The pins are lowered into the melt of the gelatin mass, which solidifies on them in a thin shell. The shell is removed, filled, and then molded (the mold is fixed by drying under a certain regime). The described method has found wide application in the industry in the manufacture of hard gelatin capsule shells, being, in fact, the only one. After the manufacture of hard capsule shells, they are filled with drugs and excipients. Filling of hard gelatin capsules. In addition to the active substance, auxiliary ingredients are introduced into the capsule filling mass (in order to give it the necessary technological characteristics, as well as to set, if necessary, biopharmaceutical properties), which should be biologically indifferent, namely: Fillers, or diluents, are substances that give the capsule filling mass the required optimal volume.

For these purposes, in the manufacture of drugs in the form of hard capsules, milk sugar, microcrystalline cellulose (MCC), calcium phosphate bivalent and other substances are used, which allow to adjust the bulk density and give the filler the necessary bulkiness. MCC, in addition, allows to slow down the absorption process, which is important for prolonged action of the drug. Sliding agents – substances that give the capsule filling mass the necessary bulkiness. Usually calcium or magnesium stearate, stearic acid, talc are used. Their amount, as a rule, is 0.5-2.0 %. For example, the introduction of 0.1-0.3 % aerosil or magnesium stearate with 0.5-1.0 % talc may be sufficient. Disintegrants – substances that promote deaggregation of the encapsulated powder mass.