СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

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СATALOGUE / PHARMACEUTICAL PRODUCTION TECHNOLOGIES / FILM-COATING OF TABLETS / Encapsulation by fluidized bed coating method

Encapsulation by fluidized bed coating method

Fluidized bed coating of fine particles at supercritical conditions is a new emerging technology for the encapsulation of thermolabile products. Supercritical fluids are unique solvents because their densities are similar to those of liquids, while viscosity and diffusion coefficient are close to these values for gases. Atomization of supercritical solutions allows the production of submicron-sized droplets and particles, as well as sputtering on and on, other particles. Since the cohesive and adhesive forces for supercritical solutions are small compared to those for organic solvents, the capillary compression force is negligible.

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Information updated : 10 / 12 / 2025
In stock
Manufacturer : 1 year for Encapsulation by fluidized bed coating method

Model: Encapsulation

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Thus, the new technology of fluidized bed encapsulation under supercritical conditions allows coating thermolabile materials with particle sizes not exceeding 100 μm without particle agglomeration. The technology is increasingly being introduced into modern pharmaceutical production and requires further study to obtain effective and safe new generation drugs. Nowadays, the encapsulation process has gained new development due to the possibility of changing the pharmacological properties of drugs and the development of innovative equipment. Solid, soft and liquid active drug substances can be encapsulated in different types of shells, so this material is highlighted in a separate chapter.

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Technical specifications

This feature allows particles smaller than 100 µm to be encapsulated in the fluidized bed without forming agglomerates. At the same time supercritical fluid is used both as a solvent for the dispersed solution and as a fluidizing agent. This unit consists of three blocks: carbon dioxide supply system; extractor, in which carbon dioxide saturation with coating material takes place; high-pressure reactor. The volume of the reactor is 500 cm3; the maximum pressure in the system is 30 MPa, the maximum temperature is 373 °C. Prior to the process, the reactor is loaded with encapsulated material.

Additional information

For fluidization of the particle bed, pure carbon dioxide is fed from the bottom of the apparatus through the perforated bottom. It is experimentally confirmed that with increasing pressure in the system the minimum fluidization rate decreases. The encapsulation process starts after thermal equilibrium is established in the reactor. The carbon dioxide passes through an extractor where it is saturated with the coating agent and dispersed by a nozzle in the reactor. The dispersion results in submicron-sized droplets that settle on the surface of the particles and spread to form a thin film. After coating, the particles are allowed to dry.

Order status tracking

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Noah
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 25/12/2025 20:04

Roman Tsibulsky
Hello Noah, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 25/12/2025 20:07

Ruby
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Corpus Christi. Please confirm the delivery time. 25/12/2025 20:14

Roman Tsibulsky
Good afternoon Ruby, your shipment has left. Arrival time closer to evening. The driver will call you back later. Please organize prompt unloading. 25/12/2025 20:16

William
In Lucca ITA-01 tablet and capsule counter, RZ-9 rotary tablet press and manual capsule filling machine. Help when we get it ? 25/12/2025 20:24

Roman Tsibulsky
Good afternoon, William! We have received from the factories photos of the equipment after packing. Natalia will forward the photos to you. Delivery time to you is 45-50 days. 25/12/2025 20:27

Mia
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Rome ? 25/12/2025 20:34

Roman Tsibulsky
Hello Mia, your shipment is in the customs warehouse, tomorrow until 12:30 your manager Natalia will contact you. 25/12/2025 20:35

Lily
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Porto, then I want to buy an automatic capsule machine model GN-28 25/12/2025 20:44

Roman Tsibulsky
Good afternoon, Lily! On the first question - the shipment will arrive in Porto closer to evening. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 25/12/2025 20:47

Ruby
Please inform me about the status of the order Rotary tablet press RZ-10A in Riverside ? 25/12/2025 20:54

Roman Tsibulsky
Good afternoon, Ruby. We have contacted the carrier, delivery is scheduled in the interval from 10:00-12:00. Please let us know when you receive it. Thank you. 25/12/2025 20:56

Hazel
Vacuum powder conveyor QV-01 quantity of 3 pieces, need discount and delivery to Oklahoma City. 25/12/2025 21:04

Roman Tsibulsky
Good day Hazel, in our catalog all prices are given including delivery to the door of the customer. If you buy 3 pieces we will make a discount of 7%. Delivery to Oklahoma City is included in the price. 25/12/2025 21:06

Alexander
Good day, delivery time of semi-automatic drum filling machine DF-10 to Lucca, will the courier call us? 25/12/2025 21:14

Roman Tsibulsky
Alexander, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 25/12/2025 21:17

Harper
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 25/12/2025 21:24

Roman Tsibulsky
Good afternoon Harper, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 25/12/2025 21:25

Maya
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 25/12/2025 21:34

Roman Tsibulsky
Hello Maya, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 25/12/2025 21:35