PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Pressing stages for powdered materials

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The whole pressing process is proposed to be divided into three stages: compaction (pre-pressing); formation of a compact body; volumetric compression of the resulting compact body. At the first stage of pressing, under the influence of an external force, the material particles converge and seal due to their displacement relative to each other and filling voids. The forces overcome in this case are insignificant, the seal becomes noticeable even at low pressures. The applied energy is mainly spent on overcoming internal (between particles) and external (between particles and matrix machines) friction.

Preparation and filling of gelatin capsules

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6578158

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The calculated amount of purified water is poured into the container, which is heated to a temperature of + 65 ° C in a gelatin mass preparation apparatus, and a stirrer is turned on. Then glycerin is poured with nipagin and gelatin is filled in. The gelatin mass is mixed for 1.5 hours until the gelatin is completely dissolved, then, with the agitator turned off, it settles for 0.5—1.5 hours. After that, the gelatin mass is filtered through a sieve and its viscosity is measured using a viscometer. If the viscosity indicators do not correspond to the norm, the ratio of water and gelatin is recalculated. The filler solution is prepared according to the technological instructions. The prepared gelatin mass and filler in the required...

Film coatings of tablets

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A film coating is a thin shell formed on the surface of a microsphere (pellets). Tablets or granules after drying of the film-forming substance solution applied to their surface. The thickness of the film coating layer is approximately from 5 to 50 microns. The droplets of the coating liquid are sprayed onto the initial particles. The supplied process air evaporates the liquid and dries the film layer on the surface of the particles. The small droplet size and low viscosity ensure uniform distribution of the film on the particle surface. An important point when applying the coating is a very uniform application of the coating material. The coatings must be dense, without mechanical damage and cracks. Film coating is an effective way of applying protective...

Film coatings for modified-release applications

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6578533

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Modified release film coatings can be applied to pharmaceutical products to achieve modification, control the release of a medicinal substance. All coatings on the kinetics of drug release can be divided into the following four types: Coatings that provide periodic release of LV (intermittent release). This type includes coatings resistant to the effects of gastric juice — intestinal soluble coatings. Coatings that provide instant release of LV. Coatings that provide a steady (continuous) release of LV. Coatings that provide delayed (delayed) release of LV. Let's look at each type of coatings in more detail. Coatings that provide periodic release of the medicinal substance. This type of coating provides a prolonged effect of the dosage form, when injected into the body, LV is released in portions,...

Coatings that provide medicine substance release

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With this type of coating, the medicinal substance from the tablets can be released instantly. These types of coatings include polymers developed by BASF: polyvinyl alcohol (PVA), Kollicoat IR white and Kollicoat Protect. PVS-based films are very elastic, but the coating process is possible only in a narrow range of varying technological parameters. This polymer is rapidly dispersed in water during the preparation of the dispersion for the film coating, forms shiny, non-sticky and very flexible films that do not crack during storage. The addition of a plasticizer is not required to create a coating. Kollicoat IR can be replaced by GPMC and other coatings with immediate release of LV in new tablet preparations. The use of Kollicoat IR increases the cost-effectiveness of the coating...

Problems encountered during coating application

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As in the case of sugar coatings, problems may arise after or during the application of the film coating. Tablets, Pellets and granules on which the coating is applied may not be strong enough or delaminate during the coating process. Due to the fact that film coatings are relatively thin, their ability to hide defects is significantly lower than that of sugar coating. When using a film coating, various problems may arise. One example is sticking, which occurs when the fluid flow rate exceeds the drying rate, which causes the gluing of tablets, pellets and granules and their further destruction.

Basic requirements for tablets

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The following requirements are imposed on tablets: dosing accuracy — uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength — hardness, brittleness, fragility — characterize the quality of tablets; tablets must have sufficient strength to remain intact under mechanical influences during packaging, transportation and storage; disintegration or solubility — the ability to disintegrate or dissolve within the time limits established by the relevant scientific and technical documentation (NTD) for certain types of tablets. The accuracy of dosing depends on the uniformity of the tableted mass, which is ensured by careful mixing of medicinal and auxiliary substances and their uniform distribution in the total...

Organization of modern ointment production

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General recommendations for the selection of pharmaceutical equipment. The right choice of equipment is one of the most important issues of the organization of modern industrial production. Reliable, optimally selected and well-proven equipment largely determines the quality of the manufactured product, its competitiveness, and is also a guarantee of the successful development of production as a whole. The selection of equipment (for the pre-modern production of pharmaceutical products is carried out on the basis of many criteria. First of all, the equipment must be designed and optimally suited for the technological processes of production of a particular pharmaceutical product. Usually, preference is given to production machines and installations that allow several technological operations to be carried out at once, since their structural elements and operating...

Orientation, closing unloading, capsule cleaning

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6578474

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There are empty capsules in the capsule bin. The capsules move down into two magazines, are aligned by the sorting unit and lowered into the corresponding cells. At the first stage of this operation, the first (internal) one is loaded a row of capsules, on the second one — the second (external) one is loaded a number of capsules. After the capsule magazine there is a narrow calibration hole. Only geometrically correct capsules can pass through this hole. In case of irregular shaped capsules that are unable to pass through the calibration hole, the cells are blocked, recognized by the scanner and excluded from the further filling process.

Leukoplasty production process

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A band-Aid (Leucoplastrum), or a sticky elastic band-aid smeared (Emplastrum adhaesivum elasticum externum). It is used to hold bandages, to bring the edges of wounds closer together, to stretch the limb in case of fracture, etc. It consists of the following components: 25.7 parts of natural rubber, 20.35 parts of rosin, 32 parts of zinc oxide, 9.9 parts of anhydrous lanolin, 11.3 parts of liquid paraffin and 0.75 parts of neozone D. The adhesive plaster production process includes several stages: the dissolution of natural rubber and rosin in gasoline, the preparation of an alloy of lanolin with liquid paraffin, mixing it with finely ground zinc oxide and the preparation of a paste of anti-oxidant rubber. The application of the finished mass of adhesive plaster to...