СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / MAKING SUPPOSITORIES IN PRODUCTION / Preparation of suppository base

Preparation of suppository base

The stage of preparation of the suppository base begins with the sizing of its components. In the first stainless steel reactor with a steam jacket melt paraffin, in the second reactor melt hydrofat by supplying steam into the steam jacket. The heated hydrofat is transferred to the reactor with pre-melted paraffin by means of a pump. The mixture is heated to a temperature of 60-70 ° C and cocoa butter is added. In order to avoid changes in the modification of cocoa butter, heating should not exceed 70 ° C and be prolonged. After complete melting of the base it is stirred for 40 min with a stirrer. The melting point and the time of complete deformation are determined in the finished base.

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Information updated : 28 / 03 / 2026
In stock
Manufacturer : 1 year for Preparation of suppository base

Model: Suppository base

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The preparation of the suppository mass is carried out in a reactor, where the ready base is fed with compressed air and drug substances are added. As an example, the LT series reactor-mixer manufactured by the Italian company ZUMA s.r.l. is used. Mixers of this series are designed for the preparation of suppository mass, creams, ointments, etc. and are available in four sizes with the volume of the working tank 30, 60, 140 and 250 liters. The working tank of the reactor is a polished stainless steel tank with a water jacket for heating and melting of the mixture. The tank can be rotated by 90° for easy draining and washing. The agitator blades of the reactor are equipped with scraper blades. All working parts of the apparatus are made of stainless steel. The mixer reactor is equipped with safety guards and is manufactured according to international standard.

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Technical specifications

If the melting temperature of the base is higher or lower than the specified one, then paraffin or hydrofat is introduced into the base heated to 60-70 ° C with thorough mixing. The base is filtered through a druk-filter using a brass mesh or belting, analyzed by melting temperature, solidification and time of full deformation and transferred to the apparatus department.
Druk filters are pressurized capacitive filters. Druk-filters are vertical vessels (usually with a jacket) with an elliptical bottom.
The vessel filter housing can be open or closed. The upper part of the housing is fed with the slurry to be separated. The filtrate is discharged from the lower part. During filtration, compressed gas is fed into the slurry-filled housing.

Additional information

The filter baffle is located on the false bottom. The resulting sludge is washed, dried and discharged by means of an agitator through a hatch located on the side of the housing or in the center of the false bottom. In some designs, the sludge is removed after lowering the false bottom by moving the filter cloth belt, which passes through the regeneration chamber at the end of the sludge discharge. Druk filters are known, the body of which can be rotated by 90-180° in the trunnions fixed on its cylindrical part. Druk filters are used to separate medium and well-filtered suspensions in medium and low-tonnage productions.

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Lily
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 03/04/2026 04:47

Roman Tsibulsky
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Lily, this chat is only for tracking shipments. 03/04/2026 04:48

Sophia
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Houston. We want to track the delivery status. 03/04/2026 04:57

Roman Tsibulsky
Sophia, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 03/04/2026 05:00

Ellie
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 03/04/2026 05:07

Roman Tsibulsky
Ellie, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 16:30. We will report back immediately. 03/04/2026 05:09

Carter
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Tbilisi ? 03/04/2026 05:17

Roman Tsibulsky
Hello Carter, your shipment is in the customs warehouse, tomorrow until 16:30 your manager Natalia will contact you. 03/04/2026 05:17

Ella
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Washington ( Europe) ? How much time for delivery ? 03/04/2026 05:27

Roman Tsibulsky
Ella, hello! We have many customers from your city. Delivery to this region is made by EMC. 03/04/2026 05:29

Henry
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 03/04/2026 05:37

Roman Tsibulsky
Henry, Checking delivery status. The shipment is already in Santorini warehouse. Please arrange for pickup. 03/04/2026 05:38

Grace
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 03/04/2026 05:47

Roman Tsibulsky
Hello Grace, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 03/04/2026 05:50

Grace
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Mariehamn ? 03/04/2026 05:57

Roman Tsibulsky
Good afternoon, Grace! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 03/04/2026 05:58

Skylar
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in Fort Worth 03/04/2026 06:07

Roman Tsibulsky
Hello Skylar, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 03/04/2026 06:09

Zoe
Good afternoon, I am hoping in the interval from 14:00-16:00 to get the UNIC 600A Tablet Press in Pilsen ! Please comment. 03/04/2026 06:17

Roman Tsibulsky
Good day, Zoe! Our manager has communicated with the delivery service, the equipment will be delivered to Pilsen at your address. Please let us know when you receive it. 03/04/2026 06:21