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Coating in drum-type systems ensures gentle processing, especially of temperature-sensitive and fragile dosage forms. For sugar draping as well as for film coating, Glatt uses a method in which a coating solution is applied to the particle from above using a two-component nozzle.
The movement and mixing of the particles in Glatt’s GMPC II is achieved by rotating the drum. The supplied process air evaporates the liquid and dries the layer. Softening and stickiness of the particle surface is prevented by selecting the appropriate process parameters. The required efficient heat exchange is achieved by the continuous perforation of the cylindrical part of the drum, thus minimizing the process time. Significant advantages of Glatjp’s sugar dredging process are gentle mixing and coating of the tablets due to the geometry of the drum and the company’s specially developed Fischer mixing paddles, which ensure absolutely uniform mixing with minimal mechanical impact on the product. With this method of dredging it is possible to coat large, non-fluidizable particles (e.g. tablets, capsules and large pellets). In general, this plant design achieves a high coating quality with throughputs ranging from 500 g to 2000 kg. DGM (Switzerland) has developed a sugar coating plant with an efficient system for spraying the coating medium and drying. The tablets in the rotating perforated drum of the plant make complex orbital movements, during which the coating medium is automatically sprayed over them according to a defined process. At the same time, hot air is fed into the drum, penetrating through the tablet layer, so that the coating medium applied to the*surface of the tablets dries quickly and evenly. In this way, a strong and smooth thin-layer coating is formed.
Pharmaceutical Glossary
Technical specifications
In addition, the ellipsoidal shaped coating machine create optimal rotational movements of the drained tablets, accelerating and improving the coating conditions.
The draining machine rotates in a clockwise direction around an axis located at an inclination (vertical and horizontal mixing) to achieve good mixing. The diameter of the coating, most often made of copper, ranges from 0.7 to 1.5 meters.
The angle of inclination of the coating to the horizontal is 30°-45°, the optimum loading is 25-30 % of the coating volume. Optimum speed of rotation of the coating machine is 20-40 rpm, the number of revolutions are selected depending on the course of the technological process. Stages of the technological process of dragging tablets are as follows: enveloping, or priming; layering, or rolling, – the most important stage, as it is here is mainly the formation of the entire shell; smoothing, or polishing; glossing – the last stage of dragging, at which the tablets are given luster, marketable appearance.
Prof. PD. Pashnev in 1975 developed a new method of coating tablets – suspension method of dragees, the dispersion medium in which is 70% sugar syrup. Polyvinylpyrrolidone (PVP) as a plasticizer, magnesium carbonate as a filler, titanium dioxide as a dye and aerosil to stabilize the suspension.
PVP is a high molecular weight compound, the molecules of which, attaching to each other, form a spatial grid in solution. Sugar molecules dissolved in water are enclosed in the grid cells.
Additional information
In the process of drying the processed tablets, the water in the individual cells is removed. The sugar remaining in the cells, crystallizing, does not have the ability to combine into agglomerates. Fine crystals with low brittleness and high plasticity are formed [2, 3]. BASF suggests the use of Collidon 25 and Collidon 30 in sugar dredging (see section 4.9). The physical characteristics of these substances, such as prevention of microcracking, adhesion of the sugar layer to the tablet core, uniform distribution of dye over the tablet coating, slower and more homogeneous crystallization of the sugar, favor the coating process and improve the quality of the coatings. Sugar coatings are particularly susceptible to cracking when applied to large batches of tablet cores that dry quickly. Since most medecine substances are hydrophobic, Collidon 25 and Collidon 30 are used as additives to prevent cracking-induced peeling of the tablet coating from the tablet core during manufacturing. Table 4.9 shows an example of a slurry composition for automatic sugar coating. The data are shown for 40 kg of 420 mg tablet nuclei in a conventional coating tank when 25 kg of the above-described slurry is atomized under the following conditions: duration of the atomization step – 5 s; interval – 10 min; hot air drying time – 10 min; total coating time -16 hr. A more modern way of sugar dredging process is offered by Glatt company, which uses for this purpose new generation drum machines.
Order status tracking
For shipping to Madrid do you have to pay anything extra ? 22/02/2025 06:43
Good day Emily, In our catalog, all prices are inclusive of shipping to the customer's door. Delivery to Madrid is included. 22/02/2025 06:44
Rotary tablet press RZK-25 I want to order with delivery to Berlin 22/02/2025 06:53
Good day, Amelia We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 22/02/2025 06:55
Dear Roman, good afternoon, vacuum powder conveyors QV-05 in quantity of 4 pieces, already on their way to Basel ? 22/02/2025 07:03
Good afternoon, Ava! Our manager has sent a scan of the bill of lading to your email. The shipment is on its way. 22/02/2025 07:06
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 22/02/2025 07:13
Hello Chloe, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Rotterdam to 50 working ( not calendar) days. Action taken. 22/02/2025 07:13
Waiting for delivery to Cavala of a TR-02 hard gelatin capsule polishing machine. What about it? 22/02/2025 07:23
Hello Hazel, on your order we inform you that as stipulated in the contract the driver will contact you to clarify the time and place of unloading. 22/02/2025 07:26
RZW-29 rotary tablet press in Frankfurt. Regards, Joseph. 22/02/2025 07:33
Joseph, Delivery will be made in the interval from 14:00-16:00 to Frankfurt . Please have the movers ready. The weight of the equipment is heavy. 22/02/2025 07:34
Contract #12, the deadline for delivery has already passed. Take action at last. Accelerate Tsibulsky R.G. 22/02/2025 07:43
Hello Liam, we are on vacation on weekends and are not able to respond to messages. Raise the contract, delivery time of equipment to your warehouse in Istanbul to 50 working ( not calendar) days. Action taken. 22/02/2025 07:46
Horizontal granulator for organic fertilizers JU-80, the price is up to date ? Delivery time to Florence? Urgent. 22/02/2025 07:53
Hannah, Please read carefully the description of this model in our catalog. Prices are current. Timing 1-1.5 months. 22/02/2025 07:56
When is the SL-20 soft strip tablet packaging machine scheduled to be delivered to Monte Carlo ? 22/02/2025 08:03
Hello Brooklyn, Expect tomorrow until 17:30. Once received, please let us know. 22/02/2025 08:05
Hello Roman! Thank you for the service and quality of your products. We are very happy and satisfied with the purchase! 22/02/2025 08:13
Hello Leo, Apparently you have tested your vacuum lyophilic dryer LZY-01. Its quality is above average, it will work. We are waiting for your new applications. 22/02/2025 08:14
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER