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In addition, the heated pipeline protects the product from solidification. However, when producing suppositories on lipophilic bases (plastic film is usually used for their molding), which have a more liquid consistency and a low melting point (32-37 ° C), a peristaltic pump is used.
This is due to the fact that the active substances introduced into the base in the form of powder fraction can settle in the unheated pipeline or tank when the machine stops and during the slow passage of the product through the pipeline. The use of peristaltic pump allows to maintain the necessary temperature of the product, excludes its stagnation in the pipeline and settling of active substances, providing homogeneity of the suppository mass consistency. Cells are filled by inserting the filling needle into the cell opening, through which the liquid suppository mass enters. All process data is displayed on the touch screen, which is also used to set the filling volume of the cells. After the cells have been filled, the suppository belt enters the cooling unit. The product cooling process can be carried out in two or four stages, depending on the solidification time of the components that make up the suppository mass. Two-stage cooling utilizes two cooling spiral chambers installed in series, and four chambers are used for four-stage cooling. The time of two-stage cooling is 9 min and four-stage cooling is 18 min. Thanks to the spiral tracks, the suppositories are cooled on both sides by a temperature-controlled air flow until the product is fully solidified, thus obtaining the optimal shape.
The cooled contour cells are fed into the sealing unit. At first, the suppository strip is preheated, after which the top of the contour cells is sealed. The use of the preheating stage, as well as in the molding unit, ensures qualitative and reliable sealing of the package.
After sealing the cells, the code or date is applied, the cells are perforated for easy cell separation and the top edge of the tape is trimmed. The suppositories can come out of the machine in the form of a ribbon (if docking with the cartoning machine is carried out through a special docking module) or in the form of cut blisters. The number of suppositories in a blister is set from the machine control panel.
Pharmaceutical Glossary
Technical specifications
Therefore, the use in the cooling stage allows a significant reduction in the curing time of the product, as well as making the process manageable and controllable. When the suppository mass in the cooling unit is fully cured, the spool with the finished product is transferred to an automatic container sealing and ribbon cutting machine. In the machine, the ribbon is sealed and cut into sections with the specified number of cells. Sealing is carried out by pulse heating and compression. The stable temperature of the sealing tool is ensured by two high-power fans. Simultaneously with sealing the coding operation is carried out. Coding of containers (series and date) is carried out by extrusion by means of a cliché. After sealing, the edges of the tape are automatically processed. This operation allows to significantly improve the appearance of the finished product. To control the process of cutting the tape into strips of a given length, a digital programmer is used, which sets the cutting range from 1 to 10 suppositories. The machines allow the production of suppositories in contoured cell packs made of aluminum and thermoformed plastic. In contrast to medium-capacity production, in the high-capacity industrial machines, the molding of the contour cells is done directly in the machine. High-precision machine with low noise level and high productivity (up to 22 thousand suppositories per hour). The machine is controlled through a programmable logic controller (PLC). The automatic machine has an optimal mode of operation, which avoids the formation of waste in the production process. The production process of suppositories begins with the formation of contoured cell packaging made of plastic film or aluminum foil. Two rolls of plastic film (one roll – printed, from which the front part of the suppository package is molded, the second roll – unprinted) are installed on roll holders. Plastic films from both rolls simultaneously enter the pre-heating unit, where they are quickly heated to the required temperature. The required film tension is regulated by a special device. The preheated plastic films are fed to the contour cell-shaped plastic film heat-welding unit.
Additional information
In this way, the two films are joined together over the entire surface, except for the interior of the cells. Then the film enters the molding unit, where, by blowing compressed air into the unsoldered space, the contoured cell is volumetrically molded. At the same time, a small hole remains open in the upper part of each cell, through which the cell is subsequently filled with suppository mass. In case of aluminum foil packaging production, the contour cell forming unit dismantles the units designed to work with plastic film – film preheating unit, film heat-welding unit and forming unit. The aluminum foil cell forming unit is installed in their place. Due to its heavy weight, this unit is installed in the machine by means of a lifting mechanism. It should be noted that the units are common for both types of packaging. Two rolls of aluminum foil (one printed and one unprinted) are installed on the roll holders. The foil tension is adjusted by the device. The aluminum foil strips from both rolls are fed in parallel to the contour cell forming unit, where the contour of the cell is mechanically extruded on the surface of the aluminum foil strip. Thus, in contrast to plastic foil, no preheating or compressed air is required for forming cells from aluminum foil. Two unconnected ribbons with the molded halves of the contoured cells exit the forming unit. The two strips are then joined together so that the cell halves are completely overlapping and are fed into the assembly where the strips are heated and finally thermally welded together. At the same time, as in the case of the plastic film, an opening is left open at the top of each cell for the introduction of the suppository mass. In this way, the contour cell formed of plastic film or aluminum foil serves at the same time as an injection mold. The plastic or aluminum foil-formed package is fed into the filling unit in the form of a ribbon. The suppository mass, heated to a temperature of 30-80 ° C, depending on the active ingredient and base from the reservoir comes through a pipeline to the volumetric dispenser, from where the product is automatically loaded into the cells.
To maintain the required temperature and homogeneous consistency of the suppository mass, the 80-liter reservoir is equipped with a water jacket and a stirrer. In the production of glycerin-based suppositories with a viscous consistency (they are usually molded in aluminum foil), the agitator provides homogeneous mixing of the suppository mass, heated to a temperature of about 80 ° C.
Order status tracking
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 28/03/2025 03:00
Hello Oliver, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 28/03/2025 03:02
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 28/03/2025 03:10
Hello Oliver, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 28/03/2025 03:11
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 28/03/2025 03:20
Ella, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 28/03/2025 03:20
You have to pay for delivery to Mariehamn over and above the delivery amount in the contract ? 28/03/2025 03:30
Lucy, The catalog shows the price with door delivery. The unloading of the equipment, upon receipt of the shipment, will be charged to you separately. 28/03/2025 03:30
Please inform me about the status of the order Rotary tablet press RZ-10A in Cleveland ? 28/03/2025 03:40
Good afternoon, Hazel. We have contacted the carrier, delivery is scheduled tomorrow until 12:30. Please let us know when you receive it. Thank you. 28/03/2025 03:43
Tell me the NJ-120 automatic capsule machine went ? 28/03/2025 03:50
Gabriel, good afternoon. Yes, already in the interval from 10:00-12:00 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 28/03/2025 03:52
Remember me? There's a delivery in the Berlin 28/03/2025 04:00
Natalie, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be between 12:00-14:00 in Berlin . 28/03/2025 04:03
Please inform me about the status of the order Rotary tablet press RZ-10A in Detroit ? 28/03/2025 04:10
Good afternoon, Skylar. We have contacted the carrier, delivery is scheduled between 12:00-14:00. Please let us know when you receive it. Thank you. 28/03/2025 04:10
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Tucson. Please confirm the delivery time. 28/03/2025 04:20
Good afternoon Isabella, your shipment has left. Arrival time as stipulated in the contract. The driver will call you back later. Please organize prompt unloading. 28/03/2025 04:23
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 28/03/2025 04:30
Hello Gabriel, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 28/03/2025 04:31
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- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
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- BOTTLE FILLING AND CAPPING EQUIPMENT
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- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
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- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
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- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
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- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
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- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC CARTONING MACHINES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES