Video review of the model
Our service and customer service
As a result of the first four examples, the coated particles can be either compressed into tablets or placed in hard gelatin capsules. The drug substance-ion exchange resin complexes can be dispersed in viscous liquids to form liquid suspensions. It is important to recognize the fact that a sustained-release dosage form usually contains an extremely high amount of drug substance, which can cause problems if the initial dose is released quickly. This phenomenon is called “dose release” and can be eliminated if: the film coating is mechanically strong and moisture resistant; the application of the film to the material is uniform; and the drug substance is not chewed (crushed) before swallowing. Coatings providing delayed (delayed) release of the medicinal substance. When using dosage forms with delayed (delayed) release of a medicinal substance, the duration of action of the medicinal substance is increased by prolonging its release. As such a coating can be used a polymer brand Kollicoat SR 30D, the formulation of which consists of polyvinyl acetate (27%), KZO povidone (2.7%) and sodium lauryl sulfate (0.3%) as stabilizers and water (70%).
Kollicoat SR has good film-forming properties, swells easily in water, has pH-independent action and provides a strong stable delayed-release effect of the drug.
Pharmaceutical Glossary
Technical specifications
This type of coating is used in prolonged release dosage forms where an initial dose of a drug substance is released into the body and the remaining (maintenance) doses are released at a constant rate to ensure that the desired therapeutic concentration is maintained. Dosage forms with continuous, evenly prolonged release provide a sustaining effect of the drug substance. They are more effective than forms with periodic release, as they provide a constant concentration of drug in the body at the therapeutic level without pronounced extremes, do not overload the body with excessively high concentrations. Dosage forms using sustained-release coatings avoid the need for repeated administration of the drug into the body, especially for those medicine that require maintaining a constant concentration in the blood for a long period of time. In addition, sustained release is used for high-dose medicine, the rapid release of which causes undesirable side effects (e.g., ulcer formation with rapid release of potassium chloride in the GI tract). Methods of creating drug products with sustained release of the drug substance include: increasing the particle size of the drug substance; placing the drug substance in a matrix; coating the drug substance or a dosage form containing the drug substance; and forming complexes of the drug substance with materials such as ion exchange resins.
Additional information
Materials suitable for sustained-release coatings are: a mixture of waxes (e.g. beeswax) with glycerol monostearate, stearic acid, palmitic acid, glycerol monopalmitate and acetyl alcohol. They form polymers that dissolve slowly or degrade in the GI tract; shellac and zein, which do not degrade at low pH values; ethylcellulose, which forms a membrane around the dosage form that does not degrade in the GI tract. However, it is permeable to water, which dissolves the drug substance, as a result of which the latter diffuses into the GI tract; acrylic resins, the mechanism of action of which is similar to the action of ethylcellulose, i.e. there is a controlled diffusion of the drug substance through the coating; cellulose acetate (diacetate or triacetate); silicone elastomers. The development of sustained-release medicine using film coating technology can be accomplished by various methods, such as applying suitable film coatings to: dry granules (both heterogeneous and spheronized); microspheres containing the drug substance or coated with the drug substance; crystals of the drug substance; drug substance-ion exchange resin complexes; tablets (including minitabs).
Order status tracking
Can your technician come to Athens? We need technologist consultation and assistance. 05/05/2024 12:12
Elijah, We have already received your email. A technician as stipulated in the contract will contact you. Don't worry. 05/05/2024 12:15
Good day, tell me need delivery in Minneapolis to the settlement in the distance of 20 km. Can you organize this? 05/05/2024 12:22
Aiden, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 05/05/2024 12:25
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 05/05/2024 12:32
Hello Luna, The shipment has arrived at the customs terminal, the day after tomorrow is scheduled to be transferred to the transportation company. 05/05/2024 12:34
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 05/05/2024 12:42
Hello Ethan, The shipment has arrived at the customs terminal, as stipulated in the contract is scheduled to be transferred to the transportation company. 05/05/2024 12:42
In St. Gallen ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 05/05/2024 12:52
Good afternoon, Mason! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 05/05/2024 12:55
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 05/05/2024 13:02
Hello Bella, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 05/05/2024 13:02
Rotary tablet press RZK-25 I want to order with delivery to Berlin 05/05/2024 13:12
Good day, Ella We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 05/05/2024 13:13
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Austin. Thank you. 05/05/2024 13:22
Harper, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Austin is scheduled for tomorrow until 16:30. Please notify us upon receipt. 05/05/2024 13:24
RZW-29 rotary tablet press in Bruges. Regards, Nova. 05/05/2024 13:32
Nova, Delivery will be made tomorrow until 18: 30 to Bruges . Please have the movers ready. The weight of the equipment is heavy. 05/05/2024 13:33
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Pittsburgh. 05/05/2024 13:42
Good day Penelope, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Pittsburgh is included in the price. 05/05/2024 13:43
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER