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As a result of the first four examples, the coated particles can be either compressed into tablets or placed in hard gelatin capsules. The drug substance-ion exchange resin complexes can be dispersed in viscous liquids to form liquid suspensions. It is important to recognize the fact that a sustained-release dosage form usually contains an extremely high amount of drug substance, which can cause problems if the initial dose is released quickly. This phenomenon is called “dose release” and can be eliminated if: the film coating is mechanically strong and moisture resistant; the application of the film to the material is uniform; and the drug substance is not chewed (crushed) before swallowing. Coatings providing delayed (delayed) release of the medicinal substance. When using dosage forms with delayed (delayed) release of a medicinal substance, the duration of action of the medicinal substance is increased by prolonging its release. As such a coating can be used a polymer brand Kollicoat SR 30D, the formulation of which consists of polyvinyl acetate (27%), KZO povidone (2.7%) and sodium lauryl sulfate (0.3%) as stabilizers and water (70%).
Kollicoat SR has good film-forming properties, swells easily in water, has pH-independent action and provides a strong stable delayed-release effect of the drug.
Pharmaceutical Glossary
Technical specifications
This type of coating is used in prolonged release dosage forms where an initial dose of a drug substance is released into the body and the remaining (maintenance) doses are released at a constant rate to ensure that the desired therapeutic concentration is maintained. Dosage forms with continuous, evenly prolonged release provide a sustaining effect of the drug substance. They are more effective than forms with periodic release, as they provide a constant concentration of drug in the body at the therapeutic level without pronounced extremes, do not overload the body with excessively high concentrations. Dosage forms using sustained-release coatings avoid the need for repeated administration of the drug into the body, especially for those medicine that require maintaining a constant concentration in the blood for a long period of time. In addition, sustained release is used for high-dose medicine, the rapid release of which causes undesirable side effects (e.g., ulcer formation with rapid release of potassium chloride in the GI tract). Methods of creating drug products with sustained release of the drug substance include: increasing the particle size of the drug substance; placing the drug substance in a matrix; coating the drug substance or a dosage form containing the drug substance; and forming complexes of the drug substance with materials such as ion exchange resins.
Additional information
Materials suitable for sustained-release coatings are: a mixture of waxes (e.g. beeswax) with glycerol monostearate, stearic acid, palmitic acid, glycerol monopalmitate and acetyl alcohol. They form polymers that dissolve slowly or degrade in the GI tract; shellac and zein, which do not degrade at low pH values; ethylcellulose, which forms a membrane around the dosage form that does not degrade in the GI tract. However, it is permeable to water, which dissolves the drug substance, as a result of which the latter diffuses into the GI tract; acrylic resins, the mechanism of action of which is similar to the action of ethylcellulose, i.e. there is a controlled diffusion of the drug substance through the coating; cellulose acetate (diacetate or triacetate); silicone elastomers. The development of sustained-release medicine using film coating technology can be accomplished by various methods, such as applying suitable film coatings to: dry granules (both heterogeneous and spheronized); microspheres containing the drug substance or coated with the drug substance; crystals of the drug substance; drug substance-ion exchange resin complexes; tablets (including minitabs).
Order status tracking
Mixer with paddle for powders CX-100 what is the exact packing size ? 22/10/2024 11:22
Liam, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 22/10/2024 11:24
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Bratislava ? 22/10/2024 11:32
Hello Joseph, your shipment is in the customs warehouse, between 12:00-14:00 your manager Natalia will contact you. 22/10/2024 11:34
Hello, is it possible to buy your blistering machine for tablets and capsules MN-80 1 piece with delivery to Seattle ( Europe) ? How much time for delivery ? 22/10/2024 11:42
Aiden, hello! We have many customers from your city. Delivery to this region is made by EMC. 22/10/2024 11:43
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 22/10/2024 11:52
Hello Gabriel, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Rotterdam to 50 working ( not calendar) days. Action taken. 22/10/2024 11:53
PU-250 flow-pack packaging machine, please advise delivery status. 22/10/2024 12:02
Hello Benjamin, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow until 15:30 22/10/2024 12:03
LW-35 automatic PVC+cardboard blister packaging machine has been on the road for 30 days. What news ? 22/10/2024 12:12
Hello William, We are on time, in the morning a driver will contact you about unloading. 22/10/2024 12:13
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Sarajevo ? 22/10/2024 12:22
Good afternoon, Benjamin! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/10/2024 12:24
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Sigisoara. 22/10/2024 12:32
Hello Ava, Delivery status checked, tomorrow until 15:30 is arriving at Sigisoara . The driver will call you beforehand. 22/10/2024 12:34
I've been calling your office since this morning, and no one's picking up the phone. 22/10/2024 12:42
Good afternoon, Benjamin! The office will be open from 9:00 GMT. We'll be in touch. 22/10/2024 12:46
Roman hello, what about the automatic filling and sealing machine for sterile ampoules ABF-4D-1, invoice #101. 22/10/2024 12:52
Good afternoon, Lucas! We are making a request to the manufacturer. Tomorrow we will send photos and video of testing to your e-mail. 22/10/2024 12:54
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- PERISTALTIC PUMPS DISPENSERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING