeth
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Hum, but immediately upon arrival send it to Milan. 10/07/2026 21:55

Roman Tsibulsky
Hello Elizabeth, we will try to resolve this issue for you. 10/07/2026 21:56

Victoria
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 10/07/2026 22:05

Roman Tsibulsky
Hello Victoria, We are on time, tomorrow until 18: 30 a driver will contact you about unloading. 10/07/2026 22:09

Harper
Remember me? There's a delivery in the Valletta 10/07/2026 22:15

Roman Tsibulsky
Harper, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 16:30 in Valletta . 10/07/2026 22:19

Savannah
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 10/07/2026 22:25

Roman Tsibulsky
Savannah, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 10/07/2026 22:28

Owen
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 10/07/2026 22:35

Roman Tsibulsky
Owen, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer between 16:00-18:00. We will report back immediately. 10/07/2026 22:36

Mia
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Bordeaux. 10/07/2026 22:45

Roman Tsibulsky
Hello Mia, Delivery status checked, tomorrow until 15:30 is arriving at Bordeaux . The driver will call you beforehand. 10/07/2026 22:47

Owen
Today we were promised delivery of a blister machine for MN-14 tablets and capsules, remember us ? No one's called us back. 10/07/2026 22:55

Roman Tsibulsky
Hello Owen, Our manager Natalya the day after tomorrow will dial the driver, also we ask you yourself to the transportation company. 10/07/2026 22:58

Layla
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 10/07/2026 23:05

Roman Tsibulsky
Layla, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Fort Worth ? Contact Natalia, she will send the contract and invoice. 10/07/2026 23:07