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In addition to gelatin capsules, polymeric capsules are used in the pharmaceutical industry. Let us explain their use by one example. Scientists at the Faculty of Chemistry of Lomonosov USA State University proposed to give insulin in tablets instead of injections to diabetics. They developed a multilayer polymer capsule that protects insulin from the destructive action of gastric juice. This invention has largely made life easier for diabetics, as they have to take regular injections (up to several times a day) to control their blood sugar levels. But the fact that insulin breaks down quickly in the acidic environment of the stomach makes it very difficult, if not impossible, to create insulin in tablets. Scientists have found a way to protect insulin from gastric juice while preserving its properties by creating a multi-layered polymer capsule. In an acidic environment it is stable and remains intact, while in a neutral environment it gradually releases insulin. To create such a capsule, the scientists used two polymers: positively charged protamine and negatively charged dextran sulfate. They were successively layered on top of each other on the principle of “plus to minus”, forming a multilayer shell around the insulin filling, which makes up to 85% of the entire microparticle. The insulin in the protective capsule is stable at pH between 1.7 and 5, and is released at higher pH values. This pH dependence of protective polymer capsules makes it possible to create insulin in tablets. In the stomach, where the environment is very acidic, the capsules will protect the insulin molecule and prevent it from breaking down. After passing through the stomach and reaching the small intestine and ileum, where the pH reaches 6-8 units, the capsules will begin to release insulin intensively. From the small intestine, insulin can enter the bloodstream. It turns out that the capsule itself will determine where to keep the insulin closed and where to release it. The substances used to create the capsules are natural biodegradable polymers. They are easily broken down by enzymes and excreted from the body without causing any harm to health. All the above-mentioned diversity in approaches to the creation of capsule compositions and technology of their production must be taken into account in the development of drugs in the form of capsules. Each drug substance, possessing inherently specific physicochemical, pharmacological and pharmacokinetic properties, requires an individual approach to the creation of a dosage form. This is taken into account by scientists in the development of encapsulated pharmaceuticals.
Pharmaceutical Glossary
Technical specifications
Currently, the capsule manufacturing process is continuously monitored by sampling at each stage of production. Parameters such as dimensions, visual defects, moisture content, color and microbiological purity are continuously monitored during production. If a defect is detected, the entire batch is withdrawn regardless of the stage of readiness. The capsules are subjected to all types of analysis once again at the end of the production process, after which the final result of the quality check is issued. In recent years, capsules with specified release properties of the active ingredient have become more and more widespread – these are intestine-soluble capsules (with release of the drug substance in the intestine) and so-called retard capsules (with prolonged release). Creation of enteric soluble dosage forms is carried out in order to prevent the release of the active substance in the stomach (to ensure the stability of the drug substance, to prevent its concentration decrease under the action of gastric juice, to reduce possible side effects, to prevent possible undesirable neutralization of gastric juice, etc.). Intestine-soluble capsules are produced by two methods: by applying film coatings to the finished and filled capsule. Special compositions are used to coat capsules, the main components of which are most often shellac, cellulose derivatives (e.g., simple or esters), polymethacrylates, copolymers (styrene and maleic acid, vinyl acetate, caproic acid, etc.), natural waxes, sodium alginate and others; intestine-soluble properties are imparted to the filler itself – intestine-soluble film coatings are applied directly to granules, pellets or microcapsules. Along with the previous method, this method is by far the most demanded in the production of enteric soluble preparations in capsule form. To give prolonged properties to capsulated drugs use technological methods of introducing special ingredients in the composition of the filler for capsules. Usually used combinations of substances that prevent the rapid release of the active components of the dosage form, among which the most used are indifferent to the human body acrylic polymers (Eudragit several brands), cellulose derivatives (microcrystalline cellulose, oxypropyl methyl cellulose, methyl cellulose, etc.), some other substances.
Additional information
Currently, the dosage form in the form of gelatin capsules has become very popular with pharmaceutical manufacturers, consumers and physicians due to a number of advantages and positive characteristics. These include, among others:
High dosing accuracy of the drug substances placed in them. Modern equipment ensures high accuracy of filling capsules with filler (with a tolerance not exceeding ±3%) and minimal losses. High bioavailability. Studies have shown that capsules often disintegrate faster in the human body than tablets or dragees, and their liquid or unabsorbed solid contents are more quickly and easily absorbed. The pharmacological action of the drug substance is manifested in 4-5 min. High stability. Drug substances in capsules are protected from various unfavorable environmental factors – the effects of light, air, moisture, mechanical influences – due to the shell, which provides a sufficiently high tightness and isolation of components. Therefore, in the manufacture of capsules it is possible to avoid the need to use antioxidants or stabilizers or reduce their amount.
Corrective ability – unpleasant taste and odor of medicinal substances is eliminated, which is especially important in pediatrics. High aesthetics – achieved through the use of various dyes in obtaining capsule shells. Today, leading pharmaceutical companies use up to 1,000 different colors and shades for coloring capsule shells.
Possibility to set specific properties of drug substances – creation of intestine-soluble capsules, as well as urethard capsules (with prolonged drug release), which can be achieved by various technological methods.
Order status tracking
Tell me the NJ-120 automatic capsule machine went ? 08/05/2024 17:59
Amelia, good afternoon. Yes, already the day after tomorrow you will receive it. Taking into account the heavy weight of the equipment, we ask you to take care of unloading by forklift in advance. The transportation company does not provide unloading. Only delivery to the address. 08/05/2024 18:01
How to contact you for shipment tracking ? Industrial vibrating screen VS-04. 08/05/2024 18:09
Good afternoon, Emma, My WhastApp is +79853643808, Manager Natalia +79153808881 during business hours and except weekends. 08/05/2024 18:12
PU-250 flow-pack packaging machine, please advise delivery status. 08/05/2024 18:19
Hello Oliver, your equipment is undergoing customs clearance. Your manager Natalia will contact you tomorrow until 18: 30 08/05/2024 18:20
Good afternoon, we have contracted you to deliver a GK-40 dry powder granulator to Monte Carlo, do you deliver to the terminal or to the actual address? 08/05/2024 18:29
Hello James, we ship all over Europe and the US including to Monte Carlo . The price in the catalog includes any delivery our customer asks for. 08/05/2024 18:29
Good afternoon, we received the PR-15 powder dispenser in plastic vials, scheduled after lunch to open the box and test. 08/05/2024 18:39
Emily, Good afternoon. Great news, please WhatsApp +79853643808 to send photo and video report. 08/05/2024 18:41
PU-250 flow-pack packaging machine, please advise delivery status. 08/05/2024 18:49
Hello William, your equipment is undergoing customs clearance. Your manager Natalia will contact you as agreed 08/05/2024 18:50
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 08/05/2024 18:59
Good day, Harper! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 08/05/2024 19:02
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 08/05/2024 19:09
Good day, Avery! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 08/05/2024 19:10
We have sent to info@minipress.ru photos of the damaged box with induction welding membrane machine FG-08. Please call back. 08/05/2024 19:19
Good day, Evelyn! Damage to the packaging is unfortunately a common practice in transportation. Please carefully unpack the shipment and send us a series of photos. We will take a look and take action. 08/05/2024 19:19
We received our order (BG-150 film coating boiler) in the box there was no spraying nozzle !!! 08/05/2024 19:29
Hello Alexander, we checked with the factory. Your nozzle was not received in time for the shipment of the main machine. We will now deliver it to you by DHL express mail. 08/05/2024 19:31
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COATING TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- BOTTLE FILLING AND CAPPING EQUIPMENT
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- PERISTALTIC PUMPS DISPENSERS
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION