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The disadvantages of spray drying method include contact of thermolabile material with hot drying agent, complexity and high cost of equipment for liquid dispersion and dust collection.
Spray drying has a well-established technology, but traditional spray drying produces only microparticles. Recently, new Techniques and improved equipment are being developed to carry out the spray drying process, the aim of which is to obtain nanosized particles.
For this purpose, the following two conditions must be met: reduce the initial droplet size; use solutions with low solid phase content. It is possible to reduce the droplet size by using new atomizing devices, such as ultrasonic atomizing devices that achieve droplet sizes of 3 µm and below, or electrospray, which gives even smaller droplets. The second condition, low solids content in the solution, ensures that the initial droplet size decreases significantly as the solution is dewatered, yielding nanometer-sized particles. For example, when drying an aqueous solution with solid phase concentration not more than 7 % and initial droplet size of 1.5 microns, it is possible to obtain particles of 100 nm.
Pharmaceutical Glossary
Technical specifications
The fluid supply is pressurized. The nozzle delivers the fluid continuously or intermittently. There are many ways to atomize the liquid.
The choice of type of atomizing device and its design are determined by the properties of the atomized liquid, the need to obtain a homogeneous atomizing plume of a certain dispersion, the required productivity, the degree of complexity of construction and maintenance, as well as the cost. The main indicators of nozzles are atomization rate of liquid, macrostructure (angle and length of the jet; spatial distribution of droplets) and microstructure (size of droplets and their size distribution). The principle of operation of a pneumatic nozzle is based on the fact that compressed air breaks the solution into individual small particles, which is ejected from the nozzle of the nozzle at high velocity and dispersed torch. The position of the nozzle during atomization can be adjusted. Spray dryers operate on the principle of direct current, counter current and mixed current. Design design of spray drying plants is determined by technological requirements (type of product, its thermal lability, viscosity of the liquid, etc.), type of atomizing device, capacity for evaporated moisture and other parameters. Cyclones 6 are used to clean the exhaust air sucked from the tower by the fan. Pumps inject material and air into the pneumatic nozzle (atomization is made in counterflow of the drying agent).
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Additional information
The process scheme is as follows: the solution or suspension to be dried is fed through a pneumatic nozzle into the drying chamber. The atomization process produces a large number of polydisperse droplets. The atomized particles have a large surface area, which results in intensive heat and mass transfer with the drying agent entering the chamber through the nozzle. They quickly lose moisture and in a few seconds spherical porous granules are formed from the suspended suspension of dewatered droplets, which fall to the bottom of the chamber and fall into a container for product collection. The granules have good friability and compressibility, so tablets produced from such granulate have high strength and compressibility at low pressures. Single-section, unidirectional (direct flow of suspension droplets relative to the coolant flow) dryers are also used in the spray granulation process, which will be discussed in the next section.
The specificity of the process determines a number of characteristic advantages of the spray drying method: high quality of the dry product; high intensity of heat and mass transfer between the dispersed material and the heat transfer gas, determined by the degree of dispersibility of the material, gas temperature and hydrodynamic features of the apparatus; possibility of process control; continuity of drying.
Order status tracking
Good day, delivery time of semi-automatic drum filling machine DF-10 to Kuressaare, will the courier call us? 21/10/2024 12:51
Jayden, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 21/10/2024 12:52
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 21/10/2024 13:01
Good afternoon, Mia, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 21/10/2024 13:04
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Rotterdam ? 21/10/2024 13:11
Hello Elijah, Expect between 12:00-14:00. Once received, please let us know. 21/10/2024 13:12
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 21/10/2024 13:21
{The original shipping documents will be delivered to Nice after lunch. Please send the signed copies to us. 21/10/2024 13:24
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 21/10/2024 13:31
Elijah, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer tomorrow until 13:30. We will report back immediately. 21/10/2024 13:32
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Santorini ? 21/10/2024 13:41
Hello Mia, your shipment is in the customs warehouse, before lunch your manager Natalia will contact you. 21/10/2024 13:44
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Detroit. Please confirm the delivery time. 21/10/2024 13:51
Good afternoon Henry, your shipment has left. Arrival time after lunch. The driver will call you back later. Please organize prompt unloading. 21/10/2024 13:52
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled the day after tomorrow to open the box and test. 21/10/2024 14:01
Sebastian, good afternoon. Great news, please send a photo and video report to WhatsApp +79853643808. 21/10/2024 14:04
For shipping to Geneva do you have to pay anything extra ? 21/10/2024 14:11
Good day Ethan, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Geneva is included. 21/10/2024 14:14
Rotary tablet press RZK-25 I want to order with delivery to Berlin 21/10/2024 14:21
Good day, Penelope We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 21/10/2024 14:24
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- FLOW-PACK PACKAGING MACHINES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING