СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

Fluidized bed coating of fine particles at supercritical conditions is a new emerging technology for the encapsulation of thermolabile products. Supercritical fluids are unique solvents because their densities are similar to those of liquids, while viscosity and diffusion coefficient are close to these values for gases. Atomization of supercritical solutions allows the production of submicron-sized droplets and particles, as well as sputtering on and on, other particles. Since the cohesive and adhesive forces for supercritical solutions are small compared to those for organic solvents, the capillary compression force is negligible.

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Information updated: 09 / 10 / 2026
Available for
Production: 1 year на оборудование для инкапсуляции методом нанесения покрытий в псевдоожиженном слое

Model: Encapsulation

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Equipment on lease with an advance payment of 10%. Convenient payment schedule. No limit. Approval for three documents: passport, lease agreement and extract. We cooperate with leasing companies.

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Thus, the new technology of fluidized bed encapsulation under supercritical conditions allows coating thermolabile materials with particle sizes not exceeding 100 μm without particle agglomeration. The technology is increasingly being introduced into modern pharmaceutical production and requires further study to obtain effective and safe new generation drugs. Nowadays, the encapsulation process has gained new development due to the possibility of changing the pharmacological properties of drugs and the development of innovative equipment. Solid, soft and liquid active drug substances can be encapsulated in different types of shells, so this material is highlighted in a separate chapter.

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Technical specifications

This feature allows particles smaller than 100 µm to be encapsulated in the fluidized bed without forming agglomerates. At the same time supercritical fluid is used both as a solvent for the dispersed solution and as a fluidizing agent. This unit consists of three blocks: carbon dioxide supply system; extractor, in which carbon dioxide saturation with coating material takes place; high-pressure reactor. The volume of the reactor is 500 cm3; the maximum pressure in the system is 30 MPa, the maximum temperature is 373 °C. Prior to the process, the reactor is loaded with encapsulated material.

Additional information

For fluidization of the particle bed, pure carbon dioxide is fed from the bottom of the apparatus through the perforated bottom. It is experimentally confirmed that with increasing pressure in the system the minimum fluidization rate decreases. The encapsulation process starts after thermal equilibrium is established in the reactor. The carbon dioxide passes through an extractor where it is saturated with the coating agent and dispersed by a nozzle in the reactor. The dispersion results in submicron-sized droplets that settle on the surface of the particles and spread to form a thin film. After coating, the particles are allowed to dry.

Order status tracking

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Avery
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 21/10/2026 14:23

Roman Tsibulsky
Good afternoon Avery, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. tomorrow until 17:30 we will get a reply from the manufacturer on the final time frame. 21/10/2026 14:26

Noah
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Leicester. 21/10/2026 14:33

Roman Tsibulsky
Hello Noah, Delivery status checked, tomorrow until 16:30 is arriving at Leicester . The driver will call you beforehand. 21/10/2026 14:34

Sophia
Roman, our company bought VL-100 V-shaped powder mixer, but it is not enough for us, can we return it and exchange it for V-300 model? 21/10/2026 14:43

Roman Tsibulsky
Sophia, good afternoon. When we corresponded with you, I warned you that this is a model with a small load. Unfortunately we can not pick up the equipment. As an option, we will offer our customers with a discount. 21/10/2026 14:44

Ethan
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Tartu ? 21/10/2026 14:53

Roman Tsibulsky
Good afternoon, Ethan! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 21/10/2026 14:56

Ella
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Vienna ? 21/10/2026 15:03

Roman Tsibulsky
Hello Ella, your shipment is in the customs warehouse, in the morning your manager Natalia will contact you. 21/10/2026 15:04

Oliver
Automatic blister packaging machine for PVC+cardboard LW-35 with delivery to Mesa. We want to track the delivery status. 21/10/2026 15:13

Roman Tsibulsky
Oliver, hello. The shipment has already arrived. Now it is in the warehouse of the transportation company. Your manager will contact you to clarify the time of delivery to your city. 21/10/2026 15:14

Mia
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 21/10/2026 15:23

Roman Tsibulsky
Hello Mia, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 21/10/2026 15:26

Sophia
Excuse me, I have important information, please do not deliver my shipment, automatic filling and sealing machine for glass ampoules ALG-10 to Albufeira, but immediately upon arrival send it to Tbilisi. 21/10/2026 15:33

Roman Tsibulsky
Hello Sophia, we will try to resolve this issue for you. 21/10/2026 15:33

Ruby
Good day, tell me need delivery in Oklahoma City to the settlement in the distance of 20 km. Can you organize this? 21/10/2026 15:43

Roman Tsibulsky
Ruby, Good afternoon, please send us an email to info@minipress.ru with the exact name of the equipment model, city, and your coordinates. We will calculate the delivery to you. 21/10/2026 15:46

Ethan
HX-6 Plastic Tube Filling and Sealing Machine in Zurich? Price delivery terms and conditions 21/10/2026 15:53

Roman Tsibulsky
Ethan, good afternoon, we have received your request by email. In 15 minutes we will send you our quotation for this model of equipment. 21/10/2026 15:55