Currently, the capsule manufacturing process is continuously monitored by sampling at each stage of production. Parameters such as dimensions, visual defects, moisture content, color and microbiological purity are continuously monitored during production. If a defect is detected, the entire batch is withdrawn regardless of the stage of readiness. The capsules are subjected to all types of analysis once again at the end of the production process, after which the final result of the quality check is issued. In recent years, capsules with specified release properties of the active ingredient have become more and more widespread – these are intestine-soluble capsules (with release of the drug substance in the intestine) and so-called retard capsules (with prolonged release). Creation of enteric soluble dosage forms is carried out in order to prevent the release of the active substance in the stomach (to ensure the stability of the drug substance, to prevent its concentration decrease under the action of gastric juice, to reduce possible side effects, to prevent possible undesirable neutralization of gastric juice, etc.). Intestine-soluble capsules are produced by two methods: by applying film coatings to the finished and filled capsule. Special compositions are used to coat capsules, the main components of which are most often shellac, cellulose derivatives (e.g., simple or esters), polymethacrylates, copolymers (styrene and maleic acid, vinyl acetate, caproic acid, etc.), natural waxes, sodium alginate and others; intestine-soluble properties are imparted to the filler itself – intestine-soluble film coatings are applied directly to granules, pellets or microcapsules. Along with the previous method, this method is by far the most demanded in the production of enteric soluble preparations in capsule form. To give prolonged properties to capsulated drugs use technological methods of introducing special ingredients in the composition of the filler for capsules. Usually used combinations of substances that prevent the rapid release of the active components of the dosage form, among which the most used are indifferent to the human body acrylic polymers (Eudragit several brands), cellulose derivatives (microcrystalline cellulose, oxypropyl methyl cellulose, methyl cellulose, etc.), some other substances.

Currently, the dosage form in the form of gelatin capsules has become very popular with pharmaceutical manufacturers, consumers and physicians due to a number of advantages and positive characteristics. These include, among others:
High dosing accuracy of the drug substances placed in them. Modern equipment ensures high accuracy of filling capsules with filler (with a tolerance not exceeding ±3%) and minimal losses. High bioavailability. Studies have shown that capsules often disintegrate faster in the human body than tablets or dragees, and their liquid or unabsorbed solid contents are more quickly and easily absorbed. The pharmacological action of the drug substance is manifested in 4-5 min. High stability. Drug substances in capsules are protected from various unfavorable environmental factors – the effects of light, air, moisture, mechanical influences – due to the shell, which provides a sufficiently high tightness and isolation of components. Therefore, in the manufacture of capsules it is possible to avoid the need to use antioxidants or stabilizers or reduce their amount.
Corrective ability – unpleasant taste and odor of medicinal substances is eliminated, which is especially important in pediatrics. High aesthetics – achieved through the use of various dyes in obtaining capsule shells. Today, leading pharmaceutical companies use up to 1,000 different colors and shades for coloring capsule shells.
Possibility to set specific properties of drug substances – creation of intestine-soluble capsules, as well as urethard capsules (with prolonged drug release), which can be achieved by various technological methods.