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Coating in drum-type systems ensures gentle processing, especially of temperature-sensitive and fragile dosage forms. For sugar draping as well as for film coating, Glatt uses a method in which a coating solution is applied to the particle from above using a two-component nozzle.
The movement and mixing of the particles in Glatt’s GMPC II is achieved by rotating the drum. The supplied process air evaporates the liquid and dries the layer. Softening and stickiness of the particle surface is prevented by selecting the appropriate process parameters. The required efficient heat exchange is achieved by the continuous perforation of the cylindrical part of the drum, thus minimizing the process time. Significant advantages of Glatjp’s sugar dredging process are gentle mixing and coating of the tablets due to the geometry of the drum and the company’s specially developed Fischer mixing paddles, which ensure absolutely uniform mixing with minimal mechanical impact on the product. With this method of dredging it is possible to coat large, non-fluidizable particles (e.g. tablets, capsules and large pellets). In general, this plant design achieves a high coating quality with throughputs ranging from 500 g to 2000 kg. DGM (Switzerland) has developed a sugar coating plant with an efficient system for spraying the coating medium and drying. The tablets in the rotating perforated drum of the plant make complex orbital movements, during which the coating medium is automatically sprayed over them according to a defined process. At the same time, hot air is fed into the drum, penetrating through the tablet layer, so that the coating medium applied to the*surface of the tablets dries quickly and evenly. In this way, a strong and smooth thin-layer coating is formed.
Pharmaceutical Glossary
Technical specifications
In addition, the ellipsoidal shaped coating machine create optimal rotational movements of the drained tablets, accelerating and improving the coating conditions.
The draining machine rotates in a clockwise direction around an axis located at an inclination (vertical and horizontal mixing) to achieve good mixing. The diameter of the coating, most often made of copper, ranges from 0.7 to 1.5 meters.
The angle of inclination of the coating to the horizontal is 30°-45°, the optimum loading is 25-30 % of the coating volume. Optimum speed of rotation of the coating machine is 20-40 rpm, the number of revolutions are selected depending on the course of the technological process. Stages of the technological process of dragging tablets are as follows: enveloping, or priming; layering, or rolling, – the most important stage, as it is here is mainly the formation of the entire shell; smoothing, or polishing; glossing – the last stage of dragging, at which the tablets are given luster, marketable appearance.
Prof. PD. Pashnev in 1975 developed a new method of coating tablets – suspension method of dragees, the dispersion medium in which is 70% sugar syrup. Polyvinylpyrrolidone (PVP) as a plasticizer, magnesium carbonate as a filler, titanium dioxide as a dye and aerosil to stabilize the suspension.
PVP is a high molecular weight compound, the molecules of which, attaching to each other, form a spatial grid in solution. Sugar molecules dissolved in water are enclosed in the grid cells.
Additional information
In the process of drying the processed tablets, the water in the individual cells is removed. The sugar remaining in the cells, crystallizing, does not have the ability to combine into agglomerates. Fine crystals with low brittleness and high plasticity are formed [2, 3]. BASF suggests the use of Collidon 25 and Collidon 30 in sugar dredging (see section 4.9). The physical characteristics of these substances, such as prevention of microcracking, adhesion of the sugar layer to the tablet core, uniform distribution of dye over the tablet coating, slower and more homogeneous crystallization of the sugar, favor the coating process and improve the quality of the coatings. Sugar coatings are particularly susceptible to cracking when applied to large batches of tablet cores that dry quickly. Since most medecine substances are hydrophobic, Collidon 25 and Collidon 30 are used as additives to prevent cracking-induced peeling of the tablet coating from the tablet core during manufacturing. Table 4.9 shows an example of a slurry composition for automatic sugar coating. The data are shown for 40 kg of 420 mg tablet nuclei in a conventional coating tank when 25 kg of the above-described slurry is atomized under the following conditions: duration of the atomization step – 5 s; interval – 10 min; hot air drying time – 10 min; total coating time -16 hr. A more modern way of sugar dredging process is offered by Glatt company, which uses for this purpose new generation drum machines.
Order status tracking
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Skradin. 24/04/2025 02:28
Hello Zoe, Delivery status checked, tomorrow until 16:30 is arriving at Skradin . The driver will call you beforehand. 24/04/2025 02:32
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Ljubljana ? 24/04/2025 02:38
Hello Benjamin, your shipment is in the customs warehouse, between 16:00-18:00 your manager Natalia will contact you. 24/04/2025 02:42
PU-420 flow-pack packaging machine along with 500 kg packaging , delivery to Las Vegas. Please confirm the delivery time. 24/04/2025 02:48
Good afternoon Mia, your shipment has left. Arrival time tomorrow until 16:30. The driver will call you back later. Please organize prompt unloading. 24/04/2025 02:50
Tell me the NJ-120 automatic capsule machine went ? 24/04/2025 02:58
Isabella, good afternoon. Yes, already tomorrow until 16:30 you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 24/04/2025 03:00
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Reykjavik, then I want to buy an automatic capsule machine model GN-28 24/04/2025 03:08
Good afternoon, Nova! On the first question - the shipment will arrive in Reykjavik the day after tomorrow. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 24/04/2025 03:11
Remember me? There's a delivery in the Monte Carlo 24/04/2025 03:18
Lila, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be before lunch in Monte Carlo . 24/04/2025 03:19
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Krakow, do you deliver to the terminal or to the actual address? 24/04/2025 03:28
Hello Scarlett, we deliver all over USA including to Krakow . The price in the catalog includes any delivery our customer asks for. 24/04/2025 03:31
Good day , Electronic conveyor belt package weight detector DK-05 when will we receive in Tbilisi ? 24/04/2025 03:38
Hello Elijah, your shipment is in the customs warehouse, tomorrow by lunchtime your manager Natalia will contact you. 24/04/2025 03:42
Granulator for wet granulation ZL-25 and Mixer V-shaped for powders VM-05 under contract No. 15 inform. 24/04/2025 03:48
Hello Michael, The shipment has arrived at the customs terminal, the day after tomorrow is scheduled to be transferred to the transportation company. 24/04/2025 03:50
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Brussels, do you deliver to the terminal or to the actual address? 24/04/2025 03:58
Hello Michael, we deliver all over USA including to Brussels . The price in the catalog includes any delivery our customer asks for. 24/04/2025 04:01
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- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
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- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
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- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
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- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
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- AUTOMATIC CARTONING MACHINES
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- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
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- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
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