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Coating in drum-type systems ensures gentle processing, especially of temperature-sensitive and fragile dosage forms. For sugar draping as well as for film coating, Glatt uses a method in which a coating solution is applied to the particle from above using a two-component nozzle.
The movement and mixing of the particles in Glatt’s GMPC II is achieved by rotating the drum. The supplied process air evaporates the liquid and dries the layer. Softening and stickiness of the particle surface is prevented by selecting the appropriate process parameters. The required efficient heat exchange is achieved by the continuous perforation of the cylindrical part of the drum, thus minimizing the process time. Significant advantages of Glatjp’s sugar dredging process are gentle mixing and coating of the tablets due to the geometry of the drum and the company’s specially developed Fischer mixing paddles, which ensure absolutely uniform mixing with minimal mechanical impact on the product. With this method of dredging it is possible to coat large, non-fluidizable particles (e.g. tablets, capsules and large pellets). In general, this plant design achieves a high coating quality with throughputs ranging from 500 g to 2000 kg. DGM (Switzerland) has developed a sugar coating plant with an efficient system for spraying the coating medium and drying. The tablets in the rotating perforated drum of the plant make complex orbital movements, during which the coating medium is automatically sprayed over them according to a defined process. At the same time, hot air is fed into the drum, penetrating through the tablet layer, so that the coating medium applied to the*surface of the tablets dries quickly and evenly. In this way, a strong and smooth thin-layer coating is formed.
Pharmaceutical Glossary
Technical specifications
In addition, the ellipsoidal shaped coating machine create optimal rotational movements of the drained tablets, accelerating and improving the coating conditions.
The draining machine rotates in a clockwise direction around an axis located at an inclination (vertical and horizontal mixing) to achieve good mixing. The diameter of the coating, most often made of copper, ranges from 0.7 to 1.5 meters.
The angle of inclination of the coating to the horizontal is 30°-45°, the optimum loading is 25-30 % of the coating volume. Optimum speed of rotation of the coating machine is 20-40 rpm, the number of revolutions are selected depending on the course of the technological process. Stages of the technological process of dragging tablets are as follows: enveloping, or priming; layering, or rolling, – the most important stage, as it is here is mainly the formation of the entire shell; smoothing, or polishing; glossing – the last stage of dragging, at which the tablets are given luster, marketable appearance.
Prof. PD. Pashnev in 1975 developed a new method of coating tablets – suspension method of dragees, the dispersion medium in which is 70% sugar syrup. Polyvinylpyrrolidone (PVP) as a plasticizer, magnesium carbonate as a filler, titanium dioxide as a dye and aerosil to stabilize the suspension.
PVP is a high molecular weight compound, the molecules of which, attaching to each other, form a spatial grid in solution. Sugar molecules dissolved in water are enclosed in the grid cells.
Additional information
In the process of drying the processed tablets, the water in the individual cells is removed. The sugar remaining in the cells, crystallizing, does not have the ability to combine into agglomerates. Fine crystals with low brittleness and high plasticity are formed [2, 3]. BASF suggests the use of Collidon 25 and Collidon 30 in sugar dredging (see section 4.9). The physical characteristics of these substances, such as prevention of microcracking, adhesion of the sugar layer to the tablet core, uniform distribution of dye over the tablet coating, slower and more homogeneous crystallization of the sugar, favor the coating process and improve the quality of the coatings. Sugar coatings are particularly susceptible to cracking when applied to large batches of tablet cores that dry quickly. Since most medecine substances are hydrophobic, Collidon 25 and Collidon 30 are used as additives to prevent cracking-induced peeling of the tablet coating from the tablet core during manufacturing. Table 4.9 shows an example of a slurry composition for automatic sugar coating. The data are shown for 40 kg of 420 mg tablet nuclei in a conventional coating tank when 25 kg of the above-described slurry is atomized under the following conditions: duration of the atomization step – 5 s; interval – 10 min; hot air drying time – 10 min; total coating time -16 hr. A more modern way of sugar dredging process is offered by Glatt company, which uses for this purpose new generation drum machines.
Order status tracking
Good day, I want before lunch to get FF-02 tablet and capsule filling machine in Reykjavik? 21/11/2024 16:07
Good afternoon, Michael! We have contacted the transportation company, your shipment is arriving in Reykjavik without delay. Please wait for a call from a representative of Business Lines. 21/11/2024 16:08
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 21/11/2024 16:17
Good afternoon, Jackson! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 21/11/2024 16:17
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 21/11/2024 16:27
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Nova, this chat is only for tracking shipments. 21/11/2024 16:30
I would like to discuss the purchase of model FK-05 - capping and screw cap machine. 21/11/2024 16:37
Good day. You can call on tel. +79853643808 or to the mail specified on the site. Riley, this chat is only for tracking shipments. 21/11/2024 16:39
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 21/11/2024 16:47
Elijah, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in Dallas ? Contact Natalia, she will send the contract and invoice. 21/11/2024 16:48
Hello, I will quickly ask, what about BG-80 film coating boiler and HX-7 ultrasonic machine for sealing plastic tubes, contract No. 11 ???? 21/11/2024 16:57
Emily, good afternoon! Your positions are produced by different factories, for HX-7 the factory reported that it is 90% ready, for BG-80 we are waiting for an answer after lunch. We will report back immediately. 21/11/2024 16:59
I've been calling your office since this morning, and no one's picking up the phone. 21/11/2024 17:07
Good afternoon, Daniel! The office will be open from 9:00 GMT. We'll be in touch. 21/11/2024 17:09
Good afternoon, please confirm that between 12:00-14:00 we will receive our shipment in Riga? Contact the transportation company. 21/11/2024 17:17
Hello Aubrey ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Riga in a few days. Please expect it. 21/11/2024 17:20
Who to contact for shipment tracking ? NJ-40 automatic capsule machine in St. Louis 21/11/2024 17:27
Hello Scarlett, The shipments are carried by a transportation company. Natalia coordinates this delivery. We will contact you when the shipment arrives to you. 21/11/2024 17:28
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 21/11/2024 17:37
Hello Sofia, The shipment has arrived at the customs terminal, the day after tomorrow is scheduled to be transferred to the transportation company. 21/11/2024 17:37
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES