СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

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СATALOGUE / DRYING OF BULK MATERIALS IN A FLUIDIZED BED / Combining spray drying and freeze drying

Combining spray drying and freeze drying

The evaporation surface and the thickness of the frozen material layer play a significant role in improving heat and mass transfer. Increasing the evaporation surface is achieved by increasing the dispersibility and specific surface area of the material. This can be accomplished by atomization and additional pulverization of the frozen product, which allows to obtain a product of high dispersibility. According to preliminary estimates, the cost of removing 1 kg of moisture by spray drying is 6 times less than freeze drying. At the same time, transportation costs are significantly lower, and the condition of the products is stable during long-term storage. However, research has shown that spray drying can only be used for microorganisms that can withstand high temperatures.

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Information updated: 07 / 05 / 2026
Available for
Production: 1 year на распылительную и сублимационную сушилки

Model: Combining spray drying and freeze drying

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Powders obtained by spray drying and combined spray and freeze drying have fundamental differences in particle shape. At the same time, the residual moisture content, surface properties of particles obtained by these two methods were similar. In both cases, the bulkiness was unsatisfactory. With the use of additives, an improvement in bulkiness was observed. In view of the above, it becomes obvious that there is a need to improve the energy efficiency of freeze dehydration technology, to develop new equipment, to create combined drying methods aimed at improving the quality of the obtained products. One of the tasks of improving the process of freeze drying (reducing the duration, energy consumption of the process) with simultaneous solution of the problems of quality of the obtained products can be solved by transition from drying in vacuum to drying at atmospheric pressure.

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Articles — A genre of journalism in which the author sets the task of analyzing social situations, processes, phenomena, primarily from the point of view of the regularities underlying them.

Technical specifications

For most crops, however, freeze drying remains the only suitable method. Recent research by scientists has shown that spray drying and freeze drying can be combined in a single process to produce protein-rich dry powders, with the main advantage of obtaining a highly dispersed product.
The process was carried out in two stages: spraying of the solution in a metal container filled with liquid nitrogen under constant shaking; freeze drying in a Crist vacuum lyophilizer. At the same time, the quality of products dried by the combined method (degree of preservation of valuable properties, original structure, activity of ingredients) is not inferior to freeze-dried in vacuum.

Additional information

The products have better bulkiness and morphology, and there is no sintering of the top layer. The powders obtained in this way can be used for further encapsulation, pressing, epidermal administration, as well as for increasing the solubility of poorly soluble substances. Some scientists have also investigated the effect of the drying method on powder friability, which depends on a combination of different factors: size, shape, and surface properties of the particles. The comparison of spray and combined spray and freeze drying methods was carried out in terms of such indicators as: particle size and shape; moisture content, physical and chemical properties; the influence of additives and coatings on the friability of powders.

Order status tracking

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James
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 13/05/2026 06:28

Roman Tsibulsky
Good day, James! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 13/05/2026 06:32

Zoey
Good day, I want the day after tomorrow to get FF-02 tablet and capsule filling machine in Bucharest? 13/05/2026 06:38

Roman Tsibulsky
Good afternoon, Zoey! We have contacted the transportation company, your shipment is arriving in Bucharest without delay. Please wait for a call from a representative of Business Lines. 13/05/2026 06:41

Alexander
I've been calling your office since this morning, and no one's picking up the phone. 13/05/2026 06:48

Roman Tsibulsky
Good afternoon, Alexander! The office will be open from 9:00 GMT. We'll be in touch. 13/05/2026 06:52

Benjamin
Natalia tell me, automatic double-sided labeling machine ST-36 has left the factory, invoice #118. 13/05/2026 06:58

Roman Tsibulsky
Hello Benjamin, The equipment has been shipped from the transit warehouse and delivery is proceeding as planned. No delays are expected. 13/05/2026 07:01

Samuel
Good afternoon! semi-automatic liquid filling machine in barrels DF-13 , a copy of the payment is sent to the post. Start the order to work. 13/05/2026 07:08

Roman Tsibulsky
Samuel, good afternoon! We have seen your payment, we receive SMS from the bank. Please send drawings of barrels and answers to our questions in correspondence. 13/05/2026 07:12

Luna
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 13/05/2026 07:18

Roman Tsibulsky
Hello Luna, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 13/05/2026 07:20

Maya
Run through the order. V-shaped mixer for powders VM-50 and Mechanical tablet press PP-28 are waiting. 13/05/2026 07:28

Roman Tsibulsky
Maya, Checking delivery status. The shipment is already in Strasbourg warehouse. Please arrange for pickup. 13/05/2026 07:30

Jackson
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Alexandrovka, but immediately upon arrival send it to Rome. 13/05/2026 07:38

Roman Tsibulsky
Hello Jackson, we will try to resolve this issue for you. 13/05/2026 07:42

Gabriel
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Tucson. We want to track the delivery status. 13/05/2026 07:48

Roman Tsibulsky
Gabriel, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 13/05/2026 07:51

Scarlett
In Butrint ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 13/05/2026 07:58

Roman Tsibulsky
Good afternoon, Scarlett! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 13/05/2026 08:02