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Delivery of the active substance to any part of the GI tract is achieved by using as a coating exactly those types of Eudragit polymers that dissolve at certain acidity (pH) values of the environment peculiar to this or that part of the GI tract. It is also possible to use combinations of separate types of polymers when it is necessary to deliver drugs to a strictly defined part of the GI tract. The described feature of Eudragit films is crucial for more effective treatment of a number of diseases, including ulcerative colitis, Crohn’s disease and even some cancers. The intestinal soluble coating (water-based) is Kollicoat MAE 30DP (methacrylic acid + ethyl acrylate 1+1) polymer as a 30% water-soluble dispersion and Kollicoat MAE 100P polymer as a 100% water-dispersible powder. Kollicoat is the patented name for all BASF coatings. Kollicoat MAE 1 OOP is a powder consisting mainly of methacrylic acid-ethyl acrylate copolymer (1:1). It has an average molecular weight of approximately 250,000 kDa. It is prepared from Kollicoat MAE*30DP by neutralizing up to about 6 mol% of the copolymer with sodium hydroxide. Additionally, this powder includes two stabilizers to prevent sedimentation and degradation of the copolymer. These polymers form non-hygroscopic films, which require a plasticizer to give the product the necessary elasticity, as the film is quite brittle. Kollicoat MAE films are completely insoluble in acidic media (e.g. 0.1 M HC1 or gastric juice). However, at pH values >5.5 they dissolve at an increasing rate. Therefore, these films are optimally suited for enteric-coated tablets that dissolve after passing through the stomach.
Pharmaceutical Glossary
Technical specifications
Intestine-soluble coatings are used for dosage forms that, when administered, are expected to delay the release of drugs, may be destroyed in the stomach (e.g., pancreatin, erythromycin), may cause nausea or bleeding, or may cause irritation of the gastric mucosa (e.g., aspirin, steroids). Such coatings can be used to re-release drugs in different parts of the GI tract. The action of intestine-soluble coating is due to the difference in properties of gastric and intestinal media due to different acidity and enzyme composition. Although some time ago there were attempts to create coatings that degrade under the action of intestinal enzymes, these developments were not popular, because enzymatic degradation of the film is a rather long process. Thus, most of the widely used intestine-soluble coatings are weak acids that do not dissociate at low pH values, but are easily ionized when the pH of the medium is increased to 5. The most effective enteric soluble polymers are polyacids. Enzyme-degradable coatings are currently used as protective coatings for delivery of polypeptide drug substances into the colon. One of the first synthetic polymers used for intestine-degradable coatings is phthalate cellulose acetate (PCA). However, pH>6 is required for dissolution of the coating, which significantly delays drug release. This polymer is relatively permeable to moisture and gastric juice compared to most enteric soluble polymers. In addition, it is highly susceptible to hydrolytic degradation, in which phthalic acid separates from acetic acid, leading to changes in the properties of the polymer and hence the action of the enteric coating.
Additional information
Other useful polymers used in enteric coating formulations include: Polyvinyl acetate phthalate (PVAP), which is less permeable to moisture and gastric juice, more resistant to hydrolysis, and able to ionize at low pH values; hydroxypropyl methylcellulose phthalate (HPMCP), which has properties similar to those of PVAP; acrylic polymers such as methacrylic acid or methacrylic acid ester copolymer (some of which have a high dissociation constant); cellulose acetate trimellitate (ATC), which has properties similar to those of AFC; carboxymethyl ethyl cellulose (CMEC); hydroxypropyl methylcellulose acetate succinate (HPMCS).
In recent years, acrylic copolymers have been considered most suitable for the development of enteric coatings. A new type of film coatings has emerged, based on poly-methyl methacrylates (PMMA), polymers derived from acrylic acid, called Eudragit, which have the following properties: Excellent moisture-, heat- and light-protective properties, hence increasing the shelf life of drugs (far exceeding the corresponding properties of cellulose); complete neutralization of unpleasant taste and odor, which are often possessed by the active ingredients in the tablet; ease of swallowing large-sized tablets due to the sliding properties of the films; uniformly colored tablets of any shade when combined with pigments; delivery of the active ingredient to any part of the GI tract; use of Eudragit as a matrix for dosage forms with retarded
Order status tracking
The MZ-10 expiration date and date handheld printer has still not been delivered. The driver did not answer and dropped calls yesterday. 24/08/2024 13:47
Hello Daniel, Transportation has advised that In the afternoon driver will definitely deliver the box to your address. We apologize. 24/08/2024 13:50
YR-90 dry and wet powder granulator YR-90 month has already passed. Hurry up the factory. 24/08/2024 13:57
Jackson, good afternoon. The factory has shipped your equipment to our representative, now is forming a consolidated shipment for shipment to customs. We will keep you informed. 24/08/2024 13:58
Good afternoon, please confirm that In the afternoon we will receive our shipment in Dubrovnik? Contact the transportation company. 24/08/2024 14:07
Hello Alexander ! Representatives of the transportation company on the delivery status of your shipment said that it will be in Dubrovnik in a few days. Please expect it. 24/08/2024 14:08
Please advise the delivery status of the order. Desktop ampoule sealing machine RF-01 delivery to Wichita. Thank you. 24/08/2024 14:17
Isabella, Checked delivery status , your shipment is in transit warehouse in Shanghai. Delivery to Wichita is scheduled for the day after tomorrow. Please notify us upon receipt. 24/08/2024 14:19
Dear Roman. Deadline (time) I am waiting for your quotation for a machine for removing tablets and capsules from blister packs MB-10 with delivery. 24/08/2024 14:27
Hello Grayson, By the specified time we will send the offer to your e-mail. Now we are waiting for an answer from the transportation company on the delivery time to Oklahoma City . 24/08/2024 14:31
I've been calling your office since this morning, and no one's picking up the phone. 24/08/2024 14:37
Good afternoon, Benjamin! The office will be open from 9:00 GMT. We'll be in touch. 24/08/2024 14:40
I've been calling your office since this morning, and no one's picking up the phone. 24/08/2024 14:47
Good afternoon, Dylan! The office will be open from 9:00 GMT. We'll be in touch. 24/08/2024 14:50
Rotary tablet press RZK-25 I want to order with delivery to Berlin 24/08/2024 14:57
Good day, Amelia We have checked the information on your request, unfortunately the factory has stopped production of this model of equipment. Send to the mail a description of your task, or contact your manager. We will help in any case with the choice. 24/08/2024 14:58
Good day, delivery time of semi-automatic drum filling machine DF-10 to Tartu, will the courier call us? 24/08/2024 15:07
Michael, good afternoon. Natalia will contact you, the shipment has passed customs clearance at the border. 24/08/2024 15:08
Dear Roman, how are you doing? Our company bought more than a year ago a filling and capping machine for penicillin vials, model XL-10. We got financing this year and want the same machine. Will you give us a discount? 24/08/2024 15:17
Lily, thank you. We're doing great. Of course we will give a discount to the regular customer. Delivery of equipment also in San Francisco ? Contact Natalia, she will send the contract and invoice. 24/08/2024 15:21
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- PERISTALTIC PUMPS DISPENSERS
- EQUIPMENT FOR FILLING HARD GELATIN CAPSULES WITH POWDER
- BOTTLE FILLING AND CAPPING EQUIPMENT
- EQUIPMENT FOR FILLING CREAMS AND SEALING PLASTIC TUBES
- EQUIPMENT FOR POLISHING AND DEDUSTING TABLETS AND CAPSULES
- AUTOMATIC EQUIPMENT FOR REMOVING TABLETS AND CAPSULES FROM BLISTERS
- EQUIPMENT FOR PACKAGING TABLETS AND CAPSULES IN PLASTIC BOTTLES
- EQUIPMENT FOR THE PRODUCTION OF TABLETS
- EQUIPMENT FOR COATING TABLETS
- EQUIPMENT FOR FILLING AND SEALING GLASS AMPOULES
- MACHINES FOR FORMING AND FILLING PLASTIC AMPOULES
- EQUIPMENT FOR WASHING AND STERILIZING BOTTLES
- EQUIPMENT FOR COUNTING AND PACKAGING TABLETS AND CAPSULES IN BOTTLES
- SPRAY DRYING EQUIPMENT FOR SUSPENSIONS
- EQUIPMENT FOR PRINTING LOGO ON TABLETS AND CAPSULES
- HIGH-PRECISION DOSING MACHINES POWDER FILLING MACHINES
- MACHINES FOR THE PRODUCTION OF SUPPOSITORIES
- EQUIPMENT FOR PACKING POWDERS INTO VIALS
- POWDER GRANULATION EQUIPMENT
- AUTOMATIC PHARMACEUTICAL CENTRIFUGES
- EQUIPMENT FOR VACUUM TRANSPORTATION OF POWDERS
- EQUIPMENT FOR AUTOMATIC BOTTLE FEEDING FOR FILLING LINES
- EQUIPMENT FOR SCREW FEEDING OF POWDERS
- EQUIPMENT FOR HOMOGENIZING CREAMS AND OINTMENTS
- EQUIPMENT FOR EFFICIENT MIXING OF POWDERS
- AUTOMATIC EQUIPMENT FOR SELF-ADHESIVE LABELS ON PACKAGING
- EQUIPMENT FOR WRAPPING CARDBOARD BOXES WITH CELLOPHANE
- EQUIPMENT FOR PACKAGING TABLETS IN STRIPS AND TUBES
- EQUIPMENT FOR FILLING AND PACKAGING HERBAL TINCTURES
- EQUIPMENT FOR PACKING TEA INTO TEA BAGS WITH THREAD AND LABEL
- EQUIPMENT FOR FILLING LIQUIDS IN PLASTIC AND METAL BARRELS
- EQUIPMENT FOR PACKAGING FOOD PRODUCTS IN DOY-PACK PACKAGES
- EQUIPMENT FOR INDUCTION SEALING OF ALU FOIL BOTTLES
- EQUIPMENT FOR PACKAGING PRODUCTS IN A FLOW PACK
- EQUIPMENT FOR METAL DETECTOR IN GELATIN CAPSULES AND TABLETS
- EQUIPMENT FOR PACKAGING BULK MATERIALS IN PLASTIC BAGS
- FLOW-PACK PACKAGING MACHINES
- EQUIPMENT FOR THE MANUFACTURE AND PACKAGING OF WET ALCOHOL WIPES
- AUTOMATIC CARTONING MACHINES
- EQUIPMENT FOR APPLYING THE EXPIRATION DATE AND BATCH NUMBER TO PRODUCTS
- EQUIPMENT FOR WEIGHT CONTROL AND SORTING OF CARDBOARD BOXES WITH MEDICINE
- AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- EQUIPMENT FOR VACUUM PACKAGING IN PLASTIC BAGS
- DESKTOP EQUIPMENT FOR LIQUID DOSING
- DESKTOP EQUIPMENT FOR HIGH-SPEED EMULSION PRODUCTION
- EQUIPMENT FOR POWDERING PHARMA RAW MATERIALS
- MACHINES PRINTING EXPIRATION DATE AND LOT NUMBER
- SEMI-AUTOMATIC EQUIPMENT FOR BLISTER PACKAGING
- SEMI-AUTOMATIC EQUIPMENT FOR FILLING GELATIN CAPSULES
- PERISTALTIC PUMPS DISPENSERS
- DESKTOP EQUIPMENT FOR MIXING POWDERS
- EQUIPMENT FOR VIBRATING SIEVING OF POWDERS
- EQUIPMENT FOR THE PRODUCTION OF FISHING BOILIES
- EQUIPMENT FOR LABORATORY TESTING OF MEDICINES
- MANUAL EQUIPMENT FOR FILLING GELATIN CAPSULES WITH POWDER
- EQUIPMENT FOR MIXING LIQUIDS WITH MICROWAVE HEATING
- EQUIPMENT FOR AUTOMATIC DOSING OF CREAMS AND OINTMENTS