СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

The stage of preparation of the suppository base begins with the sizing of its components. In the first stainless steel reactor with a steam jacket melt paraffin, in the second reactor melt hydrofat by supplying steam into the steam jacket. The heated hydrofat is transferred to the reactor with pre-melted paraffin by means of a pump. The mixture is heated to a temperature of 60-70 ° C and cocoa butter is added. In order to avoid changes in the modification of cocoa butter, heating should not exceed 70 ° C and be prolonged. After complete melting of the base it is stirred for 40 min with a stirrer. The melting point and the time of complete deformation are determined in the finished base.

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Information updated : 09 / 12 / 2025
In stock
Manufacturer : 1 year for Preparation of suppository base

Model: Suppository base

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Our service and customer service

The preparation of the suppository mass is carried out in a reactor, where the ready base is fed with compressed air and drug substances are added. As an example, the LT series reactor-mixer manufactured by the Italian company ZUMA s.r.l. is used. Mixers of this series are designed for the preparation of suppository mass, creams, ointments, etc. and are available in four sizes with the volume of the working tank 30, 60, 140 and 250 liters. The working tank of the reactor is a polished stainless steel tank with a water jacket for heating and melting of the mixture. The tank can be rotated by 90° for easy draining and washing. The agitator blades of the reactor are equipped with scraper blades. All working parts of the apparatus are made of stainless steel. The mixer reactor is equipped with safety guards and is manufactured according to international standard.

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Technical specifications

If the melting temperature of the base is higher or lower than the specified one, then paraffin or hydrofat is introduced into the base heated to 60-70 ° C with thorough mixing. The base is filtered through a druk-filter using a brass mesh or belting, analyzed by melting temperature, solidification and time of full deformation and transferred to the apparatus department.
Druk filters are pressurized capacitive filters. Druk-filters are vertical vessels (usually with a jacket) with an elliptical bottom.
The vessel filter housing can be open or closed. The upper part of the housing is fed with the slurry to be separated. The filtrate is discharged from the lower part. During filtration, compressed gas is fed into the slurry-filled housing.

Additional information

The filter baffle is located on the false bottom. The resulting sludge is washed, dried and discharged by means of an agitator through a hatch located on the side of the housing or in the center of the false bottom. In some designs, the sludge is removed after lowering the false bottom by moving the filter cloth belt, which passes through the regeneration chamber at the end of the sludge discharge. Druk filters are known, the body of which can be rotated by 90-180° in the trunnions fixed on its cylindrical part. Druk filters are used to separate medium and well-filtered suspensions in medium and low-tonnage productions.

Order status tracking

Roman Tsibulsky +79853643808 now online

Samuel
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 22/12/2025 19:44

Roman Tsibulsky
Samuel, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 22/12/2025 19:45

Gabriel
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled tomorrow until 15:30 to open the box and test. 22/12/2025 19:54

Roman Tsibulsky
Gabriel, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 22/12/2025 19:56

Aubrey
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 22/12/2025 20:04

Roman Tsibulsky
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Aubrey, this chat is only for tracking shipments. 22/12/2025 20:07

Chloe
HX-6 Plastic Tube Filling and Sealing Machine in Edinburgh? Price delivery terms and conditions 22/12/2025 20:14

Roman Tsibulsky
Chloe, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 22/12/2025 20:18

Luna
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 22/12/2025 20:24

Roman Tsibulsky
Luna, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Tucson ? Contact Natalia, she will send the contract and invoice. 22/12/2025 20:26

Liam
To what address to send you samples of bottles and caps to send them to the factory ? Regards Liam. 22/12/2025 20:34

Roman Tsibulsky
Good day, Liam We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 22/12/2025 20:36

Lily
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 22/12/2025 20:44

Roman Tsibulsky
Lily, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 22/12/2025 20:47

Zoe
Good afternoon, please confirm that tomorrow until 14:30 we will receive our shipment in Salzburg? Contact the transportation company. 22/12/2025 20:54

Roman Tsibulsky
Hello Zoe ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Salzburg in a few days. Please expect it. 22/12/2025 20:57

Riley
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 22/12/2025 21:04

Roman Tsibulsky
Riley, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer as stipulated in the contract. We will report back immediately. 22/12/2025 21:07

Owen
Remember me? There's a delivery in the Madrid 22/12/2025 21:14

Roman Tsibulsky
Owen, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be tomorrow until 15:30 in Madrid . 22/12/2025 21:15