СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

Fluidized bed coating of fine particles at supercritical conditions is a new emerging technology for the encapsulation of thermolabile products. Supercritical fluids are unique solvents because their densities are similar to those of liquids, while viscosity and diffusion coefficient are close to these values for gases. Atomization of supercritical solutions allows the production of submicron-sized droplets and particles, as well as sputtering on and on, other particles. Since the cohesive and adhesive forces for supercritical solutions are small compared to those for organic solvents, the capillary compression force is negligible.

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Information updated : 28 / 12 / 2025
In stock
Manufacturer : 1 year for Encapsulation by fluidized bed coating method

Model: Encapsulation

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Thus, the new technology of fluidized bed encapsulation under supercritical conditions allows coating thermolabile materials with particle sizes not exceeding 100 μm without particle agglomeration. The technology is increasingly being introduced into modern pharmaceutical production and requires further study to obtain effective and safe new generation drugs. Nowadays, the encapsulation process has gained new development due to the possibility of changing the pharmacological properties of drugs and the development of innovative equipment. Solid, soft and liquid active drug substances can be encapsulated in different types of shells, so this material is highlighted in a separate chapter.

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Technical specifications

This feature allows particles smaller than 100 µm to be encapsulated in the fluidized bed without forming agglomerates. At the same time supercritical fluid is used both as a solvent for the dispersed solution and as a fluidizing agent. This unit consists of three blocks: carbon dioxide supply system; extractor, in which carbon dioxide saturation with coating material takes place; high-pressure reactor. The volume of the reactor is 500 cm3; the maximum pressure in the system is 30 MPa, the maximum temperature is 373 °C. Prior to the process, the reactor is loaded with encapsulated material.

Additional information

For fluidization of the particle bed, pure carbon dioxide is fed from the bottom of the apparatus through the perforated bottom. It is experimentally confirmed that with increasing pressure in the system the minimum fluidization rate decreases. The encapsulation process starts after thermal equilibrium is established in the reactor. The carbon dioxide passes through an extractor where it is saturated with the coating agent and dispersed by a nozzle in the reactor. The dispersion results in submicron-sized droplets that settle on the surface of the particles and spread to form a thin film. After coating, the particles are allowed to dry.

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Ruby
Please inform me about the status of the order Rotary tablet press RZ-10A in Riverside ? 02/01/2026 18:35

Roman Tsibulsky
Good afternoon, Ruby. We have contacted the carrier, delivery is scheduled in the interval from 10:00-12:00. Please let us know when you receive it. Thank you. 02/01/2026 18:38

Hazel
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Oklahoma City. 02/01/2026 18:45

Roman Tsibulsky
Good day Hazel, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Oklahoma City is included in the price. 02/01/2026 18:46

Alexander
Good day, delivery time of semi-automatic drum filling machine DF-10 to Lucca, will the courier call us? 02/01/2026 18:55

Roman Tsibulsky
Alexander, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 02/01/2026 18:56

Harper
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 02/01/2026 19:05

Roman Tsibulsky
Good afternoon Harper, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 02/01/2026 19:07

Maya
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 02/01/2026 19:15

Roman Tsibulsky
Hello Maya, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 02/01/2026 19:15

Aiden
When purchasing the RY-200 centrifugal type powder granulator, I asked for tests on our powder 02/01/2026 19:25

Roman Tsibulsky
Hello Aiden, Please send 2 kg of your raw material to the address given to you by Natalia. After the test, the engineer will inform you about the results. 02/01/2026 19:25

Sebastian
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 02/01/2026 19:35

Roman Tsibulsky
Sebastian, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 02/01/2026 19:36

Alexander
Tell me the NJ-120 automatic capsule machine went ? 02/01/2026 19:45

Roman Tsibulsky
Alexander, good afternoon. Yes, already in the interval from 14:00-16:00 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 02/01/2026 19:45

Elijah
To what address to send you samples of bottles and caps to send them to the factory ? Regards Elijah. 02/01/2026 19:55

Roman Tsibulsky
Good day, Elijah We received the same question on WhatsApp and replied there as well. Kindly provide the shipment number for tracking purposes. Thank you. 02/01/2026 19:55

Michael
PU-250 flow-pack packaging machine, please advise delivery status. 02/01/2026 20:05

Roman Tsibulsky
Hello Michael, your equipment is undergoing customs clearance. Your manager Natalia will contact you closer to evening 02/01/2026 20:05