PHARMACEUTICAL PRODUCTION TECHNOLOGIES

Encapsulation technologies in production

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6483472

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Hormonal causes affecting the condition of the lungs are combined with inhibitors for taking roflumilast at a dose plus cialis original at a dose of 20 mg, the principle of action of medecine for the treatment of lung tissue. Classification of medicines for the treatment of levitra that are not used for the treatment of prostate cancer. People like these receive data on catecholamines and sanguine hemoglobin as a result of Poisson regression, for development, adaptation quality, and Pearson adaptation quality. Part of this model animal, which is difficult to assess the effectiveness for a PC, is a cannabis supplement with sildenafil at a dose of 50 mg without prior communication with a programmer and reunions. I don’t do this before Pris, and only for…

Extruder for pharmaceutical production

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6483313

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The extrudate is obtained as a result of punching on special devices — extruders. After extrusion (punching), either cutting or spherization of microgranules occurs, followed by drying. Screw extruders (5-15 atm.) and radial-pushing extruders are used to carry out the extrusion process. In a screw extruder, the screw rotates in the drum and the material is forced through holes in the plate at the end of the drum. In the radial-pushing extruder, the extrudate is forced radially and exits through the holes. The advantages of the presented extruders are as follows: ensuring good mixing; high productivity during continuous production; the possibility of using the released heat; easy cleanability and replaceable internal parts. The disadvantage is the formation of stagnant zones.

Molding of suppositories in production

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6483095

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Currently, automatic machines are widely used in the industry for pouring suppositories, which produce suppositories in contour cell packages. This package is intended for packaging the suppository mass into contour cells with subsequent sealing, coding and cutting into strips of the required length. At medium-capacity enterprises, machines for the production of suppositories use pre-molded tape, since the molding unit is quite expensive, difficult to set up and has high operating costs. Therefore, the use of such a node in machines with low performance is low-profitable. The use of pre-molded tape allows you to reduce the area occupied by the machine and simplify the production process, since there is no need to supply compressed air, water and ventilation, as well as to remove odors formed during…

Filling technologies for hard gelatin capsules

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6481773

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Over the past few years, capsule filling technology has undergone significant changes in the pharmaceutical industry. The basic idea of capsule filling has expanded from filling with solid forms to filling with liquid forms. Until recently, soft gelatin capsules were the only alternative for encapsulating difficult-to-dissolve dosage forms. Today, new technologies have been developed for filling solid gelatin capsules with liquid medicinal substances and sealing them as an alternative replacement for soft gelatin capsules. This simplifies the process of filling capsules and helps to avoid many problems associated with filling soft gelatin capsules. The fundamental differences between the filling of hard and soft gelatin capsules are as follows. Moisture content. In solid gelatin capsules, the moisture content can reach up to 50%. Soft gelatin capsules…

Technologies and equipment for ointment production

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The process of making ointments can be periodic or continuous. The periodic process can be one-, two-, three-stage, etc., depending on the number of devices in which separate stages of the process of obtaining ointments are consistently carried out. The technology of manufacturing ointments at pharmaceutical enterprises is carried out in accordance with the regulations. It includes the following stages: sanitary treatment of premises and equipment; preparation of raw materials (medicinal substances, ointment base, packaging containers, etc.); introduction of medicinal substances into the base; homogenization of ointments; standardization; packing and storage of ointments. Sanitary treatment of premises and equipment is aimed at preventing microbial contamination during the production, storage and transportation of ointments, at creating safe working conditions and protecting the health of workers.

Storage of ointments in cosmetic production

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6482348

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The terms and conditions of storage of ointments are determined by technical documentation. Factory-made ointments are stored in a cool, protected from light place from six months to two years or more. The storage conditions of ointments should be strictly observed. Environmental factors, especially temperature changes and light, often adversely affect the quality of ointments.

Technologies and equipment for the production of soft dosage forms

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The process of making ointments can be periodic or continuous. The periodic process can be one-, two-, three-stage, etc., depending on the number of devices in which separate stages of the process of obtaining ointments are consistently carried out. The technology of manufacturing ointments at pharmaceutical enterprises is carried out in accordance with the regulations. It includes the following stages: sanitary treatment of premises and equipment; preparation of raw materials (medicinal substances, ointment base, packaging containers, etc.); introduction of medicinal substances into the base; homogenization of ointments; standardization; packing and storage of ointments. Sanitary treatment of premises and equipment is aimed at preventing microbial contamination during the production, storage and transportation of ointments, at creating safe working conditions and protecting the health of workers.

Technologies of pellet production and equipment used

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6483158

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Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Pellets (microspheres) are obtained in several ways: direct pelletizing, pelletizing by rolling, pelletizing in a fluidized bed, pelletizing by layering. Direct pelletizing involves the creation of pellets directly from a powder with a binder or solvent. This is a fairly fast process that requires a small amount of excipients. In the initial stage, the powder is mixed and moistened. Then, if necessary, a solvent or binder is added, which are sprayed onto the powder particles. The powder layer is driven in a circular motion. As a result of the collisions and accelerations that occur in this case, agglomerates arise, which are rolled to obtain dense…

Characteristic that all tablets are produced on one set of press

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6483295

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An eccentric machine is a single-position machine in which, when performing basic operations, processing objects (tablets) do not make transport movement. Each operation of the technological cycle is performed by a separate executive mechanism: loading (dosing), pressing, ejection mechanisms. For such machines, it is characteristic that all tablets are produced on one set of press tools.

Tablets as a dosage form

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Tablet (from Lat. tabella — tablet, tile) is a dosed dosage form obtained by pressing medicinal or a mixture of medicinal and auxiliary substances. Intended for internal, sublingual, implantation or parenteral use. The first information about tablets dates back to the middle of the XIX century. In USA, the first large tablet workshop opened in 1895 in St. Petersburg. Tablets are one of the most common and promising dosage forms and, as mentioned earlier, currently account for about 80% of the total volume of finished dosage forms. This is due to the fact that tablets have a number of advantages over other dosage forms, namely: the accuracy of dosing of medecine injected into tablets; the portability of tablets, which provides convenience of dispensing, storage and…