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Substances containing crystallization water can be used in powders intended for subsequent dissolution. It is necessary to strictly observe the time of grinding of medicinal substances: insufficient time leads to incomplete grinding, and exceeding it may reduce the total surface area of the powder due to aggregation of ground particles. To increase the brittleness of substances, grinding with cooling is used (soaps, resins, waxy solid fats). The process is carried out with the supply of cold air after preliminary cooling in the refrigerator of the products themselves. In the case of complex powders, grinding starts with a coarse crystalline substance. Often when grinding use special techniques: for example, finer grinding of some drugs is achieved in the presence of indifferent substances (sucrose, lactose). Sometimes volatile liquids (ethanol) are added, an example is the grinding of camphor in the presence of ethanol. As the ethanol evaporates, a recrystallization phenomenon occurs and the camphor is distributed as tiny particles throughout the powder. Simple powders are obtained by thorough dry or wet grinding of dried drugs. When obtaining complex powders in factory conditions, each substance included in the mixture is milled separately and sieved through an appropriate sieve. When sieving mixtures through the openings of the sieve through the openings of the sieve pass first of all the smaller particles with a higher specific gravity, then the lighter and larger particles are sifted out. The result is a mixture of layers of different qualities, so the ingredients must be thoroughly mixed again after sieving.
Pharmaceutical Glossary
Technical specifications
Depending on this, the appropriate equipment is selected (in the first case a hammer mill is needed, in the second case a ball mill). The type of roots is also important: one type of machine is used for fibrous roots and another for non-fibrous roots. It is also necessary to take into account the moisture content of raw materials: raw materials must necessarily be dried to a residual moisture content of 6-8%. For grinding medicinal substances that form poisonous or irritating dust, use the least dusty ball mills. Grinding is carried out in separate rooms, and the mills are closed with special covers. During the grinding process, personal safety measures are applied, using special clothing for personnel. Prefabricated shredder GF-300A, used in the modern pharmaceutical industry, consists of the following components: shredder, dust collector and collector for raw materials. The principle of operation is as follows: after loading into the hopper, the raw material falls between fixed and movable toothed disks, which rotate at high speed. The raw material is transformed into powder by pulsating drilling, cutting, kneading and by pushing granules of different sizes. All working parts are made of high quality stainless steel. The grinder is manufactured in accordance with GMP standard. In the CGS jet mill from the German company NETZSCH, the grinding energy is generated by gas jets through horizontally integrated air nozzles. The gas jets create a fluidized bed in which the particles are accelerated by the gas jet. As the particles move towards the center and at the very center of the chamber, they collide with other particles moving slower, and thus comminution occurs. The air appearing in the center of the chamber “transports” the particles to the classifier, which in turn sifts out the particles that are too coarse and allows only those particles that match the settings, such as the speed of the classifier and the amount of air to pass through.
Additional information
With the CGS jet mill it is possible to achieve particle dispersities in the range of 2- /0 µm. The desired dispersity is set via a rotary classifier. Depending on the medical purpose and method of application, powders have different dispersity requirements. Crystalline powders intended to be dissolved before use by patients (e.g. magnesium sulphate, boric acid) are usually dispensed as medium, medium-fine or even coarse powders. Powder powders intended for the treatment of various injuries of the skin or mucous membranes should have a high degree of dispersibility in order to increase the total surface area of the particles of these substances and reduce their traumatic effects. For example, in calcium-containing toothpastes, calcium is in the form of fine needle-like crystals so that these crystals can fill cracks in the enamel of teeth. In the manufacture of powders, it is necessary to take into account the physicochemical properties of drugs and excipients. In the manufacture of complex powders take into account: the size and shape of crystals, solubility in ethanol, the ability to adsorb (including coloring ability), the ability to electrify (sulfur, butadione) and atomize (magnesium oxide), volatility (menthol, camphor, essential oils, etc.). Difficult to grind substances (camphor, menthol, iodine) are ground in the presence of volatile solvents – alcohol or ether, which are surfactants (10 drops of alcohol or 15 drops of ether per 1 g of substance). They facilitate the process of destruction, produce a cleaving effect and, adsorbed on the smallest particles, prevent aggregation, stabilize the powder mass. Substances with coloring properties are introduced avoiding their direct and prolonged contact with the grinding surfaces of the equipment. To avoid moistening of the powder mixture and to improve grinding, some substances (sodium and magnesium sulfates, alum) should be used dried, having previously dried them at a temperature of 40-50°C.
Order status tracking
Remember me? There's a delivery in the Venice 08/05/2024 08:21
Hannah, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be between 16:00-18:00 in Venice . 08/05/2024 08:23
Roman, can you tell me if my rotary tablet press RZJ-35 has been shipped yet? Don't send it yet, I will send to your factory in China drawings of new punches, different design. 08/05/2024 08:31
Good afternoon, Joseph! We're pausing the shipment. Send drawings to the office mail. The terms of production of new punches 20 working days. 08/05/2024 08:34
LB-205 horizontal automatic wet alcohol wipes packaging machine delivery status ...thank you 08/05/2024 08:41
Hello Savannah, it is too early to check the status of your order. In 30 days only the epat of production will be completed. 08/05/2024 08:44
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Alexandrovka. 08/05/2024 08:51
Hello Stella, Delivery status checked, tomorrow until 16:30 is arriving at Alexandrovka . The driver will call you beforehand. 08/05/2024 08:54
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 08/05/2024 09:01
Good afternoon Jayden, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 08/05/2024 09:03
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Ljubljana. 08/05/2024 09:11
Hello Olivia, Delivery status checked, tomorrow until 13:30 is arriving at Ljubljana . The driver will call you beforehand. 08/05/2024 09:15
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Liverpool, then I want to buy an automatic capsule machine model GN-28 08/05/2024 09:21
Good afternoon, Chloe! On the first question - the shipment will arrive in Liverpool tomorrow until 16:30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 08/05/2024 09:22
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 08/05/2024 09:31
Hello Samuel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Atlanta . 08/05/2024 09:33
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 08/05/2024 09:41
Hello Elizabeth, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 08/05/2024 09:45
Can your technician come to Geneva? We need technologist consultation and assistance. 08/05/2024 09:51
Penelope, We have already received your email. A technician in the interval from 14:00-16:00 will contact you. Don't worry. 08/05/2024 09:52
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS