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Substances containing crystallization water can be used in powders intended for subsequent dissolution. It is necessary to strictly observe the time of grinding of medicinal substances: insufficient time leads to incomplete grinding, and exceeding it may reduce the total surface area of the powder due to aggregation of ground particles. To increase the brittleness of substances, grinding with cooling is used (soaps, resins, waxy solid fats). The process is carried out with the supply of cold air after preliminary cooling in the refrigerator of the products themselves. In the case of complex powders, grinding starts with a coarse crystalline substance. Often when grinding use special techniques: for example, finer grinding of some drugs is achieved in the presence of indifferent substances (sucrose, lactose). Sometimes volatile liquids (ethanol) are added, an example is the grinding of camphor in the presence of ethanol. As the ethanol evaporates, a recrystallization phenomenon occurs and the camphor is distributed as tiny particles throughout the powder. Simple powders are obtained by thorough dry or wet grinding of dried drugs. When obtaining complex powders in factory conditions, each substance included in the mixture is milled separately and sieved through an appropriate sieve. When sieving mixtures through the openings of the sieve through the openings of the sieve pass first of all the smaller particles with a higher specific gravity, then the lighter and larger particles are sifted out. The result is a mixture of layers of different qualities, so the ingredients must be thoroughly mixed again after sieving.
Pharmaceutical Glossary
Technical specifications
Depending on this, the appropriate equipment is selected (in the first case a hammer mill is needed, in the second case a ball mill). The type of roots is also important: one type of machine is used for fibrous roots and another for non-fibrous roots. It is also necessary to take into account the moisture content of raw materials: raw materials must necessarily be dried to a residual moisture content of 6-8%. For grinding medicinal substances that form poisonous or irritating dust, use the least dusty ball mills. Grinding is carried out in separate rooms, and the mills are closed with special covers. During the grinding process, personal safety measures are applied, using special clothing for personnel. Prefabricated shredder GF-300A, used in the modern pharmaceutical industry, consists of the following components: shredder, dust collector and collector for raw materials. The principle of operation is as follows: after loading into the hopper, the raw material falls between fixed and movable toothed disks, which rotate at high speed. The raw material is transformed into powder by pulsating drilling, cutting, kneading and by pushing granules of different sizes. All working parts are made of high quality stainless steel. The grinder is manufactured in accordance with GMP standard. In the CGS jet mill from the German company NETZSCH, the grinding energy is generated by gas jets through horizontally integrated air nozzles. The gas jets create a fluidized bed in which the particles are accelerated by the gas jet. As the particles move towards the center and at the very center of the chamber, they collide with other particles moving slower, and thus comminution occurs. The air appearing in the center of the chamber “transports” the particles to the classifier, which in turn sifts out the particles that are too coarse and allows only those particles that match the settings, such as the speed of the classifier and the amount of air to pass through.
Additional information
With the CGS jet mill it is possible to achieve particle dispersities in the range of 2- /0 µm. The desired dispersity is set via a rotary classifier. Depending on the medical purpose and method of application, powders have different dispersity requirements. Crystalline powders intended to be dissolved before use by patients (e.g. magnesium sulphate, boric acid) are usually dispensed as medium, medium-fine or even coarse powders. Powder powders intended for the treatment of various injuries of the skin or mucous membranes should have a high degree of dispersibility in order to increase the total surface area of the particles of these substances and reduce their traumatic effects. For example, in calcium-containing toothpastes, calcium is in the form of fine needle-like crystals so that these crystals can fill cracks in the enamel of teeth. In the manufacture of powders, it is necessary to take into account the physicochemical properties of drugs and excipients. In the manufacture of complex powders take into account: the size and shape of crystals, solubility in ethanol, the ability to adsorb (including coloring ability), the ability to electrify (sulfur, butadione) and atomize (magnesium oxide), volatility (menthol, camphor, essential oils, etc.). Difficult to grind substances (camphor, menthol, iodine) are ground in the presence of volatile solvents – alcohol or ether, which are surfactants (10 drops of alcohol or 15 drops of ether per 1 g of substance). They facilitate the process of destruction, produce a cleaving effect and, adsorbed on the smallest particles, prevent aggregation, stabilize the powder mass. Substances with coloring properties are introduced avoiding their direct and prolonged contact with the grinding surfaces of the equipment. To avoid moistening of the powder mixture and to improve grinding, some substances (sodium and magnesium sulfates, alum) should be used dried, having previously dried them at a temperature of 40-50°C.
Order status tracking
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Alexandrovka. 19/05/2024 18:59
Hello Stella, Delivery status checked, tomorrow until 16:30 is arriving at Alexandrovka . The driver will call you beforehand. 19/05/2024 19:01
Have you received payment from our company ? When can we expect delivery ? Please specify realistic terms. 19/05/2024 19:09
Good afternoon Jayden, You paid a few hours ago. We told you that the delivery time is 30 to 45 days. before lunch we will get a reply from the manufacturer on the final time frame. 19/05/2024 19:12
HX-9 plastic tube filling and sealing machine bought a month ago, arrival status in Ljubljana. 19/05/2024 19:19
Hello Olivia, Delivery status checked, tomorrow until 13:30 is arriving at Ljubljana . The driver will call you beforehand. 19/05/2024 19:21
I'm waiting to get my XL-12 plastic bottle filling and capping machine to Liverpool, then I want to buy an automatic capsule machine model GN-28 19/05/2024 19:29
Good afternoon, Chloe! On the first question - the shipment will arrive in Liverpool tomorrow until 16:30. On the second question - the model GN-28 will be processed under a new contract ? Contact the office. 19/05/2024 19:32
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 19/05/2024 19:39
Hello Samuel, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Atlanta . 19/05/2024 19:39
Vacuum lyophilic freeze dryer LG-30, can we get faster than the contract ? 19/05/2024 19:49
Hello Elizabeth, Shipments go through several time stages. Manufacturing, delivery from the factory to the warehouse in Beijing or Shanghai, waiting for batch collection, customs clearance and delivery. It's hard to predict. 19/05/2024 19:52
Can your technician come to Geneva? We need technologist consultation and assistance. 19/05/2024 19:59
Penelope, We have already received your email. A technician in the interval from 14:00-16:00 will contact you. Don't worry. 19/05/2024 20:00
The BB-152 liquid filling machine arrived from you today, remember us ? Where's the paperwork? 19/05/2024 20:09
{The original shipping documents will be delivered to Venice before lunch. Please send the signed copies to us. 19/05/2024 20:12
Remember me? There's a delivery in the Nice 19/05/2024 20:19
Victoria, Hello! We remember all our customers. your blister honey filling machine model MN-82 will be after lunch in Nice . 19/05/2024 20:19
Mixer with paddle for powders CX-100 what is the exact packing size ? 19/05/2024 20:29
Avery, Hello! Packing dimensions 1200x640x1000 mm, packing weight 250 kg. Please let me know when you receive the shipment. 19/05/2024 20:31
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES