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Insoluble coatings include ethyl cellulose, surfactants, etc. These coatings are created using some cellulose derivatives, which are applied to the tablet in the form of solutions. To increase the strength and elasticity of the shells, plasticizers are introduced into their composition. The mechanism of drug release from tablets with insoluble membranes is that digestive juices can quickly penetrate the pores of the membrane and dissolve the active substance of the tablet or cause it to swell. In the first case, the dissolved substance diffuses through the film in the opposite direction - towards the gastrointestinal tract under the influence of the difference in concentrations, in the second - the membrane breaks due to the increase in tablet volume, after which the drug is released in the usual way. The uniform release of the drug substance through the intact membrane occurs regardless of the composition, enzyme action and pH of the medium in the gastrointestinal tract. It depends only on the solubility and pore size of the shell, which can be modified as necessary. Therefore, it is possible to obtain tablets with a pre-calculated rate of drug release.
Specifications
Water-soluble coatings improve the appearance of tablets, correct their taste and smell, protect against mechanical damage, but do not protect against moisture from the air. Water-soluble membranes form PVP, MC, Na CMC, etc., applied to tablets in the form of water-ethanol or aqueous solutions. Coatings soluble in gastric juice - films that protect against moisture, provide rapid dissolution in the stomach (within 10-30 minutes). The film-forming agent of this group includes polymers having diethylaminomethyl cellulose, sugar para-aminotenzoates, and cellulose acetate in the amino group molecule. The tablets are coated with solutions of these substances in organic solvents - ethanol or isopropanol, which volatilize during coating and drying. Enteric coatings protect the drug substance contained in the tablet from the acid reaction of the gastric juice, protect the gastric mucosa from the irritating effect of certain drugs, localize the drug substance in the intestine, prolonging its action to a certain extent, and also have a pronounced moisture protective effect. The process of dissolution of the membranes in the body is due to the action of a complex of enzymes on them to various solubilizing substances contained in the intestinal juice.
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As film-forming agents for the preparation of enteric coatings, high molecular weight compounds are used. They dissociate in a neutral and alkaline environment with the formation of insoluble salts. Both natural substances are used: shellac, casein, keratin, paraffin, ceresin, cetyl alcohol, and synthetic products: stearic acid in combination with fats and bile acids, butyl stearate, acetylphthalyl cellulose, polyvinyl acetate flatate, polyacrylic resins (Eudragid). The listed film-forming agents are applied to tablets in the form of solutions. To obtain colored membranes, pigments and dyes are added to the solutions. By varying various polymers and different film thicknesses, it is possible to achieve tablet disintegration in a specific section of the intestinal tract. Enteric coatings withstand the effects of gastric juice for 2-4 hours or more, which allows such dosage forms to pass through the stomach unchanged; in the intestinal juice, they disintegrate within 1 h, providing the release of the drug substance in the intestine. Insoluble coatings are microporous films for the controlled release of a drug substance. The main purpose of this type of coating is to protect tablets, pellets or granules from mechanical damage and from exposure to atmospheric moisture, eliminate the unpleasant odor and taste of the drug substance, and prolong its action.
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- Logo Tablet Pill
- Automatic hydraulic tablet press
- Tablet Press Rotary Tablet Press
- Spray gun for coating tablets, dragees and nuts
- Machine for filling liquids in plastic and glass bottles
- Silica gel bagging machine
- Blister Packing Machine
- Printer for printing on tablets, dragees and capsules, sweets
- Equipment for filling liquids and sealing glass ampoules
- Mechanical glue filling machine in aluminum tubes
- Washing plastic and glass penicillin vials and ampoules
- Automatic Plastic Ampoule Forming Machine
- Screw system for feeding powder into hoppers of machines and containers
- V-shaped mixer for mixing dry powder material
- Emulsifier of cream and ointments for the cosmetics industry
- Machine for packing blisters of tablets, gelatin capsules and dragees
- Semi-automatic machine for filling steel barrels with liquid
- The machine for filling medicinal decoctions in a plastic bag
- Induction Welding Machine Aluminum Control Membrane
- Automatic compact doy pack machine
- The printer for printing on any surface of the expiration date and date
- Cardboard Box Cellophane Wrapping Machine
- High-precision high-speed electronic detector for weight control
- Melting analyzer to analyze the melting suppository process
- Melting analyzer to determine the melting point of drugs
- An analyzer for measuring the speed and degree of dissolution of tablets
- Gelatin Viscosity Analyzer
- Laboratory device for determining the hardness of tablets and granules
- Magnetic mixer for mixing solutions and liquids
- Constant Temperature Vacuum Drying Oven
- Electronically controlled peristaltic pumps
- Emulsifier for pharmaceutical and cosmetic ointments and cosmetics
- Knife type laboratory mill with raw material loading
- Semi-automatic machine for granules, dragees, boilies
- Pneumatic machine for dispensing liquids, creams and ointments
- Printer for embossing on the package batch number and expiration date
- Compact rotary tablet press for tablet pressing
- Tablet press for the chemical and food industries
- Tablet Press Rotary Tablet Press
- Coating pan for coating tablets and capsules
- Equipment for packing powders in penicillin vials
- Machine for dosed filling tubes with ointment and cream
- Hard Gelatin Capsule Powder Filling Machine
- Spray dryer for fine powder
- Dosing machine for feeding powders into plastic cans
- Equipment for polishing and removing dust from gelatin capsules
- Machine for counting and filling tablets and capsules into plastic bottles
- The device for the vacuum transportation of powders and bulk products
- Granulator for dry and wet granulation of powder masses
- Laboratory Vacuum Freeze Dryer
- Orientation equipment for plastic bottles
- Desktop Vacuum Sealing Machine for Plastic Bags
- Packing machine for packing piece products in flow packs
- Packing machine for tablets and capsules in soft strip packaging
- Bulk packing of bulk materials in plastic and paper bags
- Equipment for individual packing of tea in pyramids
- Labeling machine for glass and plastic bottles
- Checker Dust Remover and Tablet Dispenser
- Gelatin Gel Strength Testing System
- Moisture analyzer for analyzing the moisture content of powder or granules
- Transparency analyzer for measuring gelatin transparency
- Device analyzer for measuring tablet hardness
- The analyzer for measuring the thickness of gelatin capsules and tablets
- Tester for monitoring the process of decomposition of solids
- Tablet solubility, abrasion and hardness meter
- Multi-Purpose Laboratory Powder Mixer
- Capsule or tablet blister filling machine
- Vibrating screen for industrial use
- Fluid heating machine with integrated magnetic mixer
- Hard gelatine capsule powder filling capsule
- Digital pump dispenser for filling liquids into ampoules and vials
- Semi-automatic capsule for filling capsule powder